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arthyper

Артериальная гипертензия

"Arterial’naya Gipertenziya" ("Arterial Hypertension")

1607-419X2411-8524

Antihypertensive League

10.18705/1607-419X-2013-19-4-

arthyper-100

Research Article

ПРИГЛАШЕНИЕ К ДИСКУССИИ

DISCUSSION

СОВРЕМЕННЫЙ ВЗГЛЯД НА РОЛЬ АСЕПТИЧЕСКОГО ВОСПАЛЕНИЯ ЖИРОВОЙ ТКАНИ В ГЕНЕЗЕ ОЖИРЕНИЯ И МЕТАБОЛИЧЕСКОГО СИНДРОМА

UP-TO-DATE VIEW AT THE ROLE OF ASEPTIC INFLAMMATION OF ADIPOSE TISSUE IN THE GENESIS OF OBESITY AND METABOLIC SYNDROME

Крюков

Н. Н.

Kryukov

N. N.

Доктор медицинских наук, профессор, заведующий кафедрой внутренних болезней, проректор по научной и инновационной работе СамГМУ

kisel@live.com

Гинзбург

М. М.

Ginzburg

M. M.

Доктор медицинских наук, ассистент кафедры внутренних болезней СамГМУ

kisel@live.com

Киселева

Е. В.

Kiseleva

E. V,.

Старший лаборант кафедры внутренних болезней СамГМУ.

Контактная информация: ГБОУ ВПО «Самарский государственный медицинский университет» Министерства здравоохранения России, кафедра внутренних болезней, ул. Аксакова, д. 13, Самара, Россия, 443030. E-mail: kisel@live.com (Киселева Елена Владимировна).

Corresponding author: Samara State Medical University, 13 Aksakov st., Samara, Russia, 443030. E-mail: kisel@live.com (Elena V. Kiseleva, Senior Assistant at the Department of Internal Medicine at Samara State Medical University).

kisel@live.com

Самарский государственный медицинский университет, СамараРоссияSamara State Medical University, SamaraRussian Federation

2013

28082013

194305310

2013

Крюков Н.Н., Гинзбург М.М., Киселева Е.В.

Kryukov N.N., Ginzburg M.M., Kiseleva E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://htn.almazovcentre.ru/jour/article/view/100

За два последних десятилетия коренным образом изменились взгляды на роль жировой ткани в метаболическом и энергетическом обмене. Поступают все новые и новые свидетельства о продукции жировой тканью целого класса биологически активных веществ, так называемых адипоцитокинов, общими свойствами которых являются участие в регуляции обменных процессов на местном или системном уровне, повышение или снижение чувствительности тканей к инсулину, а также провоспалительное или противовоспалительное действие. Анализируя взаимосвязь и взаимовлияние абдоминального ожирения, асептического воспаления жировой ткани и инсулинорезистентности, следует подчеркнуть, что данные процессы действуют по принципу взаимоусиления, формируя порочный круг. Более глубокому пониманию участия адипокинов и цитокинов в развитии ожирения и метаболического синдрома способствовало бы выяснение их биологической роли

Over the past two decades the views at the role of adipose tissue in the metabolic and energy metabolism have radically changed. There have appeared more and more evidence on the production of biologically active substances by adipose tissue, the so-called adipocytokines that are involved in the regulation of metabolic processes at the local or systemic level, of the tissue sensitivity to insulin, as well as pro-inlammatory or anti-inlammatory effect. By analysing the relationship and interaction of abdominal obesity, aseptic inlammation of adipose tissue and insulin resistance, it should be emphasized that these processes operate on the principle of mutual reinforcement, forming a vicious circle. Further understanding of adipokines and cytokines participation in the development of obesity and metabolic syndrome may contribute to a deeper insight into their biological role.

ожирениеметаболический синдромасептическое воспалениеадипонектин

obesitymetabolic syndromeaseptic inflammationadiponectin

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The authors declare that there are no conflicts of interest present.