arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2005-11-1-34-38arthyper-1004Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние антигипертензивной терапии на функциональное состояние системы гипофиз-гонады у пациентов с артериальной гипертензиейImpact of antihypertensive therapy on the functional state of the pituitary-gonadal system in patients with arterial hypertensionИвановН. В.IvanovN. V.noemail@neicon.ruСанкт-Петербургская медицинская академия последипломного образованияRussian Federation2005280220051113438Copyright © Иванов Н.В., 20052005Иванов Н.В.Ivanov N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1004

Целью работы было изучение влияния гипотензивной терапии блокаторами медленных кальциевых каналов, ингибиторами ангиотензинпревращающего фермента (ИАПФ) и блокаторами ß-адренергических рецепторов на метаболизм и содержание в крови основных андрогенов надпочечников и гонад, а также уровень инсулинорезистентности у мужчин с артериальной гипертензией (АГ) Обследован 91 пациент с АГ и 15 здоровых паритетных по возрасту мужчин, составивших контрольную группу У мужчин с АГ, получавших терапию блокаторами медленных кальциевых каналов или ИАПФ, выявлено снижение уровня инсулина, повышение уровней дегидроэпиандростерона-сульфата и свободного тестостерона на 30-й день лечения У мужчин с АГ, получавших терапию блокаторами ß-адренергических рецепторов, выявле но повышение уровня инсулина и снижение уровней основных надпочечниковых и тестикулярных андрогенов в сравнении с показателями до начала лечения Уровни гонадотропных гормонов, эстрадиола и кортизола не изменялись под влиянием терапии и не отличались в сравниваемых группах Наличие наследственной отягощенности по АГ оказывает модулирующее влияние на гормональный ответ у мужчин с АГ под влиянием гипотензивной терапии

The aim of the study was to evaluate the impact of antihypertensive therapy with slow calcium-channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and ß-adrenergic receptor blockers on the metabolism and blood levels of major adrenal androgens and gonads, as well as the insulin resistance in males with arterial hypertension (AH) Ninety-one patients with AH and 15 age-matched healthy male controls were examined The hypertensive males treated with slow calcium-channel blockers or ACE inhibitors were found to have a lower level of insulin and higher levels of dehydroepiandrosterone sulfate and free testosterone on the 30th day of treatment Those on blockers were observed to have a higher level of insulin and lower levels of major adrenal and testicular androgens as compared with their baseline levels Therapy did not alter the levels of gonadotropic hormones, estradiol, and cortisol and they did not differ in the compared groups The family history of AH has a modulating effect on a hormonal response in males with AH treated with antihypertensive agents

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The authors declare that there are no conflicts of interest present.