arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2006-12-1-56-58arthyper-1046Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСравнительная эффективность Нолипрела форте и Ко-ренитека у больных артериальной гипертензией высокого рискаComparative efficacy Noliprel forte and Ko-renitec at high risk arterial hypertension patientsНедогодаС. В.NedogodaS.noemail@neicon.ruЧалябиТ. А.ChalyabiT.noemail@neicon.ruЦомаИ. В.TioinaV.noemail@neicon.ruПрельУ. А.BrelY.noemail@neicon.ruПрохороваЕ. А.ProkhorovaE.noemail@neicon.ruВолгоградский государственный медицинский университетRussian Federation2006280220061215658Copyright © Недогода С.В., Чаляби Т.А., Цома И.В., Прель У.А., Прохорова Е.А., 20062006Недогода С.В., Чаляби Т.А., Цома И.В., Прель У.А., Прохорова Е.А.Nedogoda S., Chalyabi T., Tioina V., Brel Y., Prokhorova E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1046

Проведено сравнение клинической эффективности и переносимости фиксированных комбинаций Нолипрела форте и Ко-ренитека у больных АГ III ст, тяжести высокого и очень высокого риска, ненормализовавших АД на предшествующей ионотерапии. Исследование было ослепленным, рандомизированным («метод конвертов») с параллельными группами (по 20 человек в каждой). Больные получали в течение 6 месяцев по 1 таблетке утром Нолипрел форте (4 мг / 1,25 мг) и Ко-ренитек (20 мг / 12,5 мг). По своей антигипертензивной активности комбинации были сопоставимы между собой, а по способности уменьшать ГЛЖ и улучшать эластичность артерий фиксированная комбинация Нолипрел форте превосходилa фиксированную комбинацию Ко-ренитек. Аналогичная зависимость выявлена и в отношении показателя Т/Р.

The aim of the study was to compare i he clinical efficacy and tolerance of fixed combinations of angiotensin-converting enzyme (ACE) and diuretic noliprel and co-renitec in patients with mild and moderate arterial hypertension with high risk of cardiovascular events. All investigated patients didn't achieved normal AP level with monotherapy. The study was blinded, randomised and performed in parallel groups (20 subjects in each group). The clinical effects were evaluated after 6 months of therapy by 1 tablet of noliprel-forte (4 mg / 12.5 mg) or co-renitec (20 mg / 12.5 mg). The antihypertensive effect was comparable for both dings, but fixed combination of noliprel-forte show advantage in reducing of LV hypertrophy and improvement of arterial elasticity.

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The authors declare that there are no conflicts of interest present.