arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2006-12-2-156-160arthyper-1060Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПолиморфизм генов ренин-ангиотензиновой системы и рецептора брадикинина у детей и подростков с первичной артериальной гипертензиейAnalysis of polymorphisms of renin-angiotensin system and bradykinin receptor genes in children and adolescents with primary arterial hypertensionОбразцоваГ. И.ObraztsovaG. I.noemail@neicon.ruГлотовА. Е.GlotovA. S.noemail@neicon.ruСтепановаТ. В.StepanovaT. V.noemail@neicon.ruИващенкоТ. Э.IvashchenkoT. E.noemail@neicon.ruКовалевЮ. Р.KovalevY. R.noemail@neicon.ruГосударственная педиатрическая медицинская академияРоссияSt-Petersburg State Medical Pediatric AcademyRussian FederationНИИ акушерства и гинекологии им. Д.О. Отта РАМНРоссияOtt’s Institute of Obstetrics and Gynecology RAMSRussian Federation200628042006122156160Copyright © Образцова Г.И., Глотов А.Е., Степанова Т.В., Иващенко Т.Э., Ковалев Ю.Р., 20062006Образцова Г.И., Глотов А.Е., Степанова Т.В., Иващенко Т.Э., Ковалев Ю.Р.Obraztsova G.I., Glotov A.S., Stepanova T.V., Ivashchenko T.E., Kovalev Y.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1060

Обследовано 179 ребенка и подростка с первичной АГ и 158 школьников (9-17 лет). У всех детей изучен семейный анамнез по сердечно-сосудистой патологии. Детям с АГ было проведено суточное амбулаторное мониторирование АД. У всех детей исследованы: A1983G полиморфизм гена ренина (REN), М235Т полиморфизм гена ангиотензиногена (AGT), Ι/D полиморфизм гена ангиотензин-превращающего фермента (АСЕ), А1166С полиморфизм гена рецептора ангиотензина II 1-го типа (AGTR1), А3123С полиморфизм гена рецептора ангиотензина II 2-го типа (AGTR2), Т58С и Ι/D полиморфизм гена рецептора брадикинина-2 (BKR2). Обнаружено достоверное увеличение частоты аллели А полиморфизма A1983G гена REN у детей со стабильной АГ по сравнению с контрольной группой. В группе детей со стабильной АГ, по сравнению с детьми, имеющими гипертензию белого халата и лабильную АГ, обнаружено статистически достоверное преобладание аллели Т полиморфизма М235Т гена AGT. У детей с АГ, имеющих родственников больных ИБС, частота аллели А полиморфизма А1166С гена AGTR1 достоверно увеличена в сравнении с контрольной группой. Не обнаружено достоверных различий в распределении аллельных частот Ι/D полиморфизма гена АСЕ и А3123С полиморфизм гена AGTR2 между детьми с АГ и контролем. При сравнении детей с АГ и контрольной группы частоты аллелей двух полиморфных вариантов гена BKR2 достоверно не различались. В тоже время у мальчиков с АГ обнаружено достоверное увеличение аллели С полиморфизма Т58С.

We inspected 179 children and adolescents aged 9-17 years with primary arterial hypertension (AH) and 158 schoolchildren aged 7-17 years. All the hypertensive children underwent 24 hour ABPM. Family history of all the children was studied in particular of cardiovascular diseases. The 19-83G/A polymorphism of renin gene (REN), the M235T polymorphism of the angiotensinogen gene (AGT), the I/D polymorphism of angiotensin converting gene (ACE), the Al 166C polymorphism of angiotensin II type 1 receptor (AGTR1) gene, the C3123A polymorphism of angiotensin II type 2 receptor gene (AGTR2), I/D and T/С polymorphisms of the bradykinin receptor 2 gene (BKR2), were analyzed. We found out the significant increase of A allele and genotype AA of 19-83G/A polymorphism of gene REN frequencies of the children with stable AH in comparison with control group. In the group of children with stable hypertension - in comparison with the group of children, who has white coat hypertension and labile AH, we found out statistically significant prevalence of T allele the M235T polymorphism of the gene AGT. Distribution of I/D polymorphisms frequencies for ACE and BKR genes was similar in children and adolescents with primary AH compared to control group. The children with AH, who had relatives with coronary disease, had significant increase of A allele and genotype AA polymorphism A1166C of gene AGTR1 frequencies. We did not find out significant differences in distribution of A and С alleles of C3123A polymorphism of gene AGTR2 between the hypertensive children and control group. The males with AH had significant distribution difference of alleles polymorphism T58C gene BKR2 with allele С increase.

артериальная гипертензияренин-ангиотензиновая системарецептор брадикининадетиarterial hypertensionrenin-angiotensin systembradykinin receptorchildrenReferencesGene polymorphisms of the renin-angiotensin-aldosterone system and essential arterial hypertension in childhood.Petrovie D, Bidovec M, Peterlin B.// Folia Biol (Krakow). 2002;50(1-2):53-6.Gene polymorphisms of the renin-angiotensin-aldosterone system and essential arterial hypertension in childhood.Petrovie D, Bidovec M, Peterlin B.// Folia Biol (Krakow). 2002;50(1-2):53-6.Renin-angiotensin gene polymorphism in children with uremia and essential hypertension.Papp F, Friedman AL, Bereczki C, Haszon I, Kiss E, Endrefiy E, Turi S.// Pediatr Nephrol. 2003 Feb;18(2):150-4. Epub 2002 Dec 18.Renin-angiotensin gene polymorphism in children with uremia and essential hypertension.Papp F, Friedman AL, Bereczki C, Haszon I, Kiss E, Endrefiy E, Turi S.// Pediatr Nephrol. 2003 Feb;18(2):150-4. Epub 2002 Dec 18.Глотов А.С., Наседкина Т.В., Иващенко Т.Э., Юрасов Р.А., Суржиков С.А., Паньков С.В., Чудинов А.В., Баранов В.С., Заседателев А.С. Создание биочипа для анализа полиморфизма в генах системы биотрансформации // Молекулярная биология 2005. Т. 39. №3. Стр. 403-412.Глотов А.С., Наседкина Т.В., Иващенко Т.Э., Юрасов Р.А., Суржиков С.А., Паньков С.В., Чудинов А.В., Баранов В.С., Заседателев А.С. Создание биочипа для анализа полиморфизма в генах системы биотрансформации // Молекулярная биология 2005. Т. 39. №3. Стр. 403-412.National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Fourth Report on the Diagnosis, Evaluation, and Treatment High Blood Pressure in Children and AdolescentsPediatrics - 2004. Vol. 114, №2, Aug. - P. 555-576National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Fourth Report on the Diagnosis, Evaluation, and Treatment High Blood Pressure in Children and AdolescentsPediatrics - 2004. Vol. 114, №2, Aug. - P. 555-576Soergel M., Kirschstein M., Busch C. et al. Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects//J.Pediatr 1997; 130: 2: 178-184.Soergel M., Kirschstein M., Busch C. et al. Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects//J.Pediatr 1997; 130: 2: 178-184.Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков. Методические рекомендации. Приложение 1 к журналу «Педиатрия имени Г.Н. Сперанского» (№2/2003 г.), с. 10.Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков. Методические рекомендации. Приложение 1 к журналу «Педиатрия имени Г.Н. Сперанского» (№2/2003 г.), с. 10.Frossard P.M., Malloy M.J., Lestringant G.G., Kane J.P. Haplotypes of the human renin gene associated with essential hypertension and stroke//J Hum Hypertens. 2001 Jan; 15(1): 49-55.Frossard P.M., Malloy M.J., Lestringant G.G., Kane J.P. Haplotypes of the human renin gene associated with essential hypertension and stroke//J Hum Hypertens. 2001 Jan; 15(1): 49-55.Ahmad U., Saleheen D., Bokhari A., Frossard P.M. Strong association of a renin intronic dimorphism with essential hypertension.// Hypertens Res. 2005 Apr;28(4):339-44.Ahmad U., Saleheen D., Bokhari A., Frossard P.M. Strong association of a renin intronic dimorphism with essential hypertension.// Hypertens Res. 2005 Apr;28(4):339-44.Renin-angiotensin-aldosterone system loci and multilocus interactions in young-onset essential hypertension.Porto PI, Garcia SI, Dieuzeide G, Gonzalez C, Pirola CJ.// Clin Exp Hypertens. 2003 Feb;25(2):l 17-30Renin-angiotensin-aldosterone system loci and multilocus interactions in young-onset essential hypertension.Porto PI, Garcia SI, Dieuzeide G, Gonzalez C, Pirola CJ.// Clin Exp Hypertens. 2003 Feb;25(2):l 17-30Tamaki S., Nakamura Y., Tsujita Y., Nozaki A., Amamoto Κ., Kadowaki T., Kita Y., Okamura T., Iwai N., Kinoshita M., Ueshima H. Polymorphism of the angiotensin converting enzyme gene and blood pressure in a Japanese general population (the Shigaraki Study) // Hypertens. Res. 2002. V. 25(6). P. 843-848.Tamaki S., Nakamura Y., Tsujita Y., Nozaki A., Amamoto Κ., Kadowaki T., Kita Y., Okamura T., Iwai N., Kinoshita M., Ueshima H. Polymorphism of the angiotensin converting enzyme gene and blood pressure in a Japanese general population (the Shigaraki Study) // Hypertens. Res. 2002. V. 25(6). P. 843-848.Yu H., Zhang Y., Liu G. Relationship between polymorphism of the angiotensin-converting enzyme gene and the response to angiotensin-converting enzyme inhibition in hypertensive patients // Hypertens. Res. 2003. V. 26(11). P. 881-886.Yu H., Zhang Y., Liu G. Relationship between polymorphism of the angiotensin-converting enzyme gene and the response to angiotensin-converting enzyme inhibition in hypertensive patients // Hypertens. Res. 2003. V. 26(11). P. 881-886.Fornage M., Amos C.I., Kardia S., Sing C.F., Turner S.T., Boerwinkle E. Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males // Circulation. 1998. V. 12,97(18). P. 1773-1779.Fornage M., Amos C.I., Kardia S., Sing C.F., Turner S.T., Boerwinkle E. Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males // Circulation. 1998. V. 12,97(18). P. 1773-1779.Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project. Castellano M, Glorioso N, Cusi D, Sarzani R, Fabris B, Opocher G, Zoccali C, Golin R, Veglio F, Volpe M, Mantero F, Fallo F, Rossi GP, Barlassina C, Tizzoni L, Filigheddu F, Giacche M, Rossi F; Molecular Genetic Study Group of the Italian Society of Hypertension. // J Hypertens. 2003 0ct;21(10): 1853-60.Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project. Castellano M, Glorioso N, Cusi D, Sarzani R, Fabris B, Opocher G, Zoccali C, Golin R, Veglio F, Volpe M, Mantero F, Fallo F, Rossi GP, Barlassina C, Tizzoni L, Filigheddu F, Giacche M, Rossi F; Molecular Genetic Study Group of the Italian Society of Hypertension. // J Hypertens. 2003 0ct;21(10): 1853-60.Unger T. The angiotensin type 2 receptor: variations on an enigmatic theme. J Hypertens, 1999; 17: 1775-86.Unger T. The angiotensin type 2 receptor: variations on an enigmatic theme. J Hypertens, 1999; 17: 1775-86.Schmieder RE, Erdmann J, Hilgers K, Delles C, Jacobi J, Fleck EV. Regitz-Zagrosek functional relevance of the human angiotensin II type 1 and type 2 receptor genes on left ventricular (lv) structure. Journal of Hypertension 1999;Schmieder RE, Erdmann J, Hilgers K, Delles C, Jacobi J, Fleck EV. Regitz-Zagrosek functional relevance of the human angiotensin II type 1 and type 2 receptor genes on left ventricular (lv) structure. Journal of Hypertension 1999;Mukae S., Itoh S., Aoki S., Iwata T., Nishio Κ., Sato R., Katagiri T. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough //J. Hum. Hypertens. 2002. V. 16(12). P. 857-863.Mukae S., Itoh S., Aoki S., Iwata T., Nishio Κ., Sato R., Katagiri T. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough //J. Hum. Hypertens. 2002. V. 16(12). P. 857-863.

The authors declare that there are no conflicts of interest present.