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Артериальная гипертензия

"Arterial’naya Gipertenziya" ("Arterial Hypertension")

1607-419X2411-8524

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arthyper-1067

Research Article

ОБЗОР

REVIEW

Позитронная эмиссионная томография как метод неинвазивной оценки миокардиального кровотока и коронарного резерва у пациентов с сердечно-сосудистой патологией (литературный обзор)

Positron emission tomography application for myocardial blood flow and coronary flow reserve measurement in patients with cardiovascular pathology

Рыжкова

Д. В.

Ryzhkova

D. V.

noemail@neicon.ru

Нифонтов

Е. М.

Nifontov

E. M.

noemail@neicon.ru

Тютин

Л. А.

Tyutin

L. A.

noemail@neicon.ru

ФГУ ЦНИРРИ Федерального агентства по здравоохранению и социальному развитиюРоссияCentral Research Institute of Roentgenology and RadiologyRussian Federation

СПбГМУ им.акад. И.П.ПавловаРоссияPavlov Medical State UniversityRussian Federation

2006

28062006

123200211

2006

Рыжкова Д.В., Нифонтов Е.М., Тютин Л.А.

Ryzhkova D.V., Nifontov E.M., Tyutin L.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://htn.almazovcentre.ru/jour/article/view/1067

Настоящая статья посвящена анализу литературных сведений, посвященных изучению патологии коронарного кровообращения при различных сердечно-сосудистых заболеваниях на основании результатов но-зитронной эмиссионной томографии (ПЭТ), Расчет миокардиального кровотока и коронарного резерва в различных отделах левого желудочка обеспечивает корректную оценку гемодинамической значимости коронарного атеросклероза. При патологических состояниях, ассоциирующихся с высоким риском развития сердечно-сосудистых заболеваний, коронарная недостаточность в подавляющем большинстве случаев обусловлена нарушением вазорелаксирующей функции эндотелия. Неинвазивная диагностика нарушений коронарной микроциркуляции играет важную роль в стратификации риска кардиоваскулярных осложнений. Особое значение приобретает исследование ПЭТ для объективной оценки эффективности медикаментозной терапии, направленной на коррекцию артериальной гипертензии, дислипидемии, сахарного диабета, гипоэстрогенемии. Нарушение коронарной микроциркуляции у пациентов с гипертрофической и идиопатической дилатационной формами кардиомиопатии является независимым предиктором коронарных осложнений и ассоциируется с высоким риском внезапной смерти.

This article summarizes data of the studies with positron emission tomography (PET) and devotes the clinical application of PET for myocardial blood flow and coronary flow reserve measurement in the patients with cardiovascular pathology. Measurement of myocardial blood flow and coronary flow reserve allows to assess the functional importance of coronary stenosis in patients with coronary heart disease. According the results of experimental and clinical studies the impairment of coronary vasomotor reactivity seems to be the main cause of coronary microcirculatory abnormalities in the patients with high risk of cardiovascular diseases. Noninvasive PET diagnostics of myocardial blood flow provides the valuable information for stratification of the risk of the severe cardiovascular complications. PET seems to be a good tool for assessment of the medical treatment efficiency of arterial hypertension, diabetes mellitus, hypercholesterolemia and hypoestrogenemia. Myocardial blood flow impairment is independent prognostic marker of future adverse cardiac events and sudden cardiac death in patients with hypertrophic cardiomyopathy and idiopathic dilated cardiomyopathy.

Позитронная эмиссионная томографиямиокардиальный кровотокишемическая болезнь сердцафакторы риска ишемической болезни сердцакардиомиопатии

Positron emission tomographymyocardial blood flowcoronary artery diseaserisk factors for coronary heart diseasecardiomyopathy

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The authors declare that there are no conflicts of interest present.