arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2006-12-3-216-221arthyper-1069Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESХарактеристика субклинического воспаления у больных с неосложненной артериальной гипертониейCharacteristics of subclinical inflammation in uncomplicated arterial hypertensionКобалаваЖ. Д.KobalavaZ. D.noemail@neicon.ruКотовскаяЮ. В.KotovskayaY. V.noemail@neicon.ruДоготарьО. А.DogotarO. A.noemail@neicon.ruВиллевальдеС. В.VillevaldeS. V.noemail@neicon.ruМирилашвилиТ. Ш.MirilashviliT. S.noemail@neicon.ruРоссийский университет дружбы пародов; ГКБ № 64, г. МоскваРоссияRussian Peoples’ Friendship University; Hospital N 64, MoscowRussian Federation200628062006123216221Copyright © Кобалава Ж.Д., Котовская Ю.В., Доготарь О.А., Виллевальде С.В., Мирилашвили Т.Ш., 20062006Кобалава Ж.Д., Котовская Ю.В., Доготарь О.А., Виллевальде С.В., Мирилашвили Т.Ш.Kobalava Z.D., Kotovskaya Y.V., Dogotar O.A., Villevalde S.V., Mirilashvili T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1069

Важная роль в прогрессировании сосудистых и органных нарушений при АГ принадлежит воспалению и окси-дативному стрессу. Цель исследования - изучить показатели неспецифического воспаления и оксидативного стресса у больных с неосложненной АГ I-III степени Материалы и методы. В исследование включено 59 мужчин и 55 женщин в возрасте от 30 до 65 лет с неосложненной первичной АГ I-III степени без предшествующей регулярной антигипертензивной терапии. Определены: показатели оксидативного стресса (малоновый диальдегид (МДА) сульфгидрильные группы (SH)), показатели воспаления (ФНО-α, ИЛ-lß, ИЛ-4, ИЛ-6, высокочувствительный С-реактивный белок (вчСРБ). Проанализирована их взаимосвязь с уровнем АД и традиционными факторами риска. Результаты. У 45% отмечено повышение концентрации хотя бы одного цитокина выше медианы. В 26,3% случаев повышение концентрации провоспалительных цитокинов сочеталось с низкими значениями антивоспалителыю-го коэффициента ИЛ-4/ИЛ-6, у 18,4% - с высокими. У 55% концентрации всех провоспалительных цитокинов были ниже медианы. У трети больных это сочеталось с низкими значениями ИЛ-4/ИЛ-6, у 18,4% - с высокими. При регрессионном анализе установлено, что показатели воспалительного и оксидативного статусов взаимосвязаны между собой, не зависят от пола и возраста больных и определяются уровнем диастолического АД, курением, дислипи-демией, активностью РАС. Выводы. У нелеченных больных с неосложненной АГ повышение уровня провоспалительных цитокинов может сочетаться как с низкими, так и с высокими концентрациями противовоспалительного ИЛ-4. Воспалительный и оксидативный статусы определяются гемодинамической нагрузкой, курением, дислипидемией, активностью РАС.

Objective. Inflammation and oxidative stress are important determinants for target organ damage in arterial hypertension. The aim of the study was to evaluate inflammatory and oxidative markers in uncomplicated arterial hypertension. Methods. Study population included 114 (59 male, age 30-65 years) untreated hypertensive non-diabetic patients without associated clinical conditions. Plasma concentrations of malonic dyaldehyde and SH-groups were evaluated as oxidative stress markers. Serum concentrations of ultrasensitive CRP, TNF-α, interleukins (IL) lß, 4 and 6 were measured. Correlation between oxidative stress, inflammatory markers, blood pressure and traditional risk factors was analyzed. Results. In 45% patients elevation at leas of one pro-inflammatory cytokine was found. In 26,3% this elevation was revealed together with low anti-inflammatory ration (IL-4/IL-6), in 18,4% - with high IL-4/IL-6. In 55% concentration of all pro-inflammatory cytokines was lower than median. In one third of patients low cytokines levels were observed together with low IL-4/IL-6, in 22% - with high IL-4/IL-6. Regression analysis revealed that inflammatory and oxidative status are unrelated to gender, age and determined by diastolic blood pressure, smoking, dyslipidemia and rennin-angiotensine system activity. Conclusion. In untreated hypertensive non-diabetic patients High levels of pro-inflammatory cytokines may coexist either with low or high intiinflammatory ratio of IL-4/IL-6. Inflammatory and oxidative status are determined haemodynamic load, smoking, dyslipidemia and rennin-angiotensine system activity.

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The authors declare that there are no conflicts of interest present.