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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2006-12-3-232-236</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1072</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Изоптин СР 240 - эффективный антигипертензивный и антиишемический препарат</article-title><trans-title-group xml:lang="en"><trans-title>Isoptin SR 240 - effective antihypertensive and antiishemic medication</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маколкин</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Makolkin</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московская медицинская академия им. И.М.Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Sechenov Medical academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2006</year></pub-date><volume>12</volume><issue>3</issue><fpage>232</fpage><lpage>236</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Маколкин В.И., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Маколкин В.И.</copyright-holder><copyright-holder xml:lang="en">Makolkin V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1072">https://htn.almazovcentre.ru/jour/article/view/1072</self-uri><abstract><p>В обзоре представлены данные о высокой антигипертензивпой эффективности и безопасности изоптина СР у больных артериальной гипертензией. Показаны результаты многочисленных сравнительных исследований, доказавших преимущества применения изоптина СР, обусловленные его метаболической нейтральностью, симпатоли-тическим и нефропротективным эффектами. </p></abstract><trans-abstract xml:lang="en"><p>The review describes data about high antihypertensive efficacy and safety of isoptin SR in patients with arterial hypertension. The results of numerous comparative studies show advantages of isoptin SR related to its metabolic neutrality, symphatolvtic and nephroprotective effects. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>антигипертензивная эффективность</kwd><kwd>симпатическая нервная система</kwd><kwd>метаболические влияния</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antihypertensive efficacy</kwd><kwd>symphatic nervous system</kwd><kwd>metabolic effect</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">A.Fleckenstein Verapamil. A Drug on the Threshold of the Next Decade // Wissenschaftenverlag Wellingsbüttel GmbH.-1992,- p.9-18.</mixed-citation><mixed-citation xml:lang="en">A.Fleckenstein Verapamil. 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