arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2006-12-4-352-357arthyper-1090Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESАртериальная гипертензия и эндотелиальная дисфункция при хронической болезни почекArterial hypertension and endothelial dysfunction in chronic kidney diseasesПанинаИ. Ю.PaninaI. Y.noemail@neicon.ruПетрищевН. Н.PetrichshtevN. N.noemail@neicon.ruСмирновА. В.SmirnovA. V.noemail@neicon.ruРумянцевА. Ш.RumyantsevA. Sh.noemail@neicon.ruДегтереваО. А.DegterevaO. A.noemail@neicon.ruСанкт-Петербургский государственный медицинский университет им. акад. И.П.ПавловаРоссияPavlov Medical UniversityRussian Federation200628082006124352357Copyright © Панина И.Ю., Петрищев Н.Н., Смирнов А.В., Румянцев А.Ш., Дегтерева О.А., 20062006Панина И.Ю., Петрищев Н.Н., Смирнов А.В., Румянцев А.Ш., Дегтерева О.А.Panina I.Y., Petrichshtev N.N., Smirnov A.V., Rumyantsev A.S., Degtereva O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1090

Артериальная гипертензия является важной причиной ипвалидизации и смерти больных с хронической болезнью почек (ХБП). Целью исследования было оценить особенности АГ, вазомоторной формы эндотелиальной дисфункции, уровня молекулы адгезии VCAM1 у больных ХБП в группах с достигнутым и не достигнутым целевым уровнем АД. У 70 пациентов удалось добиться целевого АД, а у 31 - нет. При обследовании больных применили комплекс биохимических, иммуноферментных и инструментальных методов. У всех пациентов выявлена вазомоторная форма дисфункции эндотелия. При достижении целевого уровня АД отмечено улучшение эндотелий-зави-симой вазодилатации в пробе с ацетилхолином. Концентрация VCAM1 была повышена только у больных с недостигнутым целевым АД. Данная группа отличалась более высокими цифрами АД, большей выраженностью ГЛЖ, увеличением размеров предсердий, а также величин комплекса интима-медиа, более низкой величиной скорости клубочковой фильтрации. Сделан вывод о том, что достижение целевого уровня АД способствует коррекции вазомоторной формы ДЭ.

Arterial hypertension is the important reason of the morbidity and mortality of the patients with chronic kidney disease. The aim of this study was to estimate the feature of the arterial hypertension, vasomotor form endothelial dysfunction and level of VCAM1 at patients with chronic kidney disease at groups with achievement and not achievement target arterial pressure. At the moment of the survey the target arterial pressure was achieved at 70 (1 group) and not achieved at 31 patients (2 group). During investigation it was applied the complex of biochemical, immune-enzyme and instrumental methods. The vasomotor form of endothelial dysfunction was detected at all of patients. The improvement of endothelium-dependent vasodilatation was defined at patients with achieved target arterial pressure. The VCAM1 concentration was elevated only at the patients 2 group. This group was differ from the 1 group with more high arterial pressure, left ventricular hypertrophy, atrium enlargement, complex intima-media enlargement, decrease glomerular filtration rate. It was made the conclusion that achievement target arterial pressure facilitate the correction of vasomotor form of endothelial dysfunction.

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The authors declare that there are no conflicts of interest present.