arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2007-13-2-119-127arthyper-1115Research ArticleОБЗОРREVIEWАссиметричный диметиларгинин в качестве медиатора и маркера развития эндотелиальной дисфункцииADMA as a marker and mediator of endothelial dysfunction progressionЖлобаА. А.ZhlobaA. A.noemail@neicon.ruОтдел биохимии НИЦ СПбГМУ им. И.П. ПавловаSt.-Petersburg State I.P. Pavlov Medical University200728042007132119127Copyright © Жлоба А.А., 20072007Жлоба А.А.Zhloba A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1115

Нарушение эндотелий - зависимой вазодилятации является одним из основных эффектов, возникающих при накоплении ассиметричного диметиларгинина (АДМА) и гомоцистеина в организме. Повышенный уровень АДМА в плазме крови может формироваться при умеренной форме гипергомоцистеинемии (ГГци). В большинстве случаев торможение eNOS иод, влиянием гомоцистеина возникает за счет ассиметричного диметиларгинина (АДМА), накапливающегося в эндотелиоцитах. Механизм этого явления, по-видимому, состоит в том, что гомоцистеин в клетке превращается в S-аденозилгомоцистеин - мощный ингибитор диметилар-гинин-диметиламиногидролазы (ДДАГ). Данные литературы указывают на то, что развитие эндотелиальной дисфункции может зависеть как от сочетания всех этих факторов, так и в отсутствие одного из них.

Impaired endothelium-dependent vasodilatation is one of a main effects followed from elevation ADMA and homocysteine. Homocyseine dependent inhibition of the enzymatic function of eNOS arises as associated event under the direct influence of ADMA elevation in endothelial cells. The cellular mechanism of this phenomenon, apparently, consists in transformation of homocysteine in S-adenosyl-homocysteine which inhibits dimethylarginine dimethylamino hydrolase (DDAH). The literature data show up dependence of endothelial vasomotor dysfunction development both from on a combination of these factors, and in case of one lack.

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The authors declare that there are no conflicts of interest present.