arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2007-13-3-208-211arthyper-1132Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESМорфологическая характеристика течения экспериментального инфаркта миокарда под воздействием гранулоцитарного колониестимулирующего фактораMorhological characteristics of exiperimental miocardial infarction after granulocyte growth factor injectionНутфуллинаТ. Х.NutfullinaТ. Н.noemail@neicon.ruКрутиковА. Н.KrutikovA. N.noemail@neicon.ruАминеваХ. К.AminevaH. K.noemail@neicon.ruСанкт-Петербургский государственный медицинский университет имени академика И.П.ПавловаRussian Federation200728062007133208211Copyright © Нутфуллина Т.Х., Крутиков А.Н., Аминева Х.К., 20072007Нутфуллина Т.Х., Крутиков А.Н., Аминева Х.К.Nutfullina Т.Н., Krutikov A.N., Amineva H.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1132

Исследовалось влияние Г-КСФ на процессы репарации миокарда у крыс. Оценивалась зона ишемического поражения II плотность сосудистой сети грануляционной ткани к 7-м суткам развития инфаркта. Протяженность инфаркта миокарда в группе животных, получавших Г-КСФ, и в контрольной группе была одинакова. 15 то же время количество капилляров и недифференцированных сосудов в формирующейся грануляционной ткани было существенно больше у животных, получавших препарат. Это подтверждает участие Г-КСФ в стимуляции ангиогенеза.

G-CSF effects on experimental myocardial infarction in rats have been studied. Morphometrical evaluation was performed of the infracted zone as well as of the density of capillary and undifferentiated vessels in the surrounding granulation (issue. By day 7 G-CSF had no influence on the size of the infracted area, but I he vessel density eras substantially increased following administration of G-CSF. Existing data on G CSF effects on angiogenesis art- controversial. The results obtained favor stimulatory effect оf G-CSF on angiogenesis in healing of the myocardial in fare I ion.

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The authors declare that there are no conflicts of interest present.