arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2007-13-4-297-307arthyper-1150Research ArticleКОНКУРС МОЛОДЫХ УЧЕНЫХ НА ЛУЧШУЮ НАУЧНУЮ РАБОТУСосудодвигательная функция эндотелия у больных ишемической болезнью сердца с желудочковыми нарушениями ритма, возникающими на фоне миокардиальной ишемииVasomotor function of endothelium in patients with coronary artery disease and ventricular arrhythmias occurring during myocardial ischemiaРудаковМ. М.RudakovM. M.noemail@neicon.ruФГУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова»РоссияAlmazov Federal Centre of Heart, Blood and Endocrinology, St. PetersburgRussian Federation200728082007134297307Copyright © Рудаков М.М., 20072007Рудаков М.М.Rudakov M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1150

Оценить состояние сосудодвигательной функции эндотелия у больных ИБС с желудочковыми нарушениями ритма (ЖНР), возникающими на фоне ишемии. Материал и методы: Обследовано 48 больных ИБС без выраженной артериальной гипертензии и симптомов хронической сердечной недостаточности (фракция выброса > 50 %) с электрокардиографическими признаками ишемии во время пробы с физической нагрузкой (ФИ) на велоэргометре, которые были разделены на 2 равные группы по признаку появления (I группа) или отсутствия (II группа) воспроизводимых ЖНР на пике ФН или в восстановительном периоде (ВП). Также были выполнены пробы с реактивной гиперемией плечевой артерии для оценки эндотелий-зависимой вазодилатации (ЭЗВД) и с нитроглицерином для оценки эндотелий-независимой вазодилатации (ЭНВД) с использованием ультразвука высокого разрешения и определение концентрации эндотелина-1 (ЭТ-1) в плазме методом иммуноферментного анализа. Результаты: В I группе больных ЭЗВД плечевой артерии оказалась достоверно меньше, а длительность ишемических изменений ЭКГ в ВП больше, чем во II группе. Не было выявлено достоверных различий в величинах плазменной концентрации ЭТ-1 между группами. Выводы: У больных ИБС с ЖНР, возникающими на фоне ишемии, сосудодвигательная функция эндотелия нарушена в большей степени, а ишемия в пробе с ФН сохраняется дольше, чем у больных ИБС без ЖНР

Purpose: To compare vasomotor endothelial function in patients with coronary artery disease (CAD) with and without VA occurring during myocardial ischemia. Methods: We studied 48 patients with CAD who had electrocardiographic signs of ischemia during ergometer exercise testing. All patients were divided into 2 equal groups: group I with VA occurred at peak exercise or during recovery and group II without VA. Exercise test duration was similar in the groups I and II. None of the patients had severe arterial hypertension, diabetes mellitus or signs of heart failure. Assessment of endothelial-dependent flow-mediated vasodilation (FMD) and endothelial-independent nitroglycerin-mediated vasodilation of brachial artery (BA) was performed using high-resolution ultrasound. Plasma endothelin-1 levels were measured by immunoassay method. Results: FMD of BA was lower and duration of ischemic changes of ECG during recovery was greater in the group I compared with group II. There were no significant differences in plasma ET-1 levels among the groups I and II. Conclusions: The patients with CAD and VA occurring during ischemia have FMD impaired to a greater degree and duration of ischemic changes of ECG in recovery longer compared with ones without VA.

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The authors declare that there are no conflicts of interest present.