arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2008-14-2-151-161arthyper-1205Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСубклиническое воспаление и окислительный статус у больных с нелеченым сахарным диабетом 2 типаSubclinical inflammation and redox status in untreated patients with type 2 diabetes mellitusКобалаваЖ.KobalavaZ.noemail@neicon.ruВиллевальдеС.VillevaldeS. V.noemail@neicon.ruИсиковаХ.IsikovaH. V.noemail@neicon.ruГудгалисН.GudgalisN.noemail@neicon.ruРоссийский университет дружбы ргародов, ГКБ № 64РоссияUniversity of Nations FriendshipRussian Federation200828042008142151161Copyright © Кобалава Ж., Виллевальде С.V., Исикова Х.V., Гудгалис Н., 20082008Кобалава Ж., Виллевальде С., Исикова Х., Гудгалис Н.Kobalava Z., Villevalde S.V., Isikova H.V., Gudgalis N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1205

Воспаление и окислительный стресс играют важную роль в развитии сахарного диабета 2 типа и его осложнений. Воспаление может быть связующим звеном между метаболическими нарушениями и сердечно-сосудистыми заболеваниями. Адипонектин обладает антиатерогенными и инсулинсенситизирующими свойствами. Целью исследования явилось изучение воспалительного и окислительного статуса, уровня адипонектина у больных с нелеченным сахарным диабетом 2 типа в зависимости от основных факторов риска. У 158 пациентов определены показатели воспаления (лейкоциты, интерлейкины ФНО-б, ИЛ-1в, ИЛ-4, ИЛ-6), мочевая кислота, адипонектин, параметры окислительного статуса (малоновый диальдегид, сульфгидрильпые группы). Мужской пол, дислипидемия, большее количество компонентов метаболического синдрома ассоциировались с повышением уровня мочевой кислоты и снижением уровня адипонектина. Нарушения углеводного и липидного обмена ассоциировались с изменениями окислительной активности, не оказывая влияния на антиокислительный ответ. Не обнаружено связи адипонектина с показателями воспаления. Выявлена связь маркеров воспаления и адипонектина с параметрами окислительного стресса. При регрессионном анализе установлено, что показатели воспаления и окислительного статуса не зависят от пола, возраста больных, курения, контроля артериального давления (АД) и определяются параметрами углеводного и липидного обмена.

Inflammation and oxidative stress play an important role in diabetes type 2 development and its complications. Inflammation is believed to be a connecting point between metabolic changes and cardiovascular diseases. The aim of the study was to investigate inflammation and oxidation as well as adiponectin level in untreated diabetic patients. In 158 patients the level of leucocytes, TNF-alfa, interleukins-1в, 4, and 6 were measured together with adiponectin, maalonic dialdegid, and sulfhydrated radicals. Male gender, dyslipidemia, metabolic syndrome were associated with increased level of uric acid and low level of adiponectin. Lipid and glucose metabolism abnormalities were related to oxidation activity without any association with antioxidation response. Adiponectin level was not related to inflammatory markers. Regression analysis revealed that inflammation markers and oxidative stress are not related to gender, age, smoking status and blood pressure but are determined by lipid and glucose metabolism.

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The authors declare that there are no conflicts of interest present.