arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2008-14-3-257-263arthyper-1237Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЭндотелиальная функция у больных гипертонической болезнью в условиях стресса, мышечной релаксации и их сочетанияEndothelial function in hypertensive patients under the conditions of stress, muscle relaxation and their combinationСуминА.SuminA.noemail@neicon.ruСуминаЛ.SuminaL. Y.noemail@neicon.ruГалимзяновД.GalimzyanovD.noemail@neicon.ruГУ Научно-производственная проблемная лаборатория реконструктивной хирургии сердца и сосудов СО РАМНРоссияRegion clinical hospitalRussian FederationГУЗ Областной клинический госпиталь для ветеранов войнРоссияRegion clinical hospitalRussian Federation200828062008143257263Copyright © Сумин А., Сумина Л.Y., Галимзянов Д., 20082008Сумин А., Сумина Л., Галимзянов Д.Sumin A., Sumina L.Y., Galimzyanov D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1237

С целью изучения влияния стресса, мышечной релаксации и их сочетания на эндотелий-зависимую вазодилатацию (ЭЗВД) у больных гипертонической болезнью нами обследовано 22 больных гипертонической болезнью 1 стадии (возраст 41,8+1,8 лет) и здоровые лица (n=16) в качестве контрольной группы, сопоставимые по полу и возрасту. Показатели центральной гемодинамики и кровотока в плечевой артерии до и во время теста с реактивной гиперемией (ТРГ) оценивали в исходном состоянии, во время устного счета, в состоянии мышечной релаксации и при их сочетании. Результаты исследования: Устный счет у здоровых лиц вызывал повышение частоты сердечных сокращений (ЧСС ) и систолического артериального давления (АД), но не влиял на состояние ЭЗВД в плечевой артерии. У больных гипертонической болезнью существенное возрастание ЧСС и АД при стрессе сопровождалось снижением вазодилататорной реакции на тест с реактивной гиперемией (до 5,15+0,75%). Состояние мышечной релаксации у здоровых приводило к более выраженной вазодилататорной реакции на тест с реактивной гиперемией (на 10,76+1,77%). У больных гипертонической болезнью снижение ЧСС и АД было еще более выраженным, при этом вазодилататорная реакция была сопоставима с исходной. Сочетание стресса и мышечной релаксации неодинаково влияло на ЭЗВД в группах: если в контроле произошло нивелирование вазодилалаторной реакции (прирост диаметра плечевой артерии составил 7,98+1,0%), то в основной группе стресс на фоне мышечной релаксации не обладал подобным действием (ЭЗВД составила 8,71+2,3%). Таким образом, нами выявлена зависимость ЭЗВД от стрессового состояния, так и от стресс-лимитирующих воздействий. Это может быть использовано в первичной и вторичной профилактике артериальной гипертензии.

Aim of the paper was to study the influence of stress, muscle relaxation and their combination on endothelium-dependent vasodilation (EDV) in hypertensive patients. We investigated 22 hypertensive patients of I stage (age 41,8+1,8 years) and healthy persons (n= 16) as control group comparable by sex and age. The central hemodynamic parameters and forearm blood flow estimated before and during the reactive hyperemia test (RHT) at initial condition, during the mental stress, muscle relaxation and their combination. Results: the mental stress caused in healthy people increased heart rate and systolic blood pressure, but did not influence on forearm EDV. In hypertensive patients increase of heart rate and blood pressure at mental stress was accompanied by decrease of EDV (up to 5,15±0,75%). The muscle relaxation condition in healthy individuals resulted in more expressed EVD (on 10,76±1,77%). In hypertensive patients heart rate and blood pressure reduction was even more expressed, thus, EDV was comparable with basal. The combination of stress and muscle relaxation unequally influenced on EVD in groups: if in the control disappearance of additional vasodilator reaction (EVD was 7,98+1,0%) has taken place, in the hypertensive group the stress with condition of muscle relaxation had no similar effect (EVD was 8,71 ±2,3%). Thus, we revealed dependence of EDV on both stress and stress-limiting influences. It can be used in primary and secondary prevention of arterial hypertension.

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The authors declare that there are no conflicts of interest present.