arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2008-14-3-264-269arthyper-1238Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИспользования СРАР-терапии на фоне медикаментозного лечения артериальной гипертензии у больных с синдромом апноэ во снеCPAP-therapy in pharmacologically-treated hypertensive patients with sleep apneaСвиряевЮ.SviryaevY. V.noemail@neicon.ruЗвартауН.ZvartauN.noemail@neicon.ruРотарьО.RotarO.noemail@neicon.ruКоростовцеваЛ.KorostovtcevaL.noemail@neicon.ruКонрадиА.KonradiA.noemail@neicon.ruКалинкинА.KalinkinA.noemail@neicon.ruФГУ «ФЦСКЭ им. В.А. Алмазова Росздрава»РоссияFederal Center of Heart, Blood and EndocrinologyRussian FederationГородская клиническая больница № 83РоссияFederal Center of Heart, Blood and EndocrinologyRussian Federation200828062008143264269Copyright © Свиряев Ю.V., Звартау Н., Ротарь О., Коростовцева Л., Конради А., Калинкин А., 20082008Свиряев Ю., Звартау Н., Ротарь О., Коростовцева Л., Конради А., Калинкин А.Sviryaev Y.V., Zvartau N., Rotar O., Korostovtceva L., Konradi A., Kalinkin A.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1238

Резистентность к антигипертензивной терапии больных артериальной гипертензей (АГ) с синдромом обструктивного апноэ во сне (СОАС) предполагает, что устранение нарушений дыхания во сне будет способствовать успеху в контроле артериального давления (АД). Отсутствие рекомендаций по тактике ведения таких больных и малое количество исследований, проведенных в данной популяции, и предопределило цель нашего исследования - изучить эффективность комбинации стандартизованной антигипертензивной и СРАР-терапии у больных АГ с СОАС. Материалы: в исследование было включено 60 амбулаторных или находящихся на стационарном обследовании больных, которые были разделены на 3 группы лечения: больные АГ с СОАС, получавшие комбинированную стандартизованную антигипертензивную терапию и СРАР-терапию; больные АГ с СОАС, получавшие только стандартизованную антигипертензивную терапию, и больные АГ, получавшие стандартизованную антигипертензивную терапию. Результаты: за 3 месяца наблюдения и лечения целевого уровня АД удалось достигнуть у 17 больных АГ и СОАС с комбинированной терапией, у 12 пациентов АГ и СОАС со стандартизованной антигипертензивной терапией и у 18 больных АГ без нарушений дыхания во сне, получавших стандартизованную антигипертензивную терапию. Заключение: в исследовании продемонстрировано, что комбинация антигипертензивной и СРАР-терапии у больных АГ с СОАС позволяет за более короткий промежуток времени и у большего количества пациентов достичь целевого уровня АД. Присоединение СРАР-терапии эффективно устраняет СОАС и позволяет уменьшить объем проводимой антигипертензивной терапии и повысить ее эффективность.

Correction of sleep disorders in hypertensive patients with obstructive sleep apnea (OSA) may improve response to treatment and facilitate achievement of target blood pressure (BP). Due to the absence of guidelines and insufficient number of studies in this patient population we decided to conduct a study in order to investigate efficacy of standard antihypertensive treatment in combination with CPAP therapy in hypertensive OSA patients. Population: The study enrolled 60 ambulatory or in-hospital hypertensive patients, which were assigned to 3 treatment groups: OSA patients on standard antihypertensive therapy in combination with CPAP; OSA patients on standard antihypertensive therapy alone; non-OSA patients on standard antihypertensive therapy. Results: After 3 months of treatment, 17 patients in the first group, 12 patients in the second group and 18 patients in the third group achieved target BP. Conclusion: Combination of standard antihypertensive treatment and CPAP in hypertensive OSA patients results in increase of proportion of patients on target and decrease of time to achievement of target BP. Due to effective OSA treatment, addition of CPAP therapy results in higher efficacy of antihypertensive therapy with decrease of the number/ dosages of antihypertensive drugs.

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The authors declare that there are no conflicts of interest present.