arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2008-14-4-347-355arthyper-1254Research ArticleОБЗОРREVIEWПозитронная эмиссионная томография в оценке состояния симпатической иннервации сердцаРositron emission tomography in assessment of heart sympathetic nervous systemРыжковаД. В.RyzhkovaD.d_ryjkova@mail.ruЗыковЕ. М.ZykovE. M.noemail@neicon.ruШляхтоЕ. В.ShlyakhtoE. V.noemail@neicon.ruФГУ «Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова», ФГУ «Российский научный центр радиологии и хирургических технологий»РоссияFederal Almazov Heart, Blood and Endocrinology Center, Russian Scientific Center of Radiology and Surgical TechnologyRussian Federation200828082008144347355Copyright © Рыжкова Д.В., Зыков Е.М., Шляхто Е.В., 20082008Рыжкова Д.В., Зыков Е.М., Шляхто Е.В.Ryzhkova D., Zykov E.M., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1254

Настоящая статья является обзором литературы за последние 10 лет и посвящена анализу радиофармацевтических препаратов и эффективности применения позитронной эмиссионной томографии (ПЭТ) для изучения состояния симпатической иннервации сердца у пациентов с сердечно-сосудистыми заболеваниями. По результатам экспериментальных и клинических исследований, ПЭТ с мечеными аналогами катехоламинов и лигандами адренергических рецепторов открывает широкие возможности для объективной оценки состояния симпатической нервной системы на всех этапах нейрогенной передачи при ишемической болезни сердца, сахарном диабете, сердечной недостаточности и генетически детерминированной некоронарогенной желудочковой аритмии. Отмечено прогностическое значение радионуклидной нейровизуализации при патологических состояниях, ассоциирующихся с высоким риском развития летальных осложнений.

This article summarizes data of the studies with the use of positron emission tomography (PET) and devotes technical aspects and clinical application of PET for assessment of the autonomic nervous system of the heart in patients with cardiac diseases. According to the results of experimental and clinical studies PET with radiolabeled сatecholamines and adrenoreceptor ligands provides us with information about alteration of cardiac sympathetic innervation at different steps of neurotransmission. It plays a key role in the progression of various heart diseases such as ischemia, diabetes mellitus, heart failure and noncoronary arrhythmia. Cardiac sympathetic neuronal PET imaging seems to be a good tool for the stratification of the risk of the severe cardiovascular complications.

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The authors declare that there are no conflicts of interest present.