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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">arthyper-1303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Непрямые антикоагулянты в лечении больных с фибрилляцией предсердий. Эффективность и безопасность 2-летней терапии</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сердечная</surname><given-names>Е. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Татарский</surname><given-names>Б. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Северный государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова Росмедтехнологий»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2008</year></pub-date><volume>14</volume><issue>1-S2</issue><fpage>104</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сердечная Е.В., Татарский Б.А., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Сердечная Е.В., Татарский Б.А.</copyright-holder><copyright-holder xml:lang="en">Сердечная Е.В., Татарский Б.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1303">https://htn.almazovcentre.ru/jour/article/view/1303</self-uri><abstract><p>В статье обобщен опыт 2-летней терапии НАКГ у больных с фибрилляцией предсердий. Доказано существенное снижение ТЭО до 1,7 % в году пациентов с восстановленным синусовым ритмом, получающих постоянную терапию НАКГ. Показана безопасность терапии НАКГ, выделены предикторы геморрагических осложнений.</p></abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>стратегия контроля и стратегия ритма</kwd><kwd>антикоагулянтная терапия</kwd><kwd>антитромбоцитарная терапия</kwd><kwd>варфарин</kwd><kwd>аспирин</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Длительная терапия непрямыми антикоагулянтами больных с мерцательной аритмией без поражения клапанов сердца (проспективное наблюдение)/Е.С. Кропачева, К.II. Панченко, Л.Б. Добровольский и др. //Кард. - 2001. - №. 7. - С. Ю 16.</mixed-citation><mixed-citation xml:lang="en">Длительная терапия непрямыми антикоагулянтами больных с мерцательной аритмией без поражения клапанов сердца (проспективное наблюдение)/Е.С. Кропачева, К.II. Панченко, Л.Б. Добровольский и др. //Кард. - 2001. - №. 7. - С. Ю 16.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">ACC/AHA/ESC 2000 Guidelines for the Management ol Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European I lean Rhythm Association and the Heart Rhythm Society //Circulation. - 2006. - Vol. 111. N 7. - P. 257 - P. 354.</mixed-citation><mixed-citation xml:lang="en">ACC/AHA/ESC 2000 Guidelines for the Management ol Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European I lean Rhythm Association and the Heart Rhythm Society //Circulation. - 2006. - Vol. 111. N 7. - P. 257 - P. 354.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for at rial fibrillation / M.C. Fang, Y. Chang. P.M. Hylek et al. // Ann Intern Med. - 2001. - Vol. 141. - P. 745-752.</mixed-citation><mixed-citation xml:lang="en">Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for at rial fibrillation / M.C. Fang, Y. Chang. P.M. Hylek et al. // Ann Intern Med. - 2001. - Vol. 141. - P. 745-752.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bungard T.J. Why do patients with atrial fibrillation noi receive warfarin?/ T.J. Bungard, W.A. Ghali, K.K. Teo // Arch. Intern. Med. - 2000. -Vol.160. - P. 41-6.</mixed-citation><mixed-citation xml:lang="en">Bungard T.J. Why do patients with atrial fibrillation noi receive warfarin?/ T.J. Bungard, W.A. Ghali, K.K. Teo // Arch. Intern. Med. - 2000. -Vol.160. - P. 41-6.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Flegel К. М. Risk of stroke in non-rheumatic atrial fibrillation./K. M. Flegel, M.J. Shipley, G. Rose//Lancet.-1987. -Vol.1.-P.526-529.</mixed-citation><mixed-citation xml:lang="en">Flegel К. М. Risk of stroke in non-rheumatic atrial fibrillation./K. M. Flegel, M.J. Shipley, G. Rose//Lancet.-1987. -Vol.1.-P.526-529.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gorter J. W. Major bleeding during anticoagulation alter cerebral ischemia: pattens and risk factors Stroke Prevention in Reversible Ischemia Trial (SPIRIT)/ J.W. Gorter //Neurology. - 1999.- Vol.53. - P. 1319-1327.</mixed-citation><mixed-citation xml:lang="en">Gorter J. W. Major bleeding during anticoagulation alter cerebral ischemia: pattens and risk factors Stroke Prevention in Reversible Ischemia Trial (SPIRIT)/ J.W. Gorter //Neurology. - 1999.- Vol.53. - P. 1319-1327.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hart R.G. Meta-analysis: antithrombotic therapy to preveni stroke in patients who have nonvalvular atrial fibrillation./R.C. Hart, L.A, Pearce, M.I. Aguilar// Ann. Intern. Med. - 2007. -Vol.140.- P.857-867.</mixed-citation><mixed-citation xml:lang="en">Hart R.G. Meta-analysis: antithrombotic therapy to preveni stroke in patients who have nonvalvular atrial fibrillation./R.C. Hart, L.A, Pearce, M.I. Aguilar// Ann. Intern. Med. - 2007. -Vol.140.- P.857-867.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hemorrhagic complications of oral anticoagulant therapy: results of prospective multicenter study ISCOAT (Italian Study of Complications of Oral Anticoagulant Therapy) / G. Palareti, N. Leali, S. Coecheri et al.// Hal.Cardiol. - 1997. - Vol. 27. - P. 237-243.</mixed-citation><mixed-citation xml:lang="en">Hemorrhagic complications of oral anticoagulant therapy: results of prospective multicenter study ISCOAT (Italian Study of Complications of Oral Anticoagulant Therapy) / G. Palareti, N. Leali, S. Coecheri et al.// Hal.Cardiol. - 1997. - Vol. 27. - P. 237-243.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">ISCOAT Study Group (Italian Study of Complications of Oral Anticoagulant Therapy). Oral anticoagulant therapy in patients with non-rheumatic atrial fibrillation and risk of bleeding. A Multicenter Inception Cohort Study /V. Pengo, С Legnani, F. Noventa//Thromb.Haemost. - 2001.- Vol.85. - P. 418-422.</mixed-citation><mixed-citation xml:lang="en">ISCOAT Study Group (Italian Study of Complications of Oral Anticoagulant Therapy). Oral anticoagulant therapy in patients with non-rheumatic atrial fibrillation and risk of bleeding. A Multicenter Inception Cohort Study /V. Pengo, С Legnani, F. Noventa//Thromb.Haemost. - 2001.- Vol.85. - P. 418-422.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Landefeld C. S. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors by factors knows at the start of outpatients therapy /'(.'.S, Landefeld, L. Goldman Am.J. Med. - 1989. - Vol.87. - P. 144 - 152.</mixed-citation><mixed-citation xml:lang="en">Landefeld C. S. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors by factors knows at the start of outpatients therapy /'(.'.S, Landefeld, L. Goldman Am.J. Med. - 1989. - Vol.87. - P. 144 - 152.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Risk factors for complications of chronic anticoagulation. A multicenter study. Warfarin Optimized Outpatient Follow-up Study Groop/ S.D. Finn, M. Memmel. D. Matin et al. //Ann. Intern. Med. - 1993. - Vol. 118. - P. 511-520.</mixed-citation><mixed-citation xml:lang="en">Risk factors for complications of chronic anticoagulation. A multicenter study. Warfarin Optimized Outpatient Follow-up Study Groop/ S.D. Finn, M. Memmel. D. Matin et al. //Ann. Intern. Med. - 1993. - Vol. 118. - P. 511-520.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Thrombolysis in myocardial infarction (TIMI)Trial phase: hemorrhagic manifestation and changes in plasma fibrinogen and the fihrinolitic system in patients treated with with recombinant tissue plasminogen activator and streptokinase А.К Rao, С. Prat, A. Berke et al.// J. Am. Coll. Cardiol. - 1988. - Vol.11.- P.1-11.</mixed-citation><mixed-citation xml:lang="en">Thrombolysis in myocardial infarction (TIMI)Trial phase: hemorrhagic manifestation and changes in plasma fibrinogen and the fihrinolitic system in patients treated with with recombinant tissue plasminogen activator and streptokinase А.К Rao, С. Prat, A. Berke et al.// J. Am. Coll. Cardiol. - 1988. - Vol.11.- P.1-11.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the Anticoagulation and Risk factors in Atrial Fibrillation (ATRIA) Study /A.S. Go, K.M. Hylek. L.H. Borowskv et al. // Ann. Intern. Med. - 1999. - Vol.131. - P.927-934.</mixed-citation><mixed-citation xml:lang="en">Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the Anticoagulation and Risk factors in Atrial Fibrillation (ATRIA) Study /A.S. Go, K.M. Hylek. L.H. Borowskv et al. // Ann. Intern. Med. - 1999. - Vol.131. - P.927-934.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf P.A. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingam Study. / P.A. Wolf, T.R. Dawber. E.Jr. Thomas el al. // Neurology. - 1978. - Vol.28. P.973-977.</mixed-citation><mixed-citation xml:lang="en">Wolf P.A. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingam Study. / P.A. Wolf, T.R. Dawber. E.Jr. Thomas el al. // Neurology. - 1978. - Vol.28. P.973-977.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
