arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2009-15-2-185-190arthyper-1339Research ArticleЛЕКЦИЯ ДЛЯ ВРАЧЕЙНифедипин ГИТС - «ниша» в современном лечении АГNifedipine GITS - a «niche» in the mod
ern antihypertensive therapyКонрадиА. О.KonradiA.noemail@neicon.ruФГУ "Федеральный центр сердца, крови и эндокринологии имени В.А. Алмазова"РоссияAlmazov federal heart, blood and endocrinology centreRussian Federation200928042009152185190Copyright © Конради А.О., 20092009Конради А.О.Konradi A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1339ReferencesGuidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) // J. Hypertens. - 2007. - Vol. 25. - P. 1105-1187.Guidelines for the Management of Arterial Hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) // J. Hypertens. - 2007. - Vol. 25. - P. 1105-1187.Law M.R ., Wald N.J ., Morris J.K ., Jordan R.E. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials // BMJ. - 2003. - Vol. 326, № 7404. - Р. 1427-1431.Law M.R ., Wald N.J ., Morris J.K ., Jordan R.E. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials // BMJ. - 2003. - Vol. 326, № 7404. - Р. 1427-1431.Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention/ Scientific statement // Circulation. - 2007. - Vol. 115. - P. 2761-2788.Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention/ Scientific statement // Circulation. - 2007. - Vol. 115. - P. 2761-2788.Ong K.L., Cheung B.M., Man Y.B., Lau C.P., Lam K.S. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004 // Hypertension. 2007. - Vol. 49. - P. 69-75.Ong K.L., Cheung B.M., Man Y.B., Lau C.P., Lam K.S. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004 // Hypertension. 2007. - Vol. 49. - P. 69-75.Franklin S.S., Jacobs M.J., Wong N.D., L'Italien G.J., Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III // Hypertension. - 2001. - Vol. 37. - P. 869-874.Franklin S.S., Jacobs M.J., Wong N.D., L'Italien G.J., Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III // Hypertension. - 2001. - Vol. 37. - P. 869-874.Lloyd-Jones D.M., Evans J.C., Larson M.G., O'Donnell C.J., Roccella E.J., Levy D. Differential control of systolic and diastolic blood pressure: factors associated with lack of blood pressure control in the community // Hypertension. - 2000. - Vol. 36. - P. 594-599.Lloyd-Jones D.M., Evans J.C., Larson M.G., O'Donnell C.J., Roccella E.J., Levy D. Differential control of systolic and diastolic blood pressure: factors associated with lack of blood pressure control in the community // Hypertension. - 2000. - Vol. 36. - P. 594-599.Franklin S.S., Gustin W. 4th, Wong N.D., Larson M.G., Weber M.A., Kannel W.B. et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study // Circulation. - 1997. - Vol. 96. - P. 308-315.Franklin S.S., Gustin W. 4th, Wong N.D., Larson M.G., Weber M.A., Kannel W.B. et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study // Circulation. - 1997. - Vol. 96. - P. 308-315.Franklin S.S., Khan S.A., Wong N.D., Larson M.G., Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study // Circulation. - 1999. - Vol. 100. - P. 354-360.Franklin S.S., Khan S.A., Wong N.D., Larson M.G., Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study // Circulation. - 1999. - Vol. 100. - P. 354-360.Turnbull F. Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials // Lancet. - 2003. - Vol. 362. - P. 1527-1535.Turnbull F. Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials // Lancet. - 2003. - Vol. 362. - P. 1527-1535.Wang J.G., Staessen J.A., Franklin S.S., Fagard R., Gueyffier F. Systolic and diastolic blood pressure lowering as determinants of cardiovascular outcome // Hypertension. - 2005. - Vol. 45. - P. 907-913.Wang J.G., Staessen J.A., Franklin S.S., Fagard R., Gueyffier F. Systolic and diastolic blood pressure lowering as determinants of cardiovascular outcome // Hypertension. - 2005. - Vol. 45. - P. 907-913.Dahlöf B., Sever P.S., Poulter N.R., Wedel H., Beevers D.G., Caulfield M. et al, for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial // Lancet. - 2005. - Vol. 366. - P. 895-906.Dahlöf B., Sever P.S., Poulter N.R., Wedel H., Beevers D.G., Caulfield M. et al, for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial // Lancet. - 2005. - Vol. 366. - P. 895-906.Qiu C., De Ronchi D ., Fratiglioni L. The epidemiology of the dementias: an update // Curr. Opin. Psychiatry. - 2007. - Vol. 20, № 4. - P. 380-385.Qiu C., De Ronchi D ., Fratiglioni L. The epidemiology of the dementias: an update // Curr. Opin. Psychiatry. - 2007. - Vol. 20, № 4. - P. 380-385.DeCarli. The role of cerebrovascular disease in dementia // Neurologist. - 2003. - Vol. 9. - P. 123-136.DeCarli. The role of cerebrovascular disease in dementia // Neurologist. - 2003. - Vol. 9. - P. 123-136.Fournier A., Messerli F.H., Achard J.M., Fernandez L. Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent clinical trials // J. Am. Coll. Сardiol. - 2004. - Vol. 43. - P. 1343-1347.Fournier A., Messerli F.H., Achard J.M., Fernandez L. Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent clinical trials // J. Am. Coll. Сardiol. - 2004. - Vol. 43. - P. 1343-1347.Poole-Wilson P.A., Lubsen J., Kirwan B.A., van Dalen F.J., Wagener G., Danchin N. et al. Coronary disease trial Investigating Outcome with Nifedipine gastrointestinal therapeutic system investigators. Effect of long-term nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomized controlled trail // Lancet. - 2004. - Vol. 364. - P. 849-857.Poole-Wilson P.A., Lubsen J., Kirwan B.A., van Dalen F.J., Wagener G., Danchin N. et al. Coronary disease trial Investigating Outcome with Nifedipine gastrointestinal therapeutic system investigators. Effect of long-term nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomized controlled trail // Lancet. - 2004. - Vol. 364. - P. 849-857.Lubsen J., Wagener G., Kirwan B.A., de Brouwer S., Poole-Wilson P.A. Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stale angina and hypertension: the ACTION trial // J. Hypertens. - 2005. - Vol. 23, № 3. - P. 641-648.Lubsen J., Wagener G., Kirwan B.A., de Brouwer S., Poole-Wilson P.A. Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stale angina and hypertension: the ACTION trial // J. Hypertens. - 2005. - Vol. 23, № 3. - P. 641-648.Mason R.P. Mechanisms of plaque stabilization for the dihydropyridine calcium channel blocker amlodipine: review of the evidence // Atherosclerosis. - 2002. - Vol. 165. - P. 191-199.Mason R.P. Mechanisms of plaque stabilization for the dihydropyridine calcium channel blocker amlodipine: review of the evidence // Atherosclerosis. - 2002. - Vol. 165. - P. 191-199.Motro M., Shemesh J. Calcium channel blocker slows the progression of early coronary calcification in hypertensive patients compared with diuretics // Hypertension. - 2001. - Vol. 37. - P. 1410-1403.Motro M., Shemesh J. Calcium channel blocker slows the progression of early coronary calcification in hypertensive patients compared with diuretics // Hypertension. - 2001. - Vol. 37. - P. 1410-1403.Simon A., Gariépy J., Moyse D., Levenson J. Different effects of nifedipine and co-amilozide on the progression of early carotid wall changes // Circulation. - 2001. - Vol. 103. - P. 2949-2954.Simon A., Gariépy J., Moyse D., Levenson J. Different effects of nifedipine and co-amilozide on the progression of early carotid wall changes // Circulation. - 2001. - Vol. 103. - P. 2949-2954.Virdis A., Taddei S., Burali S. et al. Nifedipine improves endothelium-dependent vasodilatation by restoring nitric oxide // Am. J. Hypertens. - 1999. - Vol. 12 (Suppl). - P. 57A.Virdis A., Taddei S., Burali S. et al. Nifedipine improves endothelium-dependent vasodilatation by restoring nitric oxide // Am. J. Hypertens. - 1999. - Vol. 12 (Suppl). - P. 57A.Hempel A., Lindschau C., Maasch C., Mahn M., Bychkov R., Noll T. et al. Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C // Circulation. - 1999. - Vol. 99. - P. 2523-2529.Hempel A., Lindschau C., Maasch C., Mahn M., Bychkov R., Noll T. et al. Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C // Circulation. - 1999. - Vol. 99. - P. 2523-2529.Ghiadoni L., Magagna A., Versari D., Kardasz I., Huang Y., Taddei S. et al. Different effect of antihypertensive drugs on conduit artery endothelial function // Hypertension. - 2003. - Vol. 41. - P. 1281-1286.Ghiadoni L., Magagna A., Versari D., Kardasz I., Huang Y., Taddei S. et al. Different effect of antihypertensive drugs on conduit artery endothelial function // Hypertension. - 2003. - Vol. 41. - P. 1281-1286.Verhaar M.C., Honing M.L., van Dam T., Zwart M., Koomans H.A., Kastelein J.J. et al. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids // Cardiovasc. Res. - 1999. - Vol. 42. - P. 752-760.Verhaar M.C., Honing M.L., van Dam T., Zwart M., Koomans H.A., Kastelein J.J. et al. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids // Cardiovasc. Res. - 1999. - Vol. 42. - P. 752-760.Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H. et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease // Circ. Res. - 2001. - Vol. 89. - P. E1-E7.Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H. et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease // Circ. Res. - 2001. - Vol. 89. - P. E1-E7.The ENCORE investigators. Effect of nifedipine and cerivastatine on coronary endothelial function in patients with coronary artery disease // Circulation. - 2003. - Vol. 107. - P. 422-428.The ENCORE investigators. Effect of nifedipine and cerivastatine on coronary endothelial function in patients with coronary artery disease // Circulation. - 2003. - Vol. 107. - P. 422-428.Croom K.F., Wellington K. Modified-Release Nifedipine. A Review of the Use of Modified-Release Formulations in the Treatment of Hypertension and Angina Pectoris // Drugs. - 2006. - Vol. 66. - P. 497-528.Croom K.F., Wellington K. Modified-Release Nifedipine. A Review of the Use of Modified-Release Formulations in the Treatment of Hypertension and Angina Pectoris // Drugs. - 2006. - Vol. 66. - P. 497-528.Grossman E., Messerli F.H. Effect of calcium antagonists on plasma norepinephrine levels, heart rate, and blood pressure // Am. J. Cardiol. - 1997. - Vol. 80. - P. 1453-1458.Grossman E., Messerli F.H. Effect of calcium antagonists on plasma norepinephrine levels, heart rate, and blood pressure // Am. J. Cardiol. - 1997. - Vol. 80. - P. 1453-1458.Binggeli C., Corti R., Sudano I., Luscher T.F., Noll G. Effects of chronic calcium channel blockade on sympathetic nerve activity in hypertension // Hypertension. - 2002. - Vol. 39. - P. 892-896.Binggeli C., Corti R., Sudano I., Luscher T.F., Noll G. Effects of chronic calcium channel blockade on sympathetic nerve activity in hypertension // Hypertension. - 2002. - Vol. 39. - P. 892-896.de Champlain J., Karas M., Nguyen P., Cartier P., Wistaff R., Toal C.B. et al. Different effects of nifedipine and amlodipine on circulating catecholamine levels in essential hypertensive patients // J. Hypertens. - 1998. - Vol. 16. - P. 1357-1369.de Champlain J., Karas M., Nguyen P., Cartier P., Wistaff R., Toal C.B. et al. Different effects of nifedipine and amlodipine on circulating catecholamine levels in essential hypertensive patients // J. Hypertens. - 1998. - Vol. 16. - P. 1357-1369.Devereux R.B., Palmieri V., Sharpe N., De Quattro V., Bella J.N., de Simone G. et al. Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension. The prospective randomized enalapril study evaluating regression of ventricular enlargement (PRESERVE) trial // Circulation. - 2001. - Vol. 104. - P. 1248-1254.Devereux R.B., Palmieri V., Sharpe N., De Quattro V., Bella J.N., de Simone G. et al. Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension. The prospective randomized enalapril study evaluating regression of ventricular enlargement (PRESERVE) trial // Circulation. - 2001. - Vol. 104. - P. 1248-1254.
The authors declare that there are no conflicts of interest present.