arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2009-15-2-203-208arthyper-1342Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESФибрилляция предсердий, амилоидоз, миокардит и вирусная инфекцияAtrial fibrillation, amyloidosis, myocarditis and viral infectionМитрофановаЛ. Б.MitrofanovaL.noemail@neicon.ruКудайбергеноваА. Г.KudaibergenovaA. G.noemail@neicon.ruАнтоноваИ. В.AntonovaI. V.noemail@neicon.ruФедеральный центр сердца, крови и эндокринологии им. В.А. АлмазоваРоссияAlmazov federal heart, blood and endocrinology centreRussian Federation200928042009152203208Copyright © Митрофанова Л.Б., Кудайбергенова А.Г., Антонова И.В., 20092009Митрофанова Л.Б., Кудайбергенова А.Г., Антонова И.В.Mitrofanova L., Kudaibergenova A.G., Antonova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1342

На операционном и аутопсийном материале правого предсердия, межпредсердной перегородки и левого желудочка 110 пациентов проведено полуколичественное гистологическое и иммуногистохимическое исследование с использованием антител к кальцинейрину, натрийуретическому пептиду, преальбумину, λ- и κ-легким цепям иммуноглобулинов, АА-вторичному амилоиду, Ki-67-антигену, VP1 энтеровирусов, HSV-1, цитомегаловирусу, LMP вируса Эпстайна-Барр, аденовирусу, парвовирусу В19. Случаи с длительно существующей персистирующей фибрилляцией предсердий характеризовались наличием миокардита, амилоидоза и присутствием в кардиомиоцитах антигенов энтеровирусов, парвовируса В19, реже аденовируса.

The semi-quantitative histologic and immunohistochemical analyses were carried out on the biopsy and autopsy samples of right atrium, interatrial septum and left ventricle of 110 patients. The antibodies against calcineurin, natriuretic peptide, prealbumin (transthyretin), λ- and κ-light chains, АА amyloid, Ki-67-antigen, VP1-antigen of enterovirus, herpes simplex virus, cytomegalovirus, LMP- antigen of Epstein-Barr virus, adenovirus, parvovirus B19 were used. All cases with persistent atrial fibrillation are characterized by myocarditis, amyloidosis signs and by the presence of enterovirus and parvovirus B19 antigens, and more rarely by adenovirus.

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The authors declare that there are no conflicts of interest present.