arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2009-15-4-440-444arthyper-1409Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESУровень лептина, распределение генотипов и встречаемость аллелей А19G полиморфизма гена лептина у пациентов с абдоминальным ожирениемLeptin levels and A19G leptin gene polymorphisms in patients with abdominal obesityБеляеваО. Д.BelyaevaO. D.

Санкт-Петербург

St Petersburg

noemail@neicon.ruБаженоваЕ. А.BazhenovaE. A.

Санкт-Петербург

St Petersburg

olga_bel@pisem.netБерезинаА. В.BerezinaA. V.

Санкт-Петербург

St Petersburg

noemail@neicon.ruБольшаковаО. О.BolshakovaO. O.

Санкт-Петербург

St Petersburg

noemail@neicon.ruЧубенкоЕ. А.ChubenkoE. A.

Санкт-Петербург

St Petersburg

noemail@neicon.ruГаранинаА. Е.GaraninaA. E.

Санкт-Петербург

St Petersburg

noemail@neicon.ruТимошинВ. Б.TimoshinV. B.

Санкт-Петербург

St Petersburg

noemail@neicon.ruЛарионоваВ. И.LarionovaV. I.

Санкт-Петербург

St Petersburg

noemail@neicon.ruБарановаЕ. И.BaranovaE. I.

Санкт-Петербург

St Petersburg

noemail@neicon.ruБерковичО. А.BerkovichO. A.

Санкт-Петербург

St Petersburg

ГОУ ВПО «Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитию»; ГОУ ВПО «Санкт-Петербургская государственная педиатрическая медицинская академия Федерального агентства по здравоохранению и социальному развитию»РоссияSt Petersburg State Medical University; St Petersburg State Pediatric AcademyRussian Federation200928082009154440444Copyright © Беляева О.Д., Баженова Е.А., Березина А.В., Большакова О.О., Чубенко Е.А., Гаранина А.Е., Тимошин В.Б., Ларионова В.И., Баранова Е.И., Беркович О.А., 20092009Беляева О.Д., Баженова Е.А., Березина А.В., Большакова О.О., Чубенко Е.А., Гаранина А.Е., Тимошин В.Б., Ларионова В.И., Баранова Е.И., Беркович О.А.Belyaeva O.D., Bazhenova E.A., Berezina A.V., Bolshakova O.O., Chubenko E.A., Garanina A.E., Timoshin V.B., Larionova V.I., Baranova E.I., Berkovich O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1409

В работе был определен уровень лептина у больных абдоминальным ожирением - носителей различных генотипов гена лептина. Обследовано 472 пациента в возрасте 30-55 лет. Уровень лептина определяли методом иммуноферментного анализа, полиморфизм A19G гена лептина - методом полимеразно-цепной реакции. У больных абдоминальным ожирением уровень лептина выше, чем у здоровых лиц (46,5 ± 1,7 нг/мл и 24,4 ± 3,56 нг/мл, p = 0,0001). У женщин уровень лептина выше, чем у мужчин (51,7 ± 1,8 и 29,7 ± 3,1 нг/мл, p < 0,0001). Уровень лептина у больных АО, носителей различных генотипов гена ЛН, не отличался. Среди больных АО было достоверно больше носителей GG генотипа, чем в общей популяции детей и подростков (р = 0,04).

Study objective was to evaluate leptin levels in patients with abdominal obesity - carriers of different genotypes of leptin gene. Material and methods: 472 patients aged 30-55 years with abdominal obesity were examined. Leptin level was determined by ELISA, A19G leptin gene polymorphism was evaluated by polymerase chain reaction. Results and conclusion. High leptin level is seen in patients with abdominal obesity (46,5±1,7 ng\ml vs 24,4±3,56 ng/ml in healthy subjects, p=0,0001). Leptin levels were higher in women than in men (51,7±1,8 vs 29,7±3,1 ng/ml, p<0,0001). Leptin levels in patients with abdominal obesity did not vary depending on different genotypes of leptin gene. In patients with abdominal obesity GG genotype was seen more often that in general population (p=0.04).

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The authors declare that there are no conflicts of interest present.