arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2009-15-5-575-579arthyper-1436Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЗначение тромбинемии у пациентов с аортальным стенозомSignificance of thrombinemia in patients with aortic valve stenosisГончароваН. С.GoncharovaN. S.noemail@neicon.ruМоисееваО. М.MoiseevaO. M.noemail@neicon.ruАлешинаГ. М.AleshinaG. M.noemail@neicon.ruШляхтоЕ. В.ShlyakhtoE. V.noemail@neicon.ruФГУ «Федеральный Центр сердца, крови и эндокринологии имени В.А. Алмазова Росмедтехнологий»Россия1Almazov Federal Heart, Blood and Endocrinology Centre, St PetersburgRussian FederationГУ НИИ экспериментальной медицины РАМН, Санкт-ПетербургРоссияRussia Research Institute of Experimental Medicine RAMS, St Petersburg, RussiaRussian Federation200928102009155575579Copyright © Гончарова Н.С., Моисеева О.М., Алешина Г.М., Шляхто Е.В., 20092009Гончарова Н.С., Моисеева О.М., Алешина Г.М., Шляхто Е.В.Goncharova N.S., Moiseeva O.M., Aleshina G.M., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1436

В работе обследовано 34 пациента с неревматическим аортальным стенозом до и через 6 месяцев после протезирования аортального клапана механическим протезом типа МЕДИНЖ. Установлено, что процессы воспаления, активация тромбоцитарного и коагуляционного звеньев гемостаза тесно взаимосвязаны между собой и с процессами ремоделирования миокарда левого желудочка у пациентов с аортальным стенозом. Выявлена отрицательная корреляционная связь между регрессом гипертрофии левого желудочка после протезирования аортального клапана и тромбинемией.

4 patients with non-rheumatic aortic valve stenosis were assessed before the aortic valve replacement and 6 month the operation. It was found out that inflammation, thrombocytes and coagulation activation tightly interacted with each other and with left ventricular remodeling. There is a negative correlation between left ventricular hypertrophy regression thrombin level in plasma. Key words: aortic stenosis, thrombin, myocardial hypertrophy, inflammation, thrombocytes.

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The authors declare that there are no conflicts of interest present.