arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2010--5-arthyper-1479Research ArticleОБЗОРREVIEWЛокальныежировые депо как фактор риска сердечно-сосудистых заболеванийLocal fat depots asa cardiovascular risk factorЧумаковаГ. А.ChumakovaG. A.g.a.chumakova@mail.ruВеселовскаяН. Г.VeselovskayaN. G.noemail@neicon.ruКозаренкоА. А.KоzarenkoA. A.noemail@neicon.ruБарбарашЛ. С.BarbarashL. S.noemail@neicon.ruАлтайский государственный медицинский университетРоссияAltay State Medical University, Barnaul; Cardiology Research Center, KemerovoRussian FederationНаучно-исследовательский институт Комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМНРоссияCardiology Research Center, Kemerovo; Altay Regional Cardiology Prophylactic Center, BarnaulRussian FederationНаучно-исследовательский институт Комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМНРоссияCardiology Research Center, KemerovoRussian FederationАлтайский краевой кардиологический диспансерРоссияCardiology Research Center, KemerovoRussian Federation201028102010165441448Copyright © Чумакова Г.А., Веселовская Н.Г., Козаренко А.А., Барбараш Л.С., 20102010Чумакова Г.А., Веселовская Н.Г., Козаренко А.А., Барбараш Л.С.Chumakova G.A., Veselovskaya N.G., Kоzarenko A.A., Barbarash L.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1479

Ожирение ассоциируется с риском развития сердечно-сосудистой патологии. Одним из механизмов, ведущих к сердечно-сосудистым осложнениям является гормональная активность локальных жировых депо. Белая жировая ткань, расположенная в эпикардиальной, висцеральной, паранефральной и периваскулярной областях, оказывает не только локальное механическое воздействие на рядом расположенные органы, но и системное действие через биологически активные вещества. Проатерогенные и провоспалительные хемокины и цитокины вызывают хроническое воспаление сосудистой стенки, пролиферацию и миграцию гладкомышечных клеток, трансформацию моноцитов в макрофаги, что ведет к дисфункции эндотелия, формированию атеросклеротической бляшки и прогрессированию атеросклероза.

It is well known, that obesity is always associated with high risk of cardiovascular diseases. One of the mechanisms leading to the cardiovascular complications is hormonal activity of local fat depots. White adipose tissue, located in epicardial, visceral, paranephral and perivascular regions, provide not only local mechanic influence on nearby organs, but a systemic activity with help of bioactive substances. Pro-atherogenic and pro-inflammatory chemokines and cytokines lead to chronic inflammation of vascular side, proliferation and migration of smooth muscle cells, transformation monocytes to macrophages. And in the end, it results in endothelial dysfunction, atherosclerosis plaques formation and acceleration of atherosclerosis progression.

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The authors declare that there are no conflicts of interest present.