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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2010--5-</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1481</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Артериальная гипертония ипочечная недостаточность: применениеингибитора ангиотензинпревращающегофермента периндоприла</article-title><trans-title-group xml:lang="en"><trans-title>Angiotensin converting enzymeinhibitor Perindopril in arterial hypertension andrenal failure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гапон</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gapon</surname><given-names>L. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Тюменский кардиологический центр - филиал НИИ кардиологии СО РАМН<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2010</year></pub-date><volume>16</volume><issue>5</issue><fpage>457</fpage><lpage>463</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гапон Л.И., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Гапон Л.И.</copyright-holder><copyright-holder xml:lang="en">Gapon L.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1481">https://htn.almazovcentre.ru/jour/article/view/1481</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Томилина Н.А., Битбов Б.Т. Эпидемиология хронической почечной недостаточности и новые подходы к классификации и оценке тяжести хронических прогрессирующих заболеваниях почек // Терапевт. арх. - 2005. - Т. 6. - С. 87-92.</mixed-citation><mixed-citation xml:lang="en">Томилина Н.А., Битбов Б.Т. Эпидемиология хронической почечной недостаточности и новые подходы к классификации и оценке тяжести хронических прогрессирующих заболеваниях почек // Терапевт. арх. - 2005. - Т. 6. - С. 87-92.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Виллевальде С.В. АГ и функция почек. Вопросы и ответы. Часть 1. Учеб.-метод. пособие для врачей. - М., 2007. - 12 с.</mixed-citation><mixed-citation xml:lang="en">Кобалава Ж.Д., Виллевальде С.В. АГ и функция почек. Вопросы и ответы. Часть 1. Учеб.-метод. пособие для врачей. - М., 2007. - 12 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Остроумова О.Д. Почки - орган-мишень артериальной гипертонии: современные возможности нефропротекции // Мед. совет. - 2007. - № 1. - C.</mixed-citation><mixed-citation xml:lang="en">Остроумова О.Д. Почки - орган-мишень артериальной гипертонии: современные возможности нефропротекции // Мед. совет. - 2007. - № 1. - C.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Кутырина И.М., Михайлов А.А. Почка и артериальная гипертензия // Нефрология: Рук-во для врачей / Под ред. И.С. Тареевой. - М.: Медицина, 2000. - С. 164-188.</mixed-citation><mixed-citation xml:lang="en">Кутырина И.М., Михайлов А.А. Почка и артериальная гипертензия // Нефрология: Рук-во для врачей / Под ред. И.С. Тареевой. - М.: Медицина, 2000. - С. 164-188.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope L.M., Alcazar J.M., Rodicio J.I. Renal conseguences of arterial hypertension // J. Hypertens. - 1992. - № 10. - P. 85-90.</mixed-citation><mixed-citation xml:lang="en">Ruilope L.M., Alcazar J.M., Rodicio J.I. Renal conseguences of arterial hypertension // J. Hypertens. - 1992. - № 10. - P. 85-90.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А., Фомин В.В. Руководство по артериальной гипертонии. М., 2005. - C.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А., Фомин В.В. Руководство по артериальной гипертонии. М., 2005. - C.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А. (ред). Нефрология. Национальное руководство. - 2009. - 720 c.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А. (ред). Нефрология. Национальное руководство. - 2009. - 720 c.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Функциональное состояние почек и прогнозирование сердечно-сосудистого риска. Российские рекомендации // Кардиоваск. терапия и профилактика. - 2008. - Т. 7, № 6, прил. 3. -</mixed-citation><mixed-citation xml:lang="en">Функциональное состояние почек и прогнозирование сердечно-сосудистого риска. Российские рекомендации // Кардиоваск. терапия и профилактика. - 2008. - Т. 7, № 6, прил. 3. -</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ратова Л.Г., Чазова И.Е. Нефропротективный эффект антигипертензивной терапии: исследование ИРИС // Consilium medicum. - 2004. - № 2. - С. 3-6.</mixed-citation><mixed-citation xml:lang="en">Ратова Л.Г., Чазова И.Е. Нефропротективный эффект антигипертензивной терапии: исследование ИРИС // Consilium medicum. - 2004. - № 2. - С. 3-6.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Диагностика и лечение артериальной гипертензии. Российские рекомендации (третий пересмотр) // Кардиоваск. терапия и профилактика. - 2008ю - Т. 7, № 6, прил. - С.</mixed-citation><mixed-citation xml:lang="en">Диагностика и лечение артериальной гипертензии. Российские рекомендации (третий пересмотр) // Кардиоваск. терапия и профилактика. - 2008ю - Т. 7, № 6, прил. - С.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Кутырина И.М., Лифшиц Н.Л., Рогов В.А. и др. Применение ингибиторов ангиотензинпревращающего фермента при хронической почечной недостаточности // Терапевт. арх. - 2002. - № 6. - С. 34-39.</mixed-citation><mixed-citation xml:lang="en">Кутырина И.М., Лифшиц Н.Л., Рогов В.А. и др. Применение ингибиторов ангиотензинпревращающего фермента при хронической почечной недостаточности // Терапевт. арх. - 2002. - № 6. - С. 34-39.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Сидоренко Б.А., Переображенский Д.В. Ингибиторы ангиотензин-превращающего фермента. - М., 1999. - 253 с.</mixed-citation><mixed-citation xml:lang="en">Сидоренко Б.А., Переображенский Д.В. Ингибиторы ангиотензин-превращающего фермента. - М., 1999. - 253 с.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vincent M., Marchard B., Remond G. et al. Synthesis and ACE inhibitory activity of stereoisomers of perindopril (S-9490) and perindoprilat (S-9780) // Drug Des. Discov. - 1992. - № 9. - P. 11-28.</mixed-citation><mixed-citation xml:lang="en">Vincent M., Marchard B., Remond G. et al. Synthesis and ACE inhibitory activity of stereoisomers of perindopril (S-9490) and perindoprilat (S-9780) // Drug Des. Discov. - 1992. - № 9. - P. 11-28.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Brugts J., Ferrari R., Simoons M. Inhibitor ACE perindopril in the treatment of cardiovascular disease // Expert Rev. Cardivasc. Ther. - 2009. -Vol. 7, № 4. - P. 345-360.</mixed-citation><mixed-citation xml:lang="en">Brugts J., Ferrari R., Simoons M. Inhibitor ACE perindopril in the treatment of cardiovascular disease // Expert Rev. Cardivasc. Ther. - 2009. -Vol. 7, № 4. - P. 345-360.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Alfakih K., Hall AS. Drug evaluation of perindopril // Expert Opin. Pharmacotherapy. - 2006. - Vol. 7, № 1. - P. 63-71.</mixed-citation><mixed-citation xml:lang="en">Alfakih K., Hall AS. Drug evaluation of perindopril // Expert Opin. Pharmacotherapy. - 2006. - Vol. 7, № 1. - P. 63-71.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari R., Pasanisi G., Notasrstefano P. et al. Specific properties and effect of perindopril in controlling the renin-angiotensin system // Am. J. Hypertens. - 2005. - Vol. 18, № 9 (Pt. 2). - P. 142-154.</mixed-citation><mixed-citation xml:lang="en">Ferrari R., Pasanisi G., Notasrstefano P. et al. Specific properties and effect of perindopril in controlling the renin-angiotensin system // Am. J. Hypertens. - 2005. - Vol. 18, № 9 (Pt. 2). - P. 142-154.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Blood pressure lowering treatment trialists collaboraton. Blood pressure-dependent and independent effects of agents that inhibit renin-angiotensin system // J. Hypertens. - 2007. - 25. - P. 951-958</mixed-citation><mixed-citation xml:lang="en">Blood pressure lowering treatment trialists collaboraton. Blood pressure-dependent and independent effects of agents that inhibit renin-angiotensin system // J. Hypertens. - 2007. - 25. - P. 951-958</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Remme WJ., Deckers JW., Fox KM., Ferrari R. et al. EUROPA Investigators. Secondery prevention of coronary disease with ACE inhibition-does blood pressure reduction with perindopril explain the benefits in EUROPA? // Cardovasc. Drugs Ther. - 2008. (Цит. по Brugts J., 2009).</mixed-citation><mixed-citation xml:lang="en">Remme WJ., Deckers JW., Fox KM., Ferrari R. et al. EUROPA Investigators. Secondery prevention of coronary disease with ACE inhibition-does blood pressure reduction with perindopril explain the benefits in EUROPA? // Cardovasc. Drugs Ther. - 2008. (Цит. по Brugts J., 2009).</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ceconi C., Francolini G., Olivares A. et al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE // Eur. J. Parmacol. - 2007. - Vol. 577, № 1-3. - P. 1-6.</mixed-citation><mixed-citation xml:lang="en">Ceconi C., Francolini G., Olivares A. et al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE // Eur. J. Parmacol. - 2007. - Vol. 577, № 1-3. - P. 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ceconi C., Francolini G., Bastianon D. et al. Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis in vivo and in vivo studies // Cardovasc. Drugs Ther. - 2007. - Vol. 21, № 6. - P. 423-429.</mixed-citation><mixed-citation xml:lang="en">Ceconi C., Francolini G., Bastianon D. et al. Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis in vivo and in vivo studies // Cardovasc. Drugs Ther. - 2007. - Vol. 21, № 6. - P. 423-429.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Bots M.I., Remme J.W., Luscher T.F. et al. ACE inhibition and endothelial function main finding of PERFECT, a sub-study of the EUROPA trial // Cardovasc. Drugs Ther. - 2007. - Vol. 21. - P. 269-279.</mixed-citation><mixed-citation xml:lang="en">Bots M.I., Remme J.W., Luscher T.F. et al. ACE inhibition and endothelial function main finding of PERFECT, a sub-study of the EUROPA trial // Cardovasc. Drugs Ther. - 2007. - Vol. 21. - P. 269-279.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Cark LT. Safety profile of perindopril // Am. J. Cardiol. - 2001. - Vol. 88, № 7A. - P. 36i-40i.</mixed-citation><mixed-citation xml:lang="en">Cark LT. Safety profile of perindopril // Am. J. Cardiol. - 2001. - Vol. 88, № 7A. - P. 36i-40i.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Perindopril: a major contribution to tht preventon and treatment of cardiovascular disease / Ed. by F. Ferrari &amp; R.M. Fox. - Volters Kluwer, 2008. - 154 p.</mixed-citation><mixed-citation xml:lang="en">Perindopril: a major contribution to tht preventon and treatment of cardiovascular disease / Ed. by F. Ferrari &amp; R.M. Fox. - Volters Kluwer, 2008. - 154 p.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Brugts J., Boersma E., Chonchoi M. et al. The cardioprotective effecs of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial // J. Am. Coll. Cardiol. - 2007. - Vol. 50. - P. 2148-2155.</mixed-citation><mixed-citation xml:lang="en">Brugts J., Boersma E., Chonchoi M. et al. The cardioprotective effecs of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial // J. Am. Coll. Cardiol. - 2007. - Vol. 50. - P. 2148-2155.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Кутырина И.М. Применение ингибитора ангиотензин- превращающего фермента при первичных поражениях почек и диабетической нефропатии // Consilium Medicum. - 2002. - Т. 7, № 4. - С. 331-333.</mixed-citation><mixed-citation xml:lang="en">Кутырина И.М. Применение ингибитора ангиотензин- превращающего фермента при первичных поражениях почек и диабетической нефропатии // Consilium Medicum. - 2002. - Т. 7, № 4. - С. 331-333.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Кутырина И.М. Острый вопрос: расхождения во взглядах терапевта, нефролога и кардиолога на нефропротекцию при АГ. Точка зрения нефролога. Материалы симпозиума «30 лет с ингибиторами АПФ: что дальше» в рамках Российского Национального конгресса «Человек и лекарство 2005». - C. 3-5.</mixed-citation><mixed-citation xml:lang="en">Кутырина И.М. Острый вопрос: расхождения во взглядах терапевта, нефролога и кардиолога на нефропротекцию при АГ. Точка зрения нефролога. Материалы симпозиума «30 лет с ингибиторами АПФ: что дальше» в рамках Российского Национального конгресса «Человек и лекарство 2005». - C. 3-5.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
