arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2014-20-6-478-491arthyper-151Research ArticleРЕДАКЦИОННАЯ СТАТЬЯEDITORIALНАРУШЕНИЯ СИСТЕМНОГО ОБМЕНА НЕОРГАНИЧЕСКОГО ФОСФАТА КАК НОВЫЙ КЛАСТЕР КАРДИОВАСКУЛЯРНЫХ РИСКОВSYSTEMIC DISORDERS OF INORGANIC PHOSPHATE EXCHANGE AS A NOVEL CLUSTER OF CARDIOVASCULAR RISK FACTORSДобронравовВ. А.DobronravovV. A.

Доктор медицинских наук, профессор, заместитель директора ПСПбГМУ им.  И. П. Павлова.

Контактная информация: Добронравов Владимир Александрович, Научно-исследовательский институт нефрологии,  ГБОУ ВПО ПСПбГМУ им. И. П. Павлова Минздрава России,ул. Л. Толстого, д. 17, Санкт-Петербург,Россия, 197022.Тел.: +7(812)234–66–56.E-mail: dobronravov@nephrolog.ru

Сorresponding author:Vladimir A. Dobronravov,MD, PhD, DMSc, Professor, Research instituteof Nephrology, First Pavlov State Medical University of St. Petersburg, 17 L. Tolstoystreet, St Petersburg, 197022, Russia.Tel.: +7(812)234–66–56. E-mail: dobronravov@nephrolog.ru

dobronravov@nephrolog.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова, Санкт-ПетербургРоссияFirst Pavlov State Medical University of St. Petersburg,St PetersburgRussian Federation201406032015206478491Copyright © Добронравов В.А., 20152015Добронравов В.А.Dobronravov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/151

Исследования последней декады показали отчетливую связь между уровнем неорганического фосфата (Pi) сыворотки крови, а также нарушением баланса эндокринных систем почек, паращитовидных желез и костей, регулирующих обмен Pi, с сердечно-сосудистыми событиями и смертностью. Данные связи продемонстрированы для пациентов с хронической болезнью почек и для общей популяции. В передовой статье обсуждаются клинические и экспериментальные данные, объединяющие патофизиологию нарушений обмена Pi и развитие изменений в сердечно-сосудистой системе.

Recent studies have clearly linked higher serum inorganic phosphate (Pi) concentrations and an imbalance of Pi-regulation by kidney-bone-parathyroid endocrine systems to cardiovascular events and mortality. This association has been identified in patients with chronic kidney disease, as well as in general population. The editorial discusses the available clinical and experimental data linking the pathophysiology of phosphate exchange disorders and cardiovascular events.

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The authors declare that there are no conflicts of interest present.