arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2014-20-6-515-521arthyper-155Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLEХАРАКТЕР ИЗМЕНЕНИЯ СИМПАТИЧЕСКОЙ АКТИВНОСТИ К СЕРДЦУ И СОСУДАМПРИ РАЗВИТИИ ЭКСПЕРИМЕНТАЛЬНОЙ ВАЗОРЕНАЛЬНОЙ ГИПЕРТЕНЗИИ (2 ПОЧКИ — 1 ЗАЖИМ)CHANGES OF THE SYMPATHETIC ACTIVITY IN THE HEART AND VESSELS IN THE DEVELOPMENT OF EXPERIMENTAL VASORENAL HYPERTENSION (2 KIDNEYS — 1 CLIP)КузьменкоН. В.KuzmenkoN. V.

 Кандидат биологических наук, старший научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «ФМИЦ им. В. А. Алмазова» , лаборатории биофизики кровообращения ГБОУ ВПО ПСПбГМУ им. И. П. Павлова.

Контактная информация: Кузьменко Наталия Владимировна, ФГБУ «Федеральный медицинский исследовательский центр имени В.А. Алмазова» , ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341. E-mail: kuzmenko@niiekf.ru

Corresponding author: Natalia V. Kuzmenko, PhD of Biology Sciences, Federal Almazov Medical Research Centre, 2 Akkuratova street, St Petersburg, 197341 Russia. E-mail: kuzmenko@niiekf.ru

kuzmenko@niiekf.ruЩербинЮ. И.ShcherbinY. I.

PhD, Biology Sciences, Senior Researcher, Department of Experimental Physiology and Pharmacology;

Laboratory of Circulation Biophysics

kuzmenko@niiekf.ruПлиссМ. Г.PlissM. G.

MD, PhD, Head, Department of Experimental Physiology and Pharmacology;

Laboratory of Circulation Biophysics

kuzmenko@niiekf.ruЦырлинВ. А.TsyrlinV. A.

MD, PhD, DSc, Professor, Leading Researcher, Department of Experimental Physiology and Pharmacology;

Department of Pharmacology

kuzmenko@niiekf.ruФедеральный медицинский исследовательский центр имени В.А. Алмазова, Санкт-Петербург ; Первый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова, Санкт-ПетербургРоссияFederal Almazov Medical Research Centre, St Petersburg ; First Pavlov State Medical University of St. Petersburg, St PetersburgRussian Federation201406032015206515521Copyright © Кузьменко Н.В., Щербин Ю.И., Плисс М.Г., Цырлин В.А., 20152015Кузьменко Н.В., Щербин Ю.И., Плисс М.Г., Цырлин В.А.Kuzmenko N.V., Shcherbin Y.I., Pliss M.G., Tsyrlin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/155

Цель настоящего исследования заключалась в изучения динамики артериального давления и активности симпатической нервной системы у крыс линии Wistar на протяжении первых 8 недель развития вазоренальной гипертензии в модели «2 почки — 1 зажим».

 Материалы и методы

 Материалы и методы. Симпатическую активность к сердцу оценивали на бодрствующих животных методом спектрального анализа вариабельности сердечного ритма. Симпатическую вазомоторную активность оценивали путем регистрации электрической активности шейного симпатического ствола под наркозом у тех же крыс.

Результаты

Результаты. Оказалось, что динамика симпатической активности к сердцу и сосудам принципиально не различается. При этом обнаружено, что если через 2 недели после наложения зажима на почечную артерию активность симпатической нервной системы увеличивается, то через 4 недели она приближается к контрольным значениям при развитой гипертензии и затем снова возрастает до максимальных значений к концу эксперимента.

Выводы

Выводы. Таким образом, механизм артериальной гипертензии, возникающей после клипирования почечной артерии, имеет достаточно сложный характер, однако в конечном счете основное значение, по-видимому, имеет усиление активности вазомоторных нейронов спинного мозга.

Objective

Objective. To evaluate the dynamics of arterial blood pressure and sympathetic activity in the male Wistar rats within 8 weeks after renal artery clamping (model «2 kidneys — 1 clamp»).

Design and methods

Design and methods. The sympathetic activity was examined by spectral analysis of the heart rate variability in the non-anaesthesized rats. The sympathetic vasomotor activity was examined by the registration of electric activity of the cervical spine cord in anaesthesized animals.

 Results

 Results. We found that sympathetic activity to the heart and blood vessels is comparable. Two weeks after renal artery clamping the activity of the sympathetic nervous system increases, and 4 weeks later it comes close to the reference values in the developed hypertension and then increases to maximum values by the end of the experiment. 

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The authors declare that there are no conflicts of interest present.