Objeсtive. To assess the changes of vascular stiffness and central blood pressure in hypertensive patients on long-term antihypertensive therapy. Patients and methods. 84 subjects (56 women and 28 men) with hypertension and/or risk factors were screened. Mean age was 52,1 ± 10,6 years. Biochemistry (serum glucose and lipids), anthropometry, blood pressure (BP), arterial stiffness, central BP and ankle brachial index were assessed. Carotid ultrasound with estimation of intima-media thickness and echocardiography were performed. All patients were divided into 3 groups depending on the administered therapy: angiotensin converting enzyme (ACE) inhibitors (enalapril 5 mg, 52 subjects), beta-blockers (bisoprolol 5 mg, 22 subjects), calcium channel blockers (amlodipine 5 mg, 10 subjects). All parameters were assessed initially and after 3 and 12 months. To define age impact 2 subgroups were formed: 30-49 and 50-70 years old. Results. Arterial stiffness decreased after 3-month antihypertensive therapy, and no further changes were observed at long-term follow-up. The greatest decrease of the peripheral BP was observed in the group of ACE inhibitors, but central BP markedly decreased in calcium antagonists group. Patients over 50 years old had higher values of peripheral and central BP and subclinical target organ damage signs. Older patients showed better reversal of peripheral and central BP on antihypertensive therapy.