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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2011-17-4-384-390</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Оптимизация комбинированной антигипертензивной терапии при резистентной артериальной гипертензии</article-title><trans-title-group xml:lang="en"><trans-title>Rational combination therapy in resistant arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelianov</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives><email xlink:type="simple">ahleague@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Федеральный Центр сердца, крови и эндокринологии имени В.А. Алмазова» Минздравсоцразвития РФ, Санкт-Петербург</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2011</year></pub-date><volume>17</volume><issue>4</issue><fpage>384</fpage><lpage>390</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Емельянов И.В., Конради А.О., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Емельянов И.В., Конради А.О.</copyright-holder><copyright-holder xml:lang="en">Emelianov I.V., Konradi A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1642">https://htn.almazovcentre.ru/jour/article/view/1642</self-uri><abstract><p>В статье рассматривается проблема лечения пациентов с резистентной артериальной гипертензией, представлены современные подходы к подбору комбинированной терапии, использованию рациональных комбинаций препаратов.</p></abstract><trans-abstract xml:lang="en"><p>The article reviews therapy in drug-resistant hypertension. Current therapeutic approaches to treatment and rational combination therapy are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>резистентная артериальная гипертензия</kwd><kwd>комбинированная терапия</kwd><kwd>блокада ренин-ангиотензиновой системы</kwd><kwd>бета-адреноблокаторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>resistant arterial hypertension</kwd><kwd>combination therapy</kwd><kwd>renin-angiotensin system blockade</kwd><kwd>prognosis</kwd><kwd>beta-blockers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rayner M., Petersen S. European cardiovascular disease statistics. British Heart Foundation: London. - Available from: &lt;http://www.heartstats.org/homepage.asp&gt; [accessed on 12 February 2008].</mixed-citation><mixed-citation xml:lang="en">Rayner M., Petersen S. European cardiovascular disease statistics. 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