<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2011-17-5-415-424</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1647</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Гиполипидемическая терапия у пожилых пациентов. В фокусе — статины и прогноз</article-title><trans-title-group xml:lang="en"><trans-title>Lipid-lowering therapy in elderly patients: Focus on statins and outcome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барсуков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Barsukov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">avbarsukov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таланцева</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Talantseva</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свёклина</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sveklina</surname><given-names>T. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багаева</surname><given-names>З. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagaeva</surname><given-names>Z. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зобнина</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Zobnina</surname><given-names>M. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Военно-медицинская академия им. С.М. Кирова<country>Россия</country></aff><aff xml:lang="en">Military Medical Academy named after S.M. Kirov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2011</year></pub-date><volume>17</volume><issue>5</issue><fpage>415</fpage><lpage>424</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барсуков А.В., Таланцева М.С., Свёклина Т.С., Багаева З.В., Зобнина М.П., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Барсуков А.В., Таланцева М.С., Свёклина Т.С., Багаева З.В., Зобнина М.П.</copyright-holder><copyright-holder xml:lang="en">Barsukov A.V., Talantseva M.S., Sveklina T.S., Bagaeva Z.V., Zobnina M.P.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1647">https://htn.almazovcentre.ru/jour/article/view/1647</self-uri><abstract><p>Пожилой возраст и дислипидемия — безусловные факторы высокого риска сердечно-сосудистой заболеваемости и смертности. В статье приведены доказательства пользы применения статинов в интересах первичной и вторичной профилактики сердечно-сосудистых осложнений у лиц максимально старших возрастных групп. Показана важность достижения целевых уровней липидов независимо от возрастной принадлежности. Отражены возможности комбинированной липидснижающей терапии. Освещены вопросы безопасности применения статинов у лиц пожилого и старческого возраста.</p></abstract><trans-abstract xml:lang="en"><p>Elderly age and dyslipidemia are known high risk factors for cardiovascular morbidity and mortality. The article focuses on the evidence of statin benefits in primary and secondary prevention of cardiovascular complications in very elderly subjects. Importance of the achievement of target lipid levels regardless the age and possibilities of combined lipidlowering therapy in elderly patients are demonstrated. Some aspects of statin safety in elderly subjects are highlighted in the paper.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дислипидемия</kwd><kwd>пожилой возраст</kwd><kwd>статины</kwd><kwd>комбинированная липидснижающая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dyslipidemia</kwd><kwd>elderly age</kwd><kwd>statins</kwd><kwd>combined lipid-lowering therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">American Heart Association. Older Americans and cardiovascular diseases statistics. 2004. Available at: http://www.americanheart.org/down-loadi-theart/11365844954980lderAm06.pdf. Accessed August 2008.</mixed-citation><mixed-citation xml:lang="en">American Heart Association. Older Americans and cardiovascular diseases statistics. 2004. Available at: http://www.americanheart.org/down-loadi-theart/11365844954980lderAm06.pdf. Accessed August 2008.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Frishman W.H. Management of hyperholesterinemia in older persons for the prevention of cardiovascular disease // Cardiol. Rev. — 2010. — Vol. 13, № 3. — Р. 132-140.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Frishman W.H. Management of hyperholesterinemia in older persons for the prevention of cardiovascular disease // Cardiol. Rev. — 2010. — Vol. 13, № 3. — Р. 132-140.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wong N.D., Wilson P.W., Kannel W.B. Serum cholesterol as a prognostic factor after myocardial infarction: the Framingham Study // Ann. Intern. Med. — 1991. — Vol. 115, № 9. — P. 687-693.</mixed-citation><mixed-citation xml:lang="en">Wong N.D., Wilson P.W., Kannel W.B. Serum cholesterol as a prognostic factor after myocardial infarction: the Framingham Study // Ann. Intern. Med. — 1991. — Vol. 115, № 9. — P. 687-693.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C. Risk factors for new coronary events in a large cohort of very elderly patients with and without coronary artery disease // Am. J. Cardiol. — 1996. — Vol. 77, № 10. — P. 864-866.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C. Risk factors for new coronary events in a large cohort of very elderly patients with and without coronary artery disease // Am. J. Cardiol. — 1996. — Vol. 77, № 10. — P. 864-866.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Castelli W.P., Wilson P.W., Levy D. et al. Cardiovascular risk factors in the elderly // Am. J. Cardiol. — 1989. — Vol. 63, № 16. — P. 12H-19H.</mixed-citation><mixed-citation xml:lang="en">Castelli W.P., Wilson P.W., Levy D. et al. Cardiovascular risk factors in the elderly // Am. J. Cardiol. — 1989. — Vol. 63, № 16. — P. 12H-19H.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lavie C.J., Milani R.V. National Cholesterol Education Program's recommen-dations, and implications of «missing» high-density lipoprotein cholesterol in cardiac rehabilitation programs // Am. J. Cardiol. — 1991. — Vol. 68, № 10. — P. 1087.</mixed-citation><mixed-citation xml:lang="en">Lavie C.J., Milani R.V. National Cholesterol Education Program's recommen-dations, and implications of «missing» high-density lipoprotein cholesterol in cardiac rehabilitation programs // Am. J. Cardiol. — 1991. — Vol. 68, № 10. — P. 1087.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Corti M.C., Guralnik J.M., Salive M.E. et al. HDL cholesterol predicts coronary heart disease mortality in older persons // J. Am. Med. Assoc. — 1995. — Vol. 274, № 7. — P. 539-544.</mixed-citation><mixed-citation xml:lang="en">Corti M.C., Guralnik J.M., Salive M.E. et al. HDL cholesterol predicts coronary heart disease mortality in older persons // J. Am. Med. Assoc. — 1995. — Vol. 274, № 7. — P. 539-544.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Corti M.C., Guralnik J.M., Salive M.E. et al. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons // Ann. Intern. Med. — 1997. — Vol. 126, № 10. — P. 753-760.</mixed-citation><mixed-citation xml:lang="en">Corti M.C., Guralnik J.M., Salive M.E. et al. Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons // Ann. Intern. Med. — 1997. — Vol. 126, № 10. — P. 753-760.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Reuben D.B., Ix J.H., Greendale G.A. et al. The predictive value of combined hypoalbuminemia and hypocholesterolemia in high functioning community-dwelling older persons: MacArthur studies of successful aging // J. Am. Geriatr. Soc. — 1999. — Vol. 47, № 4. — P. 402-406.</mixed-citation><mixed-citation xml:lang="en">Reuben D.B., Ix J.H., Greendale G.A. et al. The predictive value of combined hypoalbuminemia and hypocholesterolemia in high functioning community-dwelling older persons: MacArthur studies of successful aging // J. Am. Geriatr. Soc. — 1999. — Vol. 47, № 4. — P. 402-406.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ettinger W.H., Sun W.H., Brinkley N. et al. Interleukin-6 causes hypocholesterolemia in middle-aged and old rhesus monkeys // J. Gerontol. — 1995. — Vol. 50A. — P. M137-MI40.</mixed-citation><mixed-citation xml:lang="en">Ettinger W.H., Sun W.H., Brinkley N. et al. Interleukin-6 causes hypocholesterolemia in middle-aged and old rhesus monkeys // J. Gerontol. — 1995. — Vol. 50A. — P. M137-MI40.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf P.A. Cerebrovascular disease in the elderly / In: Tresch D.D., Aronow W.S., eds. // Cardiovascular disease in the elderly patient. — NY: Marcel Dekker, Inc, 1994. — P. 125-147.</mixed-citation><mixed-citation xml:lang="en">Wolf P.A. Cerebrovascular disease in the elderly / In: Tresch D.D., Aronow W.S., eds. // Cardiovascular disease in the elderly patient. — NY: Marcel Dekker, Inc, 1994. — P. 125-147.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C. Correlation of serum lipids with the presence or absence of atherothrombotic brain infarction and peripheral arterial disease in 1834 men and women aged 62 years // Am. J. Cardiol. — 1994. — Vol. 73, № 13. — P. 995-997.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C. Correlation of serum lipids with the presence or absence of atherothrombotic brain infarction and peripheral arterial disease in 1834 men and women aged 62 years // Am. J. Cardiol. — 1994. — Vol. 73, № 13. — P. 995-997.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Suryadevara V., Storey S.G., Aronow W.S. et al. Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascular disease // J. Gerontol. Med. Sci. — 2003. — Vol. 58A, № 9. — P. 859-861.</mixed-citation><mixed-citation xml:lang="en">Suryadevara V., Storey S.G., Aronow W.S. et al. Association of abnormal serum lipids in elderly persons with atherosclerotic vascular disease and dementia, atherosclerotic vascular disease without dementia, dementia without atherosclerotic vascular disease, and no dementia or atherosclerotic vascular disease // J. Gerontol. Med. Sci. — 2003. — Vol. 58A, № 9. — P. 859-861.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wannamethee S.G., Shaper G., Ebrahim S. HDL-cholesterol, total cholesterol, and the risk of stroke in middle-aged British men // Stroke. — 2000. — Vol. 31, № 8. — P. 1882-1888.</mixed-citation><mixed-citation xml:lang="en">Wannamethee S.G., Shaper G., Ebrahim S. HDL-cholesterol, total cholesterol, and the risk of stroke in middle-aged British men // Stroke. — 2000. — Vol. 31, № 8. — P. 1882-1888.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bassuk S.S., Wypij D., Berkman L.F. Cognitive impairment and mortality in the community-dwelling elderly // Am. J. Epidemiol. — 2000. — Vol. 151, № 7. — Р. 676-688.</mixed-citation><mixed-citation xml:lang="en">Bassuk S.S., Wypij D., Berkman L.F. Cognitive impairment and mortality in the community-dwelling elderly // Am. J. Epidemiol. — 2000. — Vol. 151, № 7. — Р. 676-688.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zimetbaum P., Frishman W.H., Ooi W.L. et al. Plasma lipids and lipoproteins and the incidence of cardiovascular disease in the very elderly: the Bronx Aging Study // Arterioscler. Thromb. — 1992. — Vol. 12, № 4. — P. 416-423.</mixed-citation><mixed-citation xml:lang="en">Zimetbaum P., Frishman W.H., Ooi W.L. et al. Plasma lipids and lipoproteins and the incidence of cardiovascular disease in the very elderly: the Bronx Aging Study // Arterioscler. Thromb. — 1992. — Vol. 12, № 4. — P. 416-423.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barsukov A., Bagaeva Z., Rezvantsev M., Shoustov S. Some metabolic patterns in essential hypertensive patients with different types of left ventricular hypertrophy // J. Hypertens. — 2009. — Vol. 2, Suppl. 4. — P. 90-91.</mixed-citation><mixed-citation xml:lang="en">Barsukov A., Bagaeva Z., Rezvantsev M., Shoustov S. Some metabolic patterns in essential hypertensive patients with different types of left ventricular hypertrophy // J. Hypertens. — 2009. — Vol. 2, Suppl. 4. — P. 90-91.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Барсуков А.В., Свеклина Т.С., Шустов С.Б. и др. Лабораторные маркеры кардиоваскулярного прогноза у пациентов с артериальной гипертензией в сочетании с сахарным диабетом и фибрилляцией предсердий // Вестн. Чуваш. гос. педагогич. ун-та. — 2010. — № 4. — С. 12-17. ЛЕКЦИ,</mixed-citation><mixed-citation xml:lang="en">Барсуков А.В., Свеклина Т.С., Шустов С.Б. и др. Лабораторные маркеры кардиоваскулярного прогноза у пациентов с артериальной гипертензией в сочетании с сахарным диабетом и фибрилляцией предсердий // Вестн. Чуваш. гос. педагогич. ун-та. — 2010. — № 4. — С. 12-17. ЛЕКЦИ,</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Соколова Л.А., Красильникова Е.И., Костромина Н.А. Метаболические изменения при гипертонической болезни // Артериальн. гипертенз. — 1997. — Т. 3, № 1, прил. — С. 54-55.</mixed-citation><mixed-citation xml:lang="en">Соколова Л.А., Красильникова Е.И., Костромина Н.А. Метаболические изменения при гипертонической болезни // Артериальн. гипертенз. — 1997. — Т. 3, № 1, прил. — С. 54-55.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Конради А.О., Полуничева Е.В. Недостаточная приверженность к лечению артериальной гипертензии: причины и пути коррекции // Артериальн. гипертенз. — 2004. — Т. 10, № 3. — С. 137-142.</mixed-citation><mixed-citation xml:lang="en">Конради А.О., Полуничева Е.В. Недостаточная приверженность к лечению артериальной гипертензии: причины и пути коррекции // Артериальн. гипертенз. — 2004. — Т. 10, № 3. — С. 137-142.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ades P.A., Poehlman E.T. The effect of exercise training on serum lipids in the elderly // Am. J. Geriatr. Cardiol. — 1996. — Vol. 5, № 5. — P. 27-34.</mixed-citation><mixed-citation xml:lang="en">Ades P.A., Poehlman E.T. The effect of exercise training on serum lipids in the elderly // Am. J. Geriatr. Cardiol. — 1996. — Vol. 5, № 5. — P. 27-34.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) // Lancet. — 1994. — Vol. 344, № 8934. — P. 1383-1389.</mixed-citation><mixed-citation xml:lang="en">Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) // Lancet. — 1994. — Vol. 344, № 8934. — P. 1383-1389.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen T.R., Wilhelmsen L., Faergeman O. et al. Follow-up study of patients randomized in the Scandinavian Simvastatin Survival Study (4S) // Am. J. Cardiol. — 2000. — Vol. 86, № 3. — P. 257-262.</mixed-citation><mixed-citation xml:lang="en">Pedersen T.R., Wilhelmsen L., Faergeman O. et al. Follow-up study of patients randomized in the Scandinavian Simvastatin Survival Study (4S) // Am. J. Cardiol. — 2000. — Vol. 86, № 3. — P. 257-262.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis S.J., Sacks F.M., Mitchell J.S. et al. Effect of pravastatin on cardiovascular events in women after myocardial infarction // J. Am. Coll. Cardiol. — 1998. — Vol. 32, № 1. — P. 140-146.</mixed-citation><mixed-citation xml:lang="en">Lewis S.J., Sacks F.M., Mitchell J.S. et al. Effect of pravastatin on cardiovascular events in women after myocardial infarction // J. Am. Coll. Cardiol. — 1998. — Vol. 32, № 1. — P. 140-146.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Plehn J.F., Davis B.R., Sacks F.M. et al. Reduction of stroke incidence after myocardial infarction with pravastatin: the cholesterol and recurrent events (CARE) study // Circulation. — 1999. — Vol. 99, № 2. — P. 216-223.</mixed-citation><mixed-citation xml:lang="en">Plehn J.F., Davis B.R., Sacks F.M. et al. Reduction of stroke incidence after myocardial infarction with pravastatin: the cholesterol and recurrent events (CARE) study // Circulation. — 1999. — Vol. 99, № 2. — P. 216-223.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">The LIPID Study Group. Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: the LIPID trial follow-up // Lancet. — 2002. — Vol. 359, № 9315. — P. 1379-1387.</mixed-citation><mixed-citation xml:lang="en">The LIPID Study Group. Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: the LIPID trial follow-up // Lancet. — 2002. — Vol. 359, № 9315. — P. 1379-1387.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial // Lancet. — 2002. — Vol. 360, № 9326. — P. 7-22.</mixed-citation><mixed-citation xml:lang="en">Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial // Lancet. — 2002. — Vol. 360, № 9326. — P. 7-22.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Shepherd J., Blauw G.J., Murphy M.B. et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial // Lancet. — 2002. — Vol. 360, № 9346. — P. 1623-1630.</mixed-citation><mixed-citation xml:lang="en">Shepherd J., Blauw G.J., Murphy M.B. et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial // Lancet. — 2002. — Vol. 360, № 9346. — P. 1623-1630.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz G.G., Olsson A.G., Ezekowitz M.D. et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial // J. Am. Med. Assoc. — 2001. — Vol. 285, № 13. — P. 1711-1718.</mixed-citation><mixed-citation xml:lang="en">Schwartz G.G., Olsson A.G., Ezekowitz M.D. et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial // J. Am. Med. Assoc. — 2001. — Vol. 285, № 13. — P. 1711-1718.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">de Lemos J.A., Blazing M.A., Wiviott S.D. et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes phase Z of the A to Z trial // J. Am. Med. Assoc. — 2004. — Vol. 292, № 11. — P. 1307-1316.</mixed-citation><mixed-citation xml:lang="en">de Lemos J.A., Blazing M.A., Wiviott S.D. et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes phase Z of the A to Z trial // J. Am. Med. Assoc. — 2004. — Vol. 292, № 11. — P. 1307-1316.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Cholesterol treatment trialists' (CTT) eollaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomized trials of statins // Lancet. — 2005. — Vol. 366, № 9493. — P. 1267-1278.</mixed-citation><mixed-citation xml:lang="en">Cholesterol treatment trialists' (CTT) eollaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomized trials of statins // Lancet. — 2005. — Vol. 366, № 9493. — P. 1267-1278.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Deedwania P., Stone P.H., Merz C.N. et al. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE) // Circulation. — 2007. — Vol. 115, № 6. — P. 700-707.</mixed-citation><mixed-citation xml:lang="en">Deedwania P., Stone P.H., Merz C.N. et al. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE) // Circulation. — 2007. — Vol. 115, № 6. — P. 700-707.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Chaturvedi S., Zivin J., Breazna A. et al; for the SPARCL investigators. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack // Neurology. — 2009. — Vol. 72, № 8. — P. 688-694.</mixed-citation><mixed-citation xml:lang="en">Chaturvedi S., Zivin J., Breazna A. et al; for the SPARCL investigators. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack // Neurology. — 2009. — Vol. 72, № 8. — P. 688-694.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein L.B., Amarenco P., Szarek M. et al. on behalf of the SPARCL investigators. Hemorrhagic stroke in the Stroke prevention by aggressive reduction in cholesterol levels study // Neurology. — 2008. — Vol. 70, № 24, Pt. 2. — P. 2364-2370.</mixed-citation><mixed-citation xml:lang="en">Goldstein L.B., Amarenco P., Szarek M. et al. on behalf of the SPARCL investigators. Hemorrhagic stroke in the Stroke prevention by aggressive reduction in cholesterol levels study // Neurology. — 2008. — Vol. 70, № 24, Pt. 2. — P. 2364-2370.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sacco R.L., Chong J.Y., Prabhakaran S., Elkind M.S. Experimental treatments for acute ischemic stroke // Lancet. — 2007. — Vol. 369, № 9558. — P. 331-341.</mixed-citation><mixed-citation xml:lang="en">Sacco R.L., Chong J.Y., Prabhakaran S., Elkind M.S. Experimental treatments for acute ischemic stroke // Lancet. — 2007. — Vol. 369, № 9558. — P. 331-341.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Szczepanska-Szerej A., Kurzepa J., Wojczal J., Stelmasiak Z. Simvastatin-induced prevention of the increase in TNF-alpha level in the acute phase of ischemic stroke // Pharmacol. Rep. — 2007. — Vol. 59, № 1. — Р. 94-97.</mixed-citation><mixed-citation xml:lang="en">Szczepanska-Szerej A., Kurzepa J., Wojczal J., Stelmasiak Z. Simvastatin-induced prevention of the increase in TNF-alpha level in the acute phase of ischemic stroke // Pharmacol. Rep. — 2007. — Vol. 59, № 1. — Р. 94-97.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ridker P.M., Danielson E., Francisco M.I. et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein // N. Engl. J. Med. — 2008. — Vol. 359, № 21. — P. 2195-2207.</mixed-citation><mixed-citation xml:lang="en">Ridker P.M., Danielson E., Francisco M.I. et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein // N. Engl. J. Med. — 2008. — Vol. 359, № 21. — P. 2195-2207.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C. Incidence of new coronary events in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // Am. J. Cardiol. — 2002. — Vol. 89, № 1. — Р. 67-69.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C. Incidence of new coronary events in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // Am. J. Cardiol. — 2002. — Vol. 89, № 1. — Р. 67-69.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C., Gutstein H. Incidence of new atherothrombotic brain infarction in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // J. Gerontol. Med. Sci. — 2002. — Vol. 57A, № 5. — P. M333-M335.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C., Gutstein H. Incidence of new atherothrombotic brain infarction in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // J. Gerontol. Med. Sci. — 2002. — Vol. 57A, № 5. — P. M333-M335.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C. Frequency of congestive heart failure in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // Am. J. Cardiol. — 2002. — Vol. 90, № 2. — P. 147-149.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C. Frequency of congestive heart failure in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol &gt; or = 125 mg/dL treated with statins versus no lipid-lowering drug // Am. J. Cardiol. — 2002. — Vol. 90, № 2. — P. 147-149.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Aronow W.S., Ahn C. Reduction of coronary events with aspirin in older patients with prior myocardial infarction treated with and without statins // Heart Dis. — 2002. — Vol. 4, № 3. — P. 159-161.</mixed-citation><mixed-citation xml:lang="en">Aronow W.S., Ahn C. Reduction of coronary events with aspirin in older patients with prior myocardial infarction treated with and without statins // Heart Dis. — 2002. — Vol. 4, № 3. — P. 159-161.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen T.R., Faergeman O., Kastelein J.J. et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial // J. Am. Med. Assoc. — 2005. — Vol. 294, № 19. — P. 2437-2445.</mixed-citation><mixed-citation xml:lang="en">Pedersen T.R., Faergeman O., Kastelein J.J. et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial // J. Am. Med. Assoc. — 2005. — Vol. 294, № 19. — P. 2437-2445.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Ravipati G., Aronow W.S., Ahn C. et al. Incidence of new stroke or new myocardial infarction or death in patients with severe carotid arterial disease treated with and without statins // Am. J. Cardiol. — 2006. — Vol. 98, № 9. — P. 1170-1171.</mixed-citation><mixed-citation xml:lang="en">Ravipati G., Aronow W.S., Ahn C. et al. Incidence of new stroke or new myocardial infarction or death in patients with severe carotid arterial disease treated with and without statins // Am. J. Cardiol. — 2006. — Vol. 98, № 9. — P. 1170-1171.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sukhija R., Aronow W.S., Sandhu R., Kakar P., Babu S. Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins // Am. J. Cardiol. — 2006. — Vol. 97, № 2. — P. 279-280.</mixed-citation><mixed-citation xml:lang="en">Sukhija R., Aronow W.S., Sandhu R., Kakar P., Babu S. Mortality and size of abdominal aortic aneurysm at long-term follow-up of patients not treated surgically and treated with and without statins // Am. J. Cardiol. — 2006. — Vol. 97, № 2. — P. 279-280.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Afilalo J., Duque G., Steele R. et al. Statins for secondary prevention in elderly patients // J. Am. Coll. Cardiol. — 2008. — Vol. 51, № 1. — Р. 37-45.</mixed-citation><mixed-citation xml:lang="en">Afilalo J., Duque G., Steele R. et al. Statins for secondary prevention in elderly patients // J. Am. Coll. Cardiol. — 2008. — Vol. 51, № 1. — Р. 37-45.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sukhija R., Bursac Z., Kakar P. et al. Effect of statins on the development of renal dysfunction // Am. J. Cardiol. — 2008. — Vol. 101, № 7. — P. 975-979.</mixed-citation><mixed-citation xml:lang="en">Sukhija R., Bursac Z., Kakar P. et al. Effect of statins on the development of renal dysfunction // Am. J. Cardiol. — 2008. — Vol. 101, № 7. — P. 975-979.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Foody J.M., Shah R., Galusha D. et al. Statins and mortality among elderly patients hospitalized with heart failure // Circulation. — 2006. — Vol. 113, № 8. — P. 1086-1092.</mixed-citation><mixed-citation xml:lang="en">Foody J.M., Shah R., Galusha D. et al. Statins and mortality among elderly patients hospitalized with heart failure // Circulation. — 2006. — Vol. 113, № 8. — P. 1086-1092.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">GISSI-HF Investigators. Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial // Lancet. — 2008. — Vol. 372, № 9645. — P. 1231-1239.</mixed-citation><mixed-citation xml:lang="en">GISSI-HF Investigators. Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial // Lancet. — 2008. — Vol. 372, № 9645. — P. 1231-1239.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Desai H., Aronow W.S., Ahn C. et al. Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with heart failure treated with combined cardiac resynchronization plus implantable cardioverter-defibrillator therapy versus implantable cardioverter- defibrillator therapy // J. Cardiovasc. Pharmacol. Ther. — 2010. — Vol. 15, № 1. — Р. 37-40.</mixed-citation><mixed-citation xml:lang="en">Desai H., Aronow W.S., Ahn C. et al. Incidence of appropriate cardioverter-defibrillator shocks and mortality in patients with heart failure treated with combined cardiac resynchronization plus implantable cardioverter-defibrillator therapy versus implantable cardioverter- defibrillator therapy // J. Cardiovasc. Pharmacol. Ther. — 2010. — Vol. 15, № 1. — Р. 37-40.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Q.L., Koenig W., Raum E. et al. Epidemiology of chronic kidney disease: results from a population of older adults in Germany // Prev. Med. — 2009. — Vol. 48, № 2. — Р. 122-127.</mixed-citation><mixed-citation xml:lang="en">Zhang Q.L., Koenig W., Raum E. et al. Epidemiology of chronic kidney disease: results from a population of older adults in Germany // Prev. Med. — 2009. — Vol. 48, № 2. — Р. 122-127.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Zolkiewicz M., Sucajtys E., Chmielewski M. et al. Increased rate of cholesterologenesis — a possible cause of hypercholesterolemia in experimental chronic renal failure in rats // Horm. Metab. Res. — 2002. — Vol. 34, № 5. — P. 234-237.</mixed-citation><mixed-citation xml:lang="en">Zolkiewicz M., Sucajtys E., Chmielewski M. et al. Increased rate of cholesterologenesis — a possible cause of hypercholesterolemia in experimental chronic renal failure in rats // Horm. Metab. Res. — 2002. — Vol. 34, № 5. — P. 234-237.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Baigent C., Landry M. Study of heart and renal protection (SHARP) // Kidney Int. — 2003. — Vol. 63. — P. S207-S210.</mixed-citation><mixed-citation xml:lang="en">Baigent C., Landry M. Study of heart and renal protection (SHARP) // Kidney Int. — 2003. — Vol. 63. — P. S207-S210.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Baigent C., Landray M.J., Reith C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomized placebo-controlled trial // Lancet. — 2011. DOI: 10.1016/SO140- 6736(11)60739-3.</mixed-citation><mixed-citation xml:lang="en">Baigent C., Landray M.J., Reith C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomized placebo-controlled trial // Lancet. — 2011. DOI: 10.1016/SO140- 6736(11)60739-3.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Jick H., Zomberg G.L., Jick S.S. et al. Statins and the risk of dementia // Lancet. — 2000. — Vol. 356, № 9242. — P. 1627-1631.</mixed-citation><mixed-citation xml:lang="en">Jick H., Zomberg G.L., Jick S.S. et al. Statins and the risk of dementia // Lancet. — 2000. — Vol. 356, № 9242. — P. 1627-1631.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Rockwood K., Kirkland S., Hogan D.B. et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people // Arch. Neurol. — 2002. — Vol. 59, № 2. — P. 223-227.</mixed-citation><mixed-citation xml:lang="en">Rockwood K., Kirkland S., Hogan D.B. et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people // Arch. Neurol. — 2002. — Vol. 59, № 2. — P. 223-227.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">King D.S., Jones D.W., Wofford M.R. et al. Cognitive impairment associated with atorvastatin // Presented at the American Allege of Clinical Pharmacy Spring Practice and Research Forum. — Salt Lake City, 2001, April 22-25.</mixed-citation><mixed-citation xml:lang="en">King D.S., Jones D.W., Wofford M.R. et al. Cognitive impairment associated with atorvastatin // Presented at the American Allege of Clinical Pharmacy Spring Practice and Research Forum. — Salt Lake City, 2001, April 22-25.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">King D.S., Wilburn A.J., Wofford M.R. et al. Cognitive impairment associated with atorvastatin and simvastatin // Pharmacotherapy. — 2003. — Vol. 23, № 12. — Р. 1663-1667.</mixed-citation><mixed-citation xml:lang="en">King D.S., Wilburn A.J., Wofford M.R. et al. Cognitive impairment associated with atorvastatin and simvastatin // Pharmacotherapy. — 2003. — Vol. 23, № 12. — Р. 1663-1667.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Orsi A., Sherman O., Woldeselassie Z. Simvastatin-associated memory loss // Pharmacotherapy. — 2001. — Vol. 21, № 6. — Р. 767769.</mixed-citation><mixed-citation xml:lang="en">Orsi A., Sherman O., Woldeselassie Z. Simvastatin-associated memory loss // Pharmacotherapy. — 2001. — Vol. 21, № 6. — Р. 767769.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Wagstaff L.R., Mitton M.W., Arvik B.M., Doraiswamy P.M. Statin-associated memory loss: analysis of 60 case reports and review of the literature // Pharmacotherapy. — 2003. — Vol. 23, № 7. — Р. 871-880. лЕкция Том 17, № 5 / 2011</mixed-citation><mixed-citation xml:lang="en">Wagstaff L.R., Mitton M.W., Arvik B.M., Doraiswamy P.M. Statin-associated memory loss: analysis of 60 case reports and review of the literature // Pharmacotherapy. — 2003. — Vol. 23, № 7. — Р. 871-880. лЕкция Том 17, № 5 / 2011</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Trompet S., van Vliet P., de Craen A.J. et al. Pravastatin and cognitive function in the elderly: results of the PROSPER study // J. Neurol. — Vol. 257, № 1. — Р. 85-90.</mixed-citation><mixed-citation xml:lang="en">Trompet S., van Vliet P., de Craen A.J. et al. Pravastatin and cognitive function in the elderly: results of the PROSPER study // J. Neurol. — Vol. 257, № 1. — Р. 85-90.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Dale K.M., Coleman C.I., Henyan N.N. et al. Statins and cancer risk: a meta-analysis // J. Am. Med. Assoc. — 2006. — Vol. 295, № 1. — Р. 74-80.</mixed-citation><mixed-citation xml:lang="en">Dale K.M., Coleman C.I., Henyan N.N. et al. Statins and cancer risk: a meta-analysis // J. Am. Med. Assoc. — 2006. — Vol. 295, № 1. — Р. 74-80.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Gransbo K., Melander O., Wallentin L. et al. Cardiovascular and cancer mortality in very elderly post-infarction patients receiving statin treatment // J. Am. Coll. Cardiol. — 2010. — Vol. 55. № 13. — P. 1362-1369.</mixed-citation><mixed-citation xml:lang="en">Gransbo K., Melander O., Wallentin L. et al. Cardiovascular and cancer mortality in very elderly post-infarction patients receiving statin treatment // J. Am. Coll. Cardiol. — 2010. — Vol. 55. № 13. — P. 1362-1369.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment: Panel III) // J. Am. Med. Assoc. — 2001. — Vol. 285, № 19. — P. 2486-2497.</mixed-citation><mixed-citation xml:lang="en">Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment: Panel III) // J. Am. Med. Assoc. — 2001. — Vol. 285, № 19. — P. 2486-2497.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Grundy S.M., Cleeman J.I., Merz C.N. et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines // Circulation. — 2004. — Vol. 1, № 10. — Р. 227-239.</mixed-citation><mixed-citation xml:lang="en">Grundy S.M., Cleeman J.I., Merz C.N. et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines // Circulation. — 2004. — Vol. 1, № 10. — Р. 227-239.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Warshafsky S., Packard D., Marks S.J. et al. Efficacy of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for prevention of stroke // J. Gen. Intern. Med. — 1999. — Vol. 14, № 12. — P. 763-774.</mixed-citation><mixed-citation xml:lang="en">Warshafsky S., Packard D., Marks S.J. et al. Efficacy of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for prevention of stroke // J. Gen. Intern. Med. — 1999. — Vol. 14, № 12. — P. 763-774.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Vergouwen M.D., de Haan R.J., Vermeulen M., Roos Y.B. Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovas-cular disease // Stroke. — 2008. — Vol. 39, № 2. — P. 497-502.</mixed-citation><mixed-citation xml:lang="en">Vergouwen M.D., de Haan R.J., Vermeulen M., Roos Y.B. Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovas-cular disease // Stroke. — 2008. — Vol. 39, № 2. — P. 497-502.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
