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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2015-21-1-16-26</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-169</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ДЕТСКАЯ ЭНДОКРИНОЛОГИЯ — НАУЧНЫЕ ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ РАЗВИТИЯ</article-title><trans-title-group xml:lang="en"><trans-title>PEDIATRIC ENDOCRINOLOGY — SCIENTIFIC ACHIEVEMENTS AND FUTURE DIRECTIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Ирина Леоровна — доктор медицинских наук, заведующая научно-исследовательской лабораторией детской эндокринологии института эндокринологии, профессор кафедры внутренних болезней ФГБУ «СЗФМИЦ» Минздрава России; главный внештатный педиатр Минздрава РФ по СЗФО.</p></bio><bio xml:lang="en"><p>Irina L. Nikitina, MD, PhD, Professor, Department of Internal Diseases, Federal North-West Medical Research Centre, Head, Research Laboratory of Children’s Endocrinology, Institution of Endocrinology, Federal NorthWest Medical Research Centre; main visiting pediatrician of Ministry of Health Care System of North-West Federal Region.</p><p> </p></bio><email xlink:type="simple">nikitina0901@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Западный федеральный медицинский исследовательский центр, Санкт-Петербург</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal North-West Medical Research Centre, St Petersburg</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>29</day><month>04</month><year>2015</year></pub-date><volume>21</volume><issue>1</issue><fpage>16</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитина И.Л., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Никитина И.Л.</copyright-holder><copyright-holder xml:lang="en">Nikitina I.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/169">https://htn.almazovcentre.ru/jour/article/view/169</self-uri><abstract><p>В публикации представлен обзор результатов наиболее важных научных исследований в области детской эндокринологии, проводимых в мире в последние годы. Приведены современные сведения о молекулярно-генетических, клеточных и протеомных механизмах болезней эндокринных органов у детей, обсуждены персонифицированные подходы к их диагностике и терапии. Проанализирован мировой опыт лечения низкорослости, нарушений формирования пола, болезни Кушинга и других эндокринных расстройств. Обозначены перспективные направления развития детской эндокринологии.</p></abstract><trans-abstract xml:lang="en"><p>Review of the most important scientific investigations in the field of pediatric endocrinology performing in the world is presented in the article. Modern data of molecular genetic, proteomic mechanisms of endocrine diseases in children and adolescents are discussed, along with the individual approaches of their diagnostics and treatment. Wide world experience of medical care of hypopituitarism, disorders of sex development, Cushing's disease and other endocrine disorders was analyzed and summarized in the paper. The prospective directions of development of pediatric endocrinology are considered and outlined.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>детская эндокринология</kwd><kwd>дети</kwd><kwd>подростки</kwd><kwd>диабет</kwd><kwd>низкорослость</kwd><kwd>нарушение формирования пола</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pediatric endocrinology</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>diabetes</kwd><kwd>short stature</kwd><kwd>disorder of sex development</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Berchold LA, Storling ZM, Ortis F, Lage K, BangBerthelsen C, Bergholdt R et al. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and b-cell apoptosis. 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