References

arthyper

Артериальная гипертензия

"Arterial’naya Gipertenziya" ("Arterial Hypertension")

1607-419X2411-8524

Antihypertensive League

10.18705/1607-419X-2012-18-3-184-190

arthyper-1697

Research Article

СТРАНИЦА СОМНОЛОГА

SOMNOLOGIST’S PAGE

Механизмы развития резистентности к антигипертензивной терапии при синдроме обструктивного апноэ во время сна

Possible mechanisms of drug-resistance in hypertensive patients with obstructive sleep apnea

Звартау

Н. Э.

Zvartau

N. E.

nzvart@yahoo.com

Свиряев

Ю. В.

Sviryaev

YU. V.

noemail@neicon.ru

Коростовцева

Л. С.

Korostovtseva

L. S.

noemail@neicon.ru

Конради

А. О.

Konradi

A. O.

noemail@neicon.ru

ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФРоссияAlmazov Federal Heart, Blood and Endocrinology CentreRussian Federation

2012

28062012

183184190

2012

Звартау Н.Э., Свиряев Ю.В., Коростовцева Л.С., Конради А.О.

Zvartau N.E., Sviryaev Y.V., Korostovtseva L.S., Konradi A.O.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://htn.almazovcentre.ru/jour/article/view/1697

В обзоре обсуждаются возможные механизмы, лежащие в основе формирования резистентности к антигипертензивной терапии у больных с синдромом обструктивного апноэ во время сна (СОАС) и артериальной гипертензией (АГ). Приводятся данные о более выраженном поражении органов-мишеней, которое можно частично объяснить активацией воспалительных процессов, эндотелиальной дисфункцией вследствие повторных эпизодов гипоксии, а также особенностями АГ у пациентов с СОАС. Активация ренин-ангиотензин-альдостероновой системы с повышением уровня альдостерона, помимо отрицательного влияния на сердечно-сосудистую систему, усугубляет течение самого СОАС.

The article reviews possible mechanisms responsible for drug resistance in hypertensive patients with obstructive sleep apnea. Data about more profound target organ damage, partly explained by activation of inflammation, endothelial dysfunction due to recurrent hypoxia episodes and by blood pressure pattern in apnea patients are presented. Stimulation of renin-angiotensin-aldosterone system has a negative impact on cardiovascular system and deteriorates sleep apnea severity.

синдром обструктивного апноэ во время снарезистентная артериальная гипертензияожирениевоспалениепоражение органов-мишенейальдостерон

obstructive sleep apnea syndromeresistant hypertensionobesityinflammationtarget organ damagealdosterone

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The authors declare that there are no conflicts of interest present.