arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2012-18-5-421-428arthyper-1725Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLEПолиморфизм гена Apo E у пациентов с метаболическим синдромом и когнитивными расстройствамиApo E gene polymorphism in patients with metabolic syndrome and cognitive disordersЗуеваИ. Б.ZuevaI. B.iravit@yandex.ruУлитинаА. С.UlitinaA. S.noemail@neicon.ruГорабД. Н.GhorabD. N.noemail@neicon.ruМоскаленкоМ. В.MoskalenkoM. V.noemail@neicon.ruДубинаМ. В.DubinaM. V.noemail@neicon.ruФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФРоссияAlmazov Federal Heart, Blood and Endocrinology CentreRussian FederationФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ; ГБОУ ВПО «Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздравсоцразвития РФРоссияAlmazov Federal Heart, Blood and Endocrinology Centre; I.P. Pavlov St Petersburg State Medical UniversityRussian FederationГБОУ ВПО «Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздравсоцразвития РФ; Санкт-Петербургский академический университет, научно-образовательный центр нанотехнологий Российской академии наукРоссияI.P. Pavlov St Petersburg State Medical University; St Petersburg State Academic University, Nanotechnology Research and Education Centre of Russian Academy of SciencesRussian FederationФГОУ ВПО «Санкт-Петербургский государственный университет»РоссияSt Petersburg State UniversityRussian Federation201228102012185421428Copyright © Зуева И.Б., Улитина А.С., Гораб Д.Н., Москаленко М.В., Дубина М.В., 20122012Зуева И.Б., Улитина А.С., Гораб Д.Н., Москаленко М.В., Дубина М.В.Zueva I.B., Ulitina A.S., Ghorab D.N., Moskalenko M.V., Dubina M.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1725

Цель исследования — определение частот аллельных вариантов, обусловленных полиморфизмом гена Apo E у лиц с метаболическим синдром (МС) и когнитивными нарушениями (КН). Материалы и методы. Обследованы 54 человека с использованием антропометрии, биохимического анализа крови (глюкоза, липидный спектр), молекулярно-генетического анализа (полимеразная цепная реакция, полиморфизм длин рестрикционных фрагментов) и нейропсихологических тестов. Выводы. Аллельный вариант s4 гена Apo E является неблагоприятным фактором, способствующим развитию КН, депрессии, тревожных расстройств. Носительство аллеля s2 является протективным фактором в отношении развития депрессии.

Objective. Тс determine allelic variants frequencies caused by Apo E polymorphism in patients with metabolic syndrome and cognitive dysfunction (CD). Design and methods. 54 participants had undergone anthropometric measurements, blood examination (glucose, cholesterol and triglycerides), molecular genetic analysis (polymerase chain reaction, restriction fragments length polymorphism) and neuropsychological tests. Results. Allelic variant s4 of Apo E is an unfavourable factor contributing to the development of CD, depression, anxiety disorders. Allelic variant s2 of Apo E is protective factor in relation to the development of depression.

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The authors declare that there are no conflicts of interest present.