arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2015-21-1-48-58arthyper-173Research ArticleОБЗОРREVIEWВИТАМИН D, ОЖИРЕНИЕ И РИСК КАРДИОРЕНАЛЬНЫХ НАРУШЕНИЙ У ДЕТЕЙVITAMIN D, OBESITY AND CARDIORENAL RISK IN CHILDRENКуприенкоН. Б.KuprienkoN. B.

Natalya B. Kupriyenko, MD, PhD, Associate Professor, Junior Researcher, Research Laboratory of Diagnostics and Treatment of Pediatrics Pathology, Institute of Perinatology and Pediatrics, Federal North-West Medical Research Centre, Associate Professor of Pediatrics, Pediatrics Department, First Pavlov State Medical University of St. Petersburg

n-b-k@bk.ruСмирноваН. Н.SmirnovaN. N.

Natalia N. Smirnova, MD, PhD, Professor, Senior Researcher, Research Laboratory of Diagnostics and Treatment of Pediatrics Pathology, Institute of Perinatology and Pediatrics, Federal North-West Medical Research Centre, Head, Pediatrics Department, First Pavlov State Medical University of St. Petersburg

n-b-k@bk.ruСеверо-Западный федеральный медицинский исследовательский центр, Санкт-Петербург Первый Санкт- Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияFederal North-West Medical Research Centre, St Petersburg First Pavlov State Medical University of St. Petersburg, St PetersburgRussian Federation2015290420152114858Copyright © Куприенко Н.Б., Смирнова Н.Н., 20152015Куприенко Н.Б., Смирнова Н.Н.Kuprienko N.B., Smirnova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/173

В обзоре рассмотрены некоторые механизмы плейотропного действия витамина D, значимости уровня 25 (ОН)D в плазме как индикатора обеспеченности организма витамином, вопрос о токсичности витамина D. Отражены современные представления о строении и функциях витамин D-рецептора, регуляции экспрессии витамин D-зависимых генов. Обсуждается адипогенная активность витамина D, роль его метаболитов, витамин D-связывающего протеина, фактора роста фибробластов-23 в регуляции жирового, углеводного и энергетического обмена. Приводятся данные экспериментальных и клинических исследований влияния дефицита витамина D на развитие инсулинорезистентности, сердечно-сосудистых заболеваний и патологии почек. Показаны перспективы клинического применения витамина D в ренопротекции, влияния на ренин-ангиотензиновую систему, модификации эффектов гена, ассоциированного с ожирением (FTO) у детей. Требуются дальнейшие исследования для выработки практических рекомендаций по применению витамина D при ожирении и метаболическом синдроме у детей.

The article reviews some pleiotropic effects of vitamin D, shows that plasma level of 25 (OH)D is an indicator of organism supplement with vitamin D. Also some issues of vitamin D toxicity are discussed. Novel ideas about structure and functions of vitamin D-receptor, regulation of vitamin D-dependent genes expression are presented. Adipogenic activity of vitamin D, the role of its metabolites, vitamin D-connecting protein, fibroblast growth factor-23 inregulation of lipid, carbohydrate and energy metabolism are discussed. The paper summarizes the data from pilot and clinical studies of vitamin D deficiency and its influence on the development of insulin resistance, cardiovascular and kidney diseases. Possible ways of clinical use of vitamin D as a renoprotector and modulator of renin-angiotensin system are shown, along with the modulating effects of gene cluster associated with obesity (FTO) in children. Further investigations aimed at the practical recommendations development regarding the use of vitamin D in obesity and a metabolic syndrome in children are anticipated.

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The authors declare that there are no conflicts of interest present.