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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2015-21-1-59-68</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-174</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>ОСОБЕННОСТИ ЦЕНТРАЛЬНОГО АОРТАЛЬНОГО ДАВЛЕНИЯ И ИНДЕКСА АУГМЕНТАЦИИ У ЛИЦ МОЛОДОГО ВОЗРАСТА С УЧЕТОМ ФАКТОРОВ СЕРДЕЧНО-СОСУДИСТОГО РИСКА</article-title><trans-title-group xml:lang="en"><trans-title>СENTRAL AORTIC PRESSURE AND AUGMENTATION INDEX IN YOUNG ADULTS WITH REGARD TO CARDIOVASCULAR RISK FACTORS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евсевьева</surname><given-names>М. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Evsevyeva</surname><given-names>M. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евсевьева Мария Евгеньевна — доктор медицинских наук, профессор, заведующая кафедрой факультетской терапии «СтГМУ», руководитель центра студенческого здоровья «СтГМУ», заслуженный врач РФ, член правления РКО</p></bio><bio xml:lang="en"><p>Maria E. Evsevyeva, MD, PhD, Professor, Honoured Physician of the Russian Federation, Board Member, Russian Society of Cardiology, Head, Department of Internal Medicine, Head, Student Health Center, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеева Оксана Владимировна — кандидат медицинских наук, доцент кафедры факультетской терапии «СтГМУ»</p></bio><bio xml:lang="en"><p>Oksana V. Sergeeva, MD, PhD, Assistant Professor, Department of Internal Diseases, Physician, Student Health Center, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добросельский</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobroselskiy</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Добросельский Владимир Николаевич — клинический ординатор кафедры факультетской терапии «СтГМУ»</p></bio><bio xml:lang="en"><p>Vladimir N. Dobroselskiy, MD, Postgraduate student, Department of Internal Diseases, Student Health Center, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Еремин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Eremin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ерeмин Михаил Владимирович — кандидат медицинских наук, врач ГБУЗ СК «Ставропольская краевая клиническая больница»</p></bio><bio xml:lang="en"><p>Mikhail V. Eremin, MD, PhD, Physician, Regional Clinical Hospital of Stavropol region University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ростовцева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rostovtseva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовцева Мария Владимировна — заочный аспирант кафедры факультетской терапии «СтГМУ»</p></bio><bio xml:lang="en"><p>Maria V. Rostovtseva, MD, Postgraduate Student, Department of Internal Diseases, Student Health Center, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галькова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Galkova</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галькова Илона Юрьевна — очный аспирант кафедры факультетской терапии СтГМУ»</p></bio><bio xml:lang="en"><p>Ilona Y. Galkova, MD, , Assistant, Department of Internal Diseases, Physician, Student Health Center, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнова Татьяна Александровна — очный аспирант кафедры факультетской терапии «СтГМУ»</p></bio><bio xml:lang="en"><p>Tatiana A. Smirnova, MD, Assistant, Department of Internal Diseases, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвинова Мария Васильевна — очный аспирант кафедры факультетской терапии «СтГМУ»</p></bio><bio xml:lang="en"><p>Maria V. Litvinova, MD, Postgraduate Student, Department of Internal Diseases, Stavropol State Medical University</p></bio><email xlink:type="simple">evsevieva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ставропольский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Stavropol State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>29</day><month>04</month><year>2015</year></pub-date><volume>21</volume><issue>1</issue><fpage>59</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Евсевьева М.Е., Сергеева О.В., Добросельский В.Н., Еремин М.В., Ростовцева М.В., Галькова И.Ю., Смирнова Т.А., Литвинова М.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Евсевьева М.Е., Сергеева О.В., Добросельский В.Н., Еремин М.В., Ростовцева М.В., Галькова И.Ю., Смирнова Т.А., Литвинова М.В.</copyright-holder><copyright-holder xml:lang="en">Evsevyeva M.E., Sergeeva O.V., Dobroselskiy V.n., Eremin M.V., Rostovtseva M.V., Galkova I.Y., Smirnova T.A., Litvinova M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/174">https://htn.almazovcentre.ru/jour/article/view/174</self-uri><abstract><p>Цель исследования — оценить центральное аортальное артериальное давление (АД) и индекс его аугментации у лиц молодого возраста с учетом наличия факторов риска (ФР) в процессе проведения внутривузовской диспансеризации.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Обследованы 78 студентов 3–4 курсов в возрасте от 19 до 23 лет в рамках диспансерного обследования на базе центра студенческого здоровья СтГМУ в рамках проекта «Вуз — территория здоровья». Кроме скрининга факторов риска, изучали параметры центрального аортального давления осциллометрическим методом с помощью диагностического комплекса BPLab (Компания ООО «Петр Телегин», Новосибирск, Россия) по технологии Vasotens Office. Кроме традиционных параметров АД плечевой артерии, анализировались также систолическое АД аортальное (SYSao/САДao), диастолическое АД аортальное (DIAao/ДАДao), пульсовое АД аортальное (PPao/ПАДao), среднее АД аортальное (MBPao/СрДao), длительность периода изгнания левого желудочка (ED), индекс аугментации в аорте (AIxao), амплификация пульсового давления (PPA) и индекс эффективности субэндокардиального кровотока (SEVR). Обследованных распределили по двум группам наблюдения: 1 группа — без ФР (контрольная группа); 2 группа — с наличием ФР (основная группа). Для автоматической табуляции всех показателей измерения пульсовой волны использовалась операционная система BPStat®, версия 05.00.04 («Petr Telegin», Россия). Статистическая обработка результатов проводилась с помощью пакета прикладных программ «Statistica 8».</p></sec><sec><title>Результаты</title><p>Результаты. Присутствие ФР уже в молодом возрасте ассоциировано с повышением параметров не только периферического, но и аортального АД, особенно систолического и пульсового, а также индекса аугментации центрального АД. Выявлены гендерные особенности этих нарушений. Наличие у студентов факторов риска сочетается с преимущественным повышением аортального АД по типу изолированной центральной (маскированной) или системной гипертензии/прегипертензии, подразумевающей повышение как периферического, так и аортального АД. Изолированное же повышение периферического АД на плечевой артерии встречается среди студентов-носителей ФР с частотой, аналогичной для группы лиц без этих факторов.</p></sec><sec><title>Выводы</title><p>Выводы. Методика контурного анализа центральной пульсовой волны у лиц молодого возраста позволяет определить участие различных механизмов в повышении давления на самых ранних стадиях формирования гипертензии/предгипертензии. Эти данные, в свою очередь, дают возможность осуществления дифференцированной донозологической диагностики изменений гемодинамического статуса у молодых представителей из группы риска. Такой подход будет способствовать осуществлению более индивидуализированных профилактических мероприятий среди молодого контингента.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To estimate central aortic blood pressure (BP) and index of augmentation in young people, taking into account the presence of risk factors (RF), during preventive medical examination.</p></sec><sec><title>Design and methods</title><p>Design and methods. Altogether 78 students of 3–4 years, aged 19–23 years old have been surveyed within the framework of the regular medical examinations, at the Center of Students’ Health, Stavropol State Medical University, as a part of the project “University is the territory of health”. Besides RF assessment, central aortic pressure was evaluated by oscillometric method (BPLab, “Peter Telegin”,Novosibirsk,Russia; Vasotens Office). In addition to common peripheral BP parameters, this technology provides measurements of systolic BP aortic (SYSао), diastolic BP aortic (DIAао), pulse BP aortic (PPао), average BP aortic (ABPао), left ventricular ejection duration (ED), augmentation index in aorta (AIxао), pulse pressure amplification (PPA) and subendocardial viability ratio (SEVR). Surveyed students were distributed into two groups: first group — without RF (control group), and second group — with RF (main group). For automatic tubulation of all parameters we used the operational system BPStat ® version 05.00.04 (“Petr Telegin”). For statistical data processing program “Statistica8” was used.</p></sec><sec><title>Results</title><p>Results. At young age RF are associated with the increase of both peripheral and aortic BP, especially systolic and pulse ВР, as well as augmentation index of central ВР. In students RF are associated with the increase of aortic BP (isolated central or masked hypertension/prehypertensionwith the simultaneous increase of both peripheral and aortic BP). The frequency of isolated increase of peripheral BP among students with RF is similar to that in students without RF.</p></sec><sec><title>Conclusions</title><p>Conclusions. Thus, planimetric analysis of central pulse wave in young people allows to define various mechanisms leading to the early BP increase. These data enable differentiated premorbid diagnostics of hemodynamic status in young adults with cardiovascular RF. This approach will contribute to the more individualized preventive measures in young population.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>лица молодого возраста</kwd><kwd>центральное аортальное давление</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>young adults</kwd><kwd>central аortic pressure</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization (WHO). The World Health Report about non-comminicable diseases. Geneva. 2010. [Internet]. Avaiabe from: http://patientsandpatents.wordpress. com/category/world-health-organization/page/2/.</mixed-citation><mixed-citation xml:lang="en">World Health Organization (WHO). The World Health Report about non-comminicable diseases. Geneva. 2010. [Internet]. 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