arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2018-24-5-521-530arthyper-1749Research ArticleОБЗОРREVIEWВозможности использования микроРНК в качестве биомаркера при диагностике инсультаMicroRnA as a diagnostic biomarker in strokeТопузоваМ. П.TopuzovaM. P.

Топузова Мария Петровна — кандидат медицинских наук, доцент кафедры неврологии и психиатрии, старший научный сотрудник НИЛ цереброваскулярной патологии НИО неврологии и нейрореабилитации. 

ул. Аккуратова, д. 2, Санкт-Петербург, 197341. 

Mariya P. Topuzova, MD, PhD, Senior Scientist, Associate Professor, Department of Neurology and Psychiatry, Senior Researcher, Research Laboratory of Cerebrovascular Pathology, Research Department of Neurology and Neurorehabilitation.

2 Akkuratov street, St Petersburg, 197341. 

topuzova_mp@almazovcentre.ruАлексееваТ. М.AlekseevaT. M.

Алексеева Татьяна Михайловна — доктор медицинских наук, заведующая кафедрой неврологии и психиатрии, заведующая НИЛ цереброваскулярной патологии НИО неврологии и нейрореабилитации. 

ул. Аккуратова, д. 2, Санкт-Петербург, 197341. 

Tat’yana M. Alekseeva, MD, PhD, DSc, Professor, Head, Department of Neurology and Psychiatry, Head, Research Laboratory of Cerebrovascular Pathology, Research Department of Neurology and Neurorehabilitation.

2 Akkuratov street, St Petersburg, 197341. 

ПанинаЕ. Б.PaninaE. B.

Панина Елена Борисовна — кандидат медицинских наук, доцент кафедры неврологии и психиатрии. 

ул. Аккуратова, д. 2, Санкт-Петербург, 197341. 

Elena B. Panina, MD, PhD, Associate Professor, Department of Neurology and Psychiatry.

2 Akkuratov street, St Petersburg, 197341. 

ВавиловаТ. В.VavilovaT. V.

Вавилова Татьяна Владимировна — доктор медицинских наук, профессор, заведующая кафедрой лабораторной медицины и генетики.

 

Tat’yana V. Vavilova, MD, PhD, DSc, Professor, Head, Department of Laboratory Medicine and Genetics.

2 Akkuratov street, St Petersburg, 197341. 

Федеральное государственное бюджетное учреждение   «Национальный медицинский исследовательский центр  имени B. A. Алмaзoвa» Министерства здравоохранения   Российской Федерации.РоссияAlmazov National Medical Research Centre.Russian Federation201822112018245521530Copyright © Топузова М.П., Алексеева Т.М., Панина Е.Б., Вавилова Т.В., 20182018Топузова М.П., Алексеева Т.М., Панина Е.Б., Вавилова Т.В.Topuzova M.P., Alekseeva T.M., Panina E.B., Vavilova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1749

Острое инсульт-индуцированное повреждение эндотелиальных клеток приводит к нарушению мозговой микроциркуляции и значительному повреждению ткани головного мозга. Несмотря на недавний прогресс терапии, способствующий повышению выживаемости после инсульта, диагностические подходы, направленные на раннюю точную идентификацию патогенетического подтипа, остаются ограниченными. МикроРНК являются перспективными кандидатами на роль новых биомаркеров инсульта. Настоящая статья посвящена обзору данных о связи инсульта с изменением уровней определенных циркулирующих микроРНК и перспективах их диагностического использования.

Acute stroke-induced damage of endothelial cells leads to impaired cerebral microcirculation and significant damage of the brain tissue. Despite recent advances in treatment approaches that improve survival after a stroke, diagnostic approaches aimed at early identification of the pathogenetic stroke subtype remain limited. MicroRNAs are promising biomarkers in stroke. The article reviews data on the relationship of stroke with changes in the levels of certain circulating microRNAs and the opportunities for their diagnostic use.

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The authors declare that there are no conflicts of interest present.