arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2014-20-4-307-319arthyper-18Research ArticleОБЗОРREVIEWЭФФЕКТИВНАЯ ИНАКТИВАЦИЯРЕНИН-АНГИОТЕНЗИН-АЛЬДОСТЕРОНОВОЙ СИСТЕМЫ: ВЫБОР В ПОЛЬЗУ ИНГИБИТОРОВ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТАEFFECTIVE INHIBITION OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM: THE ANGIOTENSIN-CONVERTING ENZYME INHIBITORS BENEFITSСтоловС. В.StolovS. V.

Доктор медицинских наук, заместитель главного терапевта Санкт-Петербурга, профессор кафедры терапии и ревматологии имени Э.Э. Эйхвальда ГБОУ ВПО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России.

Контактная информация: ГБОУ ВПО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России, ул. Кирочная, д. 41, Санкт-Петербург, Россия, 191015. E-mail: sergey.stolov@spbmapo.ru (Столов Сергей Валентинович).

Corresponding author: North-Western State Medical University named after I.I. Mechnikov,  41 Kirochnaya st., St Petersburg, Russia, 191015. E-mail:  sergey.stolov@spbmapo.ru (Sergey V. Stolov, MD, PhD, DSc, the Deputy Main Physician of St Petersburg, the Professor at the Department of the Internal Diseases and Rheumatology named after E.E. Eikhvald at the North-Western State Medical University named after I.I. Mechnikov).

sergey.stolov@spbmapo.ruСеверо-Западный государственный медицинский университет имени И.И. Мечникова, Санкт-ПетербургРоссияNorth-Western State Medical University named after I.I. Mechnikov, St PetersburgRussian Federation201427022015204307319Copyright © Столов С.В., 20152015Столов С.В.Stolov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/18

В обзорной статье проведена сравнительная оценка эффективности двух классов лекарственных препаратов — ингибиторов ангиотензинпревращающего фермента и блокаторов рецепторов ангиотензина II в профилактике сердечно-сосудистых заболеваний по данным ряда метаанализов. Показано, что блокаторы рецепторов ангиотензина II не обеспечивают эффективной защиты от основных сердечно-сосудистых рисков у больных ишемической болезнью сердца и цереброваскулярными болезнями.

The article reviews the evidence on the angiotensin-converting enzyme inhibitor vs. angiotensin receptor blocker in patients with cardiovascular diseases. Some negative effects of angiotensin receptor blocker regarding prognosis are demonstrated, including cardiovascular and total deaths, myocardial infarction and stroke.

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The authors declare that there are no conflicts of interest present.