arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2019-25-1-97-104arthyper-1804Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLEФакторы кардиометаболического риска у женщин с анамнезом артериальной гипертензии во время беременностиRisk factors for cardiovascular complications in women with hypertensive disorders during pregnancyТарасоваО. А.TarasovaO. A.

Тарасова Олеся Александровна — врач-терапевт женской консультации

 ул. Дзержинского, д. 15, г. Челябинск, 454129

Olesya A. Tarasova, MD, Physician, Maternity Out-Patient Clinic

17a Dzerzhinsky street, Chelyabinsk, 454129

Tarasova.o.a@bk.ruЧулковВ. С.ChulkovV. S.

Чулков Василий Сергеевич — кандидат медицинских наук, доцент кафедры факультетской терапии

Челябинск

Vasiliy S. Chulkov, MD, PhD, DSc, Associate Professor, Department of Internal Diseases

Chelyabinsk

СиницынС. П.SinitsinS. P.

Синицын Сергей Петрович — доктор медицинских наук, заведующий кафедрой факультетской терапии

Челябинск

Sergey P. Sinitsin, MD, PhD, DSc, Head, Department of Internal Diseases

Chelyabinsk

ВереинаН. К.VereinaN. K.

Вереина Наталья Константиновна — доктор медицинских наук, профессор кафедры факультетской терапии

Челябинск

Natalia K. Vereina, MD, PhD, DSc, Professor, Department of Internal Diseases

Chelyabinsk

ЧулковВл. С.ChulkovVl. S.

Чулков Владислав Сергеевич — ассистент кафедры факультетской терапии

Челябинск

Vladislav S. Chulkov, MD, Assistant, Department of Internal Diseases

Chelyabinsk

Муниципальное автономное учреждение здравоохранения  «Городская клиническая больница № 11»РоссияMunicipal Hospital № 11Russian FederationФедеральное государственное бюджетное образовательное  учреждение высшего образования «Южно-Уральский   государственный медицинский университет»   Министерства здравоохранения Российской ФедерацииРоссияSouth Ural State Medical UniversityRussian Federation20193003201925197104Copyright © Тарасова О.А., Чулков В.С., Синицын С.П., Вереина Н.К., Чулков В.С., 20192019Тарасова О.А., Чулков В.С., Синицын С.П., Вереина Н.К., Чулков В.С.Tarasova O.A., Chulkov V.S., Sinitsin S.P., Vereina N.K., Chulkov V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1804Цель исследования

Цель исследования. Мы провели кросс-секционное исследование факторов риска и биомаркеров сердечно-сосудистых заболеваний среди молодых женщин с гипертензивными нарушениями в сравнении с нормотензивными пациентками во время беременности.

Материалы и методы

Материалы и методы. Обследовано 117 женщин, из которых 33 — с гипертензивными нарушениями во время беременности, 44 — без гипертензивных нарушений во время беременности. Контрольную группу составили 40 женщин, не имевших беременности в анамнезе. Промежуток времени после родов в среднем составлял от 5 до 19 лет.

Результаты и выводы

Результаты и выводы. Показано, что у женщин с артериальной гипертензией (АГ) во время беременности в последующем при тщательном обследовании чаще выявляются изменения углеводного и липидного обмена в сочетании с АГ и абдоминальным ожирением, которые составляют кластер метаболического синдрома. Эти изменения также сопровождаются инсулинорезистентностью, гиперинсулинемией, дисбалансом адипокинов, изменениями показателей фибринолиза, а также более выраженными изменениями со стороны сердца и сосудов как органов-мишеней при АГ.

Objective

Objective. We performed a cross-sectional study of risk factors and biomarkers of cardiovascular diseases among young women with hypertensive disorders during pregnancy in comparison with women without hypertension during pregnancy.

Design and methods

Design and methods. Altogether 117 women were enrolled, 33 were included in the group of hypertensive disorders during pregnancy, and 44 formed the group without hypertension during pregnancy. The control group consisted of 40 patients. The time interval after delivery was on average 5 to 19 years.

Results and conclusions

Results and conclusions. Women with hypertension during pregnancy developed changes in carbohydrate and lipid metabolism associated with hypertension and abdominal obesity, which are the components of the cluster of the metabolic syndrome. These changes are also accompanied by insulin resistance, hyperinsulinemia, adipokine imbalance, changes in fbrinolysis and more pronounced remodeling of the heart and vessels as target organs in hypertension.

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The authors declare that there are no conflicts of interest present.