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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2019-25-1-105-115</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1805</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Артериальная гипертензия у беременных: взгляд с позиций Европейских рекомендаций 2018 года</article-title><trans-title-group xml:lang="en"><trans-title>Hypertension in pregnant women: a view from the perspective of the European recommendations 2018</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ших</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shih</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ших Евгения Валерьевна — доктор медицинских наук, профессор, заведующая кафедрой клинической фармакологии и пропедевтики внутренних болезней ФГАО УВО «ПМГМУ им. И. М. Сеченова» Минздрава России, директор Института профессионального образования ФГАО УВО «ПМГМУ им. И. М. Сеченова» Минздрава России</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgeniya V. Shih, MD, PhD, DSc, Professor, Head, Department for Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University, Director, Institute of Professional Education, Sechenov First Moscow State Medical University</p><p>Moscow</p></bio><email xlink:type="simple">chih@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жукова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukova</surname><given-names>О. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жукова Ольга Вадимовна — кандидат медицинских наук, ассистент кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga V. Zhukova, MD, PhD, Assistant, Department for Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>Moscow</p></bio><email xlink:type="simple">dr_zhukova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остроумова</surname><given-names>О. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostroumova</surname><given-names>O. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Остроумова Ольга Дмитриевна — доктор медицинских наук, профессор, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней ФГАО УВО «ПМГМУ им. И. М. Сеченова» Минздрава России, профессор кафедры факультетской терапии и профболезней ФГОУ ВО «МГМСУ им. А. И. Евдокимова» Минздрава России</p><p> </p></bio><bio xml:lang="en"><p>Olga D. Ostroumova, MD, PhD, DSc, Professor, Department for Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University, Professor, Department of Internal Diseases and Occuppational Diseases, A. I. Evdokimova Moscow State Medical-Stomatological University</p><p>8 Trubetskaya street, building 2, Moscow, 119991</p></bio><email xlink:type="simple">ostroumova.olga@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаронова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharonova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаронова Светлана Сергеевна — студентка лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Svetlana S. Sharonova, 4th year Student</p><p>Moscow</p></bio><email xlink:type="simple">lana.sh917@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карноух</surname><given-names>И. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Karnoukh</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карноух Константин Игоревич — ординатор кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>Москва</p></bio><bio xml:lang="en"><p>Konstantin I. Karnoukh, Postgraduate Student, Resident, Department for Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>Moscow</p></bio><email xlink:type="simple">comefl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное автономное  образовательное учреждение высшего образования  «Первый Московский государственный медицинский  университет имени И. М. Сеченова» Министерства  здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Sechenov First Moscow State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное автономное  образовательное учреждение высшего образования  «Первый Московский государственный медицинский  университет имени И. М. Сеченова» Министерства  здравоохранения Российской Федерации;&#13;
Федеральное государственное образовательное учреждение  высшего образования «Московский государственный  медико-стоматологический университет  имени А. И. Евдокимова» Министерства здравоохранения  Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Sechenov First Moscow State Medical University;&#13;
A. I. Evdokimova Moscow State Medical-Stomatological  University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2019</year></pub-date><volume>25</volume><issue>1</issue><fpage>105</fpage><lpage>115</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ших Е.В., Жукова О.В., Остроумова О.Д., Шаронова С.С., Карноух И.К., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Ших Е.В., Жукова О.В., Остроумова О.Д., Шаронова С.С., Карноух И.К.</copyright-holder><copyright-holder xml:lang="en">Shih E.V., Zhukova О.V., Ostroumova O.D., Sharonova S.S., Karnoukh K.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1805">https://htn.almazovcentre.ru/jour/article/view/1805</self-uri><abstract><p>Актуальность проблемы артериальной гипертензии (АГ) у беременных обусловлена ее высокой распространенностью и тяжестью последствий для матери и плода. В РФ АГ диагностируется у 5–30% беременных, на протяжении последних десятилетий отмечается тенденция к увеличению этого показателя. Наличие АГ является фактором риска развития различных осложнений, как со стороны матери, так и со стороны плода и новорожденного. АГ остается ведущей причиной материнской, фетальной и неонатальной смертности. АГ у беременных является значимым предиктором развития сердечно-сосудистой патологии в будущем. Данная проблема имеет и социальный аспект — повышение расходов на лечение, в том числе и в связи с повторными госпитализациями после родов. В 2018 году вышли новые Европейские рекомендации по сердечно-сосудистым заболеваниям во время беременности и Европейские рекомендации по артериальной гипертензии, в которых имеются специальные разделы, посвященные АГ у беременных. В этих рекомендациях представлены последние данные по классификации, диагностике и терапии АГ у беременных. В настоящее время по-прежнему препаратом первой линии для лечения АГ у беременных является метилдопа, который зарекомендовал себя как эффективный и безопасный препарат при лечении АГ у беременных.</p></abstract><trans-abstract xml:lang="en"><p>The problem of arterial hypertension (HTN) in pregnant women is very important due to its high prevalence and severity of consequences for the mother and fetus. In Russia, hypertension is diagnosed in 5–30% pregnant women, with the increasing trend in the past decades. HTN is a risk factor for complications, both for the mother, the fetus and newborn, so HTN remains the leading cause of maternal, fetal and neonatal mortality. HTN in pregnant women is a signifcant predictor of cardiovascular disease in the future. It is also a social problem considering the increase in the cost of treatment, i.e. related to the repeated hospitalizations after childbirth. In 2018, new European recommendations on cardiovascular diseases during pregnancy and European recommendations on HTN (the latter ones include special sections devoted to hypertension in pregnant women) were published. These recommendations provide the latest data on the classifcation, diagnosis and treatment of HTN in pregnant women. Currently, methyldopa is still the frst-line drug for the treatment of HTN in pregnant women, which has proved to be an effective and safe medication in pregnant women.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>беременность</kwd><kwd>гестационная гипертензия</kwd><kwd>преэклампсия</kwd><kwd>антигипертензивная терапия</kwd><kwd>метилдопа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>pregnancy</kwd><kwd>gestational hypertension</kwd><kwd>preeclampsia</kwd><kwd>antihypertensive therapy</kwd><kwd>methyldopa</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Артериальная гипертония у беременных. 2016. https://medi.ru/klinicheskie-rekomendatsii/arterialnaya-gipertoniya-u-beremennykh_13865.</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations. Arterial hypertension in pregnant women. 2016. https://medi.ru/klinicheskie-rekomendatsii/arterialnaya-gipertoniyau-beremennykh_13865. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Манухин И.Б., Маркова Е.В., Маркова Л.И., Стрюк Р.И. Комбинированная низкодозовая антигипертензивная терапия у беременных с артериальной гипертонией и гестозом. Кардиология. 2012;52(1):32–38.</mixed-citation><mixed-citation xml:lang="en">Manuhin IB, Markova EV, Markova LI, Stryuk RI. Combined low-dose antihypertensive therapy in pregnant women with arterial hypertension and gestosis. Kardiologiia. 2012;52(1):32–38. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кирсанова Т.В., Михайлова О.И. Принципы лечения артериальной гипертонии при беременности. РМЖ. 2012;21:1097.</mixed-citation><mixed-citation xml:lang="en">Kirsanova TV, Mikhailova OI. Principles of treatment of arterial hypertension during pregnancy. Russian Medical Journal. 2012;21: 1097. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Верткин А. Л., Ткачева О. Н., Мурашко Л. Е., Тумбаев И.В., Мишина И.Е. Артериальная гипертония беременных: диагностика, тактика ведения и подходы к лечению. Лечащий врач. 2006;3:25–28.</mixed-citation><mixed-citation xml:lang="en">Vertkin AL, Tkacheva ON, Murashko LE, Tumbaev IV, Mishina IE. Arterial hypertension of pregnant women: diagnosis, management tactics and approaches to treatment. Lechashchij Vrach = The Physician. 2006;3:25–8. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Madi JM, Araújo BF, Zatti H, Rombaldi RL, Madi SR, de Zorzi P et al. Chronic hypertension and pregnancy at a tertiary-care and university hospital. Hypertens Pregnancy. 2012;31(3):350–356. doi:10.3109/10641955.2010.525279</mixed-citation><mixed-citation xml:lang="en">Madi JM, Araújo BF, Zatti H, Rombaldi RL, Madi SR, de Zorzi P et al. Chronic hypertension and pregnancy at a tertiary-care and university hospital. Hypertens Pregnancy. 2012;31(3):350–356. doi:10.3109/10641955.2010.525279</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Magee LA, von Dadelszen P, Singer J, Lee T, Rey E, Ross S, CHIPS Study Group. The CHIPS Randomized Controlled Trial (Control of Hypertensionin Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure? Hypertension. 2016;68(5):1153– 1159. doi:10.1161/HYPERTENSIONAHA.116.07862</mixed-citation><mixed-citation xml:lang="en">Magee LA, von Dadelszen P, Singer J, Lee T, Rey E, Ross S, CHIPS Study Group. The CHIPS Randomized Controlled Trial (Control of Hypertensionin Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure? Hypertension. 2016;68(5):1153– 1159. doi:10.1161/HYPERTENSIONAHA.116.07862</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tooher J, Thornton C, Makris A, Ogle R, Korda A, Hennessy A. All hypertensive disorders of pregnancy increase the risk of future cardiovascular disease. Annals of Internal Medicine. 2018;169(4):224–232. doi:10.7326/M17-2740</mixed-citation><mixed-citation xml:lang="en">Tooher J, Thornton C, Makris A, Ogle R, Korda A, Hennessy A. All hypertensive disorders of pregnancy increase the risk of future cardiovascular disease. Annals of Internal Medicine. 2018;169(4):224–232. doi:10.7326/M17-2740</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Stuart JJ, Tanz LJ, Missmer SA, Rimm EB, Spiegelman D, James-Todd TM et al. Hypertensive disorders of pregnancy and maternal cardiovascular disease risk factor development: an observational cohort study. Ann Intern Med. 2018;169(4):224–232. doi:10.7326/M17–2740</mixed-citation><mixed-citation xml:lang="en">Stuart JJ, Tanz LJ, Missmer SA, Rimm EB, Spiegelman D, James-Todd TM et al. Hypertensive disorders of pregnancy and maternal cardiovascular disease risk factor development: an observational cohort study. Ann Intern Med. 2018;169(4):224–232. doi:10.7326/M17–2740</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mulubrhan F, Salemi JL, Spooner KK, McFarlin BL, Salihu HH. Hypertensive disorders of pregnancy and postpartum readmissionin the United States: national surveillance of the revolving door Mogos. J Hypertens. 2018;36(3):608–618. doi:10.1097/HJH.0000000000001594</mixed-citation><mixed-citation xml:lang="en">Mulubrhan F, Salemi JL, Spooner KK, McFarlin BL, Salihu HH. Hypertensive disorders of pregnancy and postpartum readmissionin the United States: national surveillance of the revolving door Mogos. J Hypertens. 2018;36(3):608–618. doi:10.1097/HJH.0000000000001594</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">2018 ESC Guidelines for the management of cardiovascular disease during pregnancy. Eur Heart J. 2018; 39(34):3165–3241. doi:10.1093/eurheartj/ehy340</mixed-citation><mixed-citation xml:lang="en">2018 ESC Guidelines for the management of cardiovascular disease during pregnancy. Eur Heart J. 2018; 39(34):3165–3241. doi:10.1093/eurheartj/ehy340</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018; 39(33):3021–3104. doi:10.1093/eurheartj/ehy339</mixed-citation><mixed-citation xml:lang="en">2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018; 39(33):3021–3104. doi:10.1093/eurheartj/ehy339</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Villar J, Carroli G, Wojdyla D, Abalos E, Giordano D, Ba’aqeel H et al. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am J Obstet Gynecol. 2006;194(4):921–931. doi:10.1016/j.ajog.2005.10.813</mixed-citation><mixed-citation xml:lang="en">Villar J, Carroli G, Wojdyla D, Abalos E, Giordano D, Ba’aqeel H et al. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am J Obstet Gynecol. 2006;194(4):921–931. doi:10.1016/j.ajog.2005.10.813</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Penny JA, Halligan AW, Shennan AH, Lambert PC, Jones DR, de Swiet M et al. Automated, ambulatory, or conventional blood pressure measurement in pregnancy: which is the better predictor of severe hypertension? Am J Obstet Gynecol. 1998;178(3):521–526.</mixed-citation><mixed-citation xml:lang="en">Penny JA, Halligan AW, Shennan AH, Lambert PC, Jones DR, de Swiet M et al. Automated, ambulatory, or conventional blood pressure measurement in pregnancy: which is the better predictor of severe hypertension? Am J Obstet Gynecol. 1998;178(3):521–526.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Magee LA, Ramsay G, von Dadelszen P. What is the role of out-of-offce BP measurement in hypertensive pregnancy? Hypertens Pregnancy 2008;27(2):95–101. doi:10.1080/10641950801950197</mixed-citation><mixed-citation xml:lang="en">Magee LA, Ramsay G, von Dadelszen P. What is the role of out-of-offce BP measurement in hypertensive pregnancy? Hypertens Pregnancy 2008;27(2):95–101. doi:10.1080/10641950801950197</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Schmella MJ, Clifton RG, Althouse AD, Roberts JM. Uric acid determination in gestational hypertension: Is it as effective a delineator of risk as proteinuria in high-risk women? Reprod Sci. 2015;22(10):1212–1219. doi:10.1177/1933719115572477</mixed-citation><mixed-citation xml:lang="en">Schmella MJ, Clifton RG, Althouse AD, Roberts JM. Uric acid determination in gestational hypertension: Is it as effective a delineator of risk as proteinuria in high-risk women? Reprod Sci. 2015;22(10):1212–1219. doi:10.1177/1933719115572477</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cade TJ, de Crespigny PC, Nguyen T, Cade JR, Umstad MP. Should the spot albumin-to-creatinine ratio replace the spot proteinto-creatinine ratio as the primary screening tool for proteinuria in pregnancy? Pregnancy Hypertens. 2015;5(4):298–302. doi:10.1016/j.preghy.2015.07.001</mixed-citation><mixed-citation xml:lang="en">Cade TJ, de Crespigny PC, Nguyen T, Cade JR, Umstad MP. Should the spot albumin-to-creatinine ratio replace the spot proteinto-creatinine ratio as the primary screening tool for proteinuria in pregnancy? Pregnancy Hypertens. 2015;5(4):298–302. doi:10.1016/j.preghy.2015.07.001</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Chappell LC, Shennan AH. Assessment of proteinuria in pregnancy. BMJ 2008;336(7651):968–969. doi:10.1136/bmj.39540.657928.BE</mixed-citation><mixed-citation xml:lang="en">Chappell LC, Shennan AH. Assessment of proteinuria in pregnancy. BMJ 2008;336(7651):968–969. doi:10.1136/bmj.39540.657928.BE</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cote AM, Firoz T, Mattman A, Lam EM, von Dadelszen P, Magee LA. The 24hour urine collection: gold standard or historical practice? Am J Obstet Gynecol. 2008;199(6):621–626. doi:10.1016/j.ajog.2008.06.009</mixed-citation><mixed-citation xml:lang="en">Cote AM, Firoz T, Mattman A, Lam EM, von Dadelszen P, Magee LA. The 24hour urine collection: gold standard or historical practice? Am J Obstet Gynecol. 2008;199(6):621–626. doi:10.1016/j.ajog.2008.06.009</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstrom M et al. Predictive value of the sFlt-1: PIGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374 (1):13–22. doi:10.1056/NEJMoa1414838</mixed-citation><mixed-citation xml:lang="en">Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstrom M et al. Predictive value of the sFlt-1: PIGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374 (1):13–22. doi:10.1056/NEJMoa1414838</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Leanos-Miranda A, Campos-Galicia I, Isordia-Salas I, Rivera-Leanos R, RomeroArauz JF, Ayala-Mendez JA et al. Changes in circulating concentrations of soluble fms-like tyrosine kinase-1 and placental growth factor measured by automated ele ctrochemiluminescence immunoassays methods are predictors of preeclampsia. J Hypertens. 2012;30(11):2173–2181. doi:10.1097/HJH.0b013e328357c0c9</mixed-citation><mixed-citation xml:lang="en">Leanos-Miranda A, Campos-Galicia I, Isordia-Salas I, Rivera-Leanos R, RomeroArauz JF, Ayala-Mendez JA et al. Changes in circulating concentrations of soluble fms-like tyrosine kinase-1 and placental growth factor measured by automated ele ctrochemiluminescence immunoassays methods are predictors of preeclampsia. J Hypertens. 2012;30(11):2173–2181. doi:10.1097/HJH.0b013e328357c0c9</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M et al; Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology. J Hypertens. 2013;31(10):1281–1357. doi:10.3109/08037051.2014.868629</mixed-citation><mixed-citation xml:lang="en">Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M et al; Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology. J Hypertens. 2013;31(10):1281–1357. doi:10.3109/08037051.2014.868629</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122 (5):1122–1131. doi:10.1097/01.AOG.0000437382.03963.88</mixed-citation><mixed-citation xml:lang="en">American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122 (5):1122–1131. doi:10.1097/01.AOG.0000437382.03963.88</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertens. 2014;4(2):105–145. doi:10.1016/j.preghy.2014.01.003</mixed-citation><mixed-citation xml:lang="en">Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertens. 2014;4(2):105–145. doi:10.1016/j.preghy.2014.01.003</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lowe SA, Bowyer L, Lust K, McMahon LP, Morton MR, North RA et al. The somanz guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynaecol. 2015;55(5):11–16. doi:10.1111/ajo.12253</mixed-citation><mixed-citation xml:lang="en">Lowe SA, Bowyer L, Lust K, McMahon LP, Morton MR, North RA et al. The somanz guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynaecol. 2015;55(5):11–16. doi:10.1111/ajo.12253</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, Cifkova R, Ferreira R, Foidart JM et al. ESC guidelines on the management of cardiovascular diseases during pregnancy. Eur Heart J. 2011;32(24):3147–3197. doi:10.1093/eurheartj/ehr218</mixed-citation><mixed-citation xml:lang="en">Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, Cifkova R, Ferreira R, Foidart JM et al. ESC guidelines on the management of cardiovascular diseases during pregnancy. Eur Heart J. 2011;32(24):3147–3197. doi:10.1093/eurheartj/ehr218</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">National Collaborating Centre for Women’s and Children’s Health (UK). Hypertension in pregnancy: The management of hypertensive disorders during pregnancy. London: RCOG Press; 2010.</mixed-citation><mixed-citation xml:lang="en">National Collaborating Centre for Women’s and Children’s Health (UK). Hypertension in pregnancy: The management of hypertensive disorders during pregnancy. London: RCOG Press; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco Matallana C et al. Aspirin versus placebo in pregnancies at high-risk for preterm preeclampsia. N Engl J Med. 2017;377 (7):613–622. doi:10.1056/NEJMoa1704559</mixed-citation><mixed-citation xml:lang="en">Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco Matallana C et al. Aspirin versus placebo in pregnancies at high-risk for preterm preeclampsia. N Engl J Med. 2017;377 (7):613–622. doi:10.1056/NEJMoa1704559</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2014;6. doi:10.1002/14651858.CD001059.pub4</mixed-citation><mixed-citation xml:lang="en">Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2014;6. doi:10.1002/14651858.CD001059.pub4</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Xu H, Perez-Cuevas R, Xiong X, Reyes H, Roy C, Julien P et al. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol. 2010;202(3):239. e1–239.e10. doi:10.1016/j.ajog.2010.01.050</mixed-citation><mixed-citation xml:lang="en">Xu H, Perez-Cuevas R, Xiong X, Reyes H, Roy C, Julien P et al. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol. 2010;202(3):239. e1–239.e10. doi:10.1016/j.ajog.2010.01.050</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Villar J, Purwar M, Merialdi M, Zavaleta N, Thi Nhu Ngoc N, Anthony J et al. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high-risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG. 2009;116 (6):780–788. doi:10.1111/j.1471–0528.2009.02158.x</mixed-citation><mixed-citation xml:lang="en">Villar J, Purwar M, Merialdi M, Zavaleta N, Thi Nhu Ngoc N, Anthony J et al. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high-risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG. 2009;116 (6):780–788. doi:10.1111/j.1471–0528.2009.02158.x</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Spinnato JA II, Freire S, Pinto ESJL, Cunha Rudge MV, Martins-Costa S, Koch MA et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110 (6):1311–1318. doi:10.1097/01.AOG.0000289576.43441.1f.</mixed-citation><mixed-citation xml:lang="en">Spinnato JA II, Freire S, Pinto ESJL, Cunha Rudge MV, Martins-Costa S, Koch MA et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110 (6):1311–1318. doi:10.1097/01.AOG.0000289576.43441.1f.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): Randomised placebocontrolled trial. Lancet. 2006;367(9517):1145–1154. doi:10.1016/S0140-6736(06)68 433-X</mixed-citation><mixed-citation xml:lang="en">Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): Randomised placebocontrolled trial. Lancet. 2006;367(9517):1145–1154. doi:10.1016/S0140-6736(06)68 433-X</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Redman CW. Fetal outcome in trial of antihypertensive treatment in pregnancy. Lancet. 1976;2(7989):753–756.</mixed-citation><mixed-citation xml:lang="en">Redman CW. Fetal outcome in trial of antihypertensive treatment in pregnancy. Lancet. 1976;2(7989):753–756.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cockburn J, Moar VA, Ounsted M, Redman CW. Final report of study on hypertension during pregnancy: The effects of specifc treatment on the growth and development of the children. Lancet. 1982;1(8273):647–649.</mixed-citation><mixed-citation xml:lang="en">Cockburn J, Moar VA, Ounsted M, Redman CW. Final report of study on hypertension during pregnancy: The effects of specifc treatment on the growth and development of the children. Lancet. 1982;1(8273):647–649.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Dodd JM, Turnbull D, McPhee AJ, Deussen AR, Grivell RM, Yelland LN et al. Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. BMJ. 2014;348:1285. doi:10.1136/bmj.g1285</mixed-citation><mixed-citation xml:lang="en">Dodd JM, Turnbull D, McPhee AJ, Deussen AR, Grivell RM, Yelland LN et al. Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. BMJ. 2014;348:1285. doi:10.1136/bmj.g1285</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Leddy MA, Power ML, Schulkin J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol. 2008;1 (4):170–178.</mixed-citation><mixed-citation xml:lang="en">Leddy MA, Power ML, Schulkin J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol. 2008;1 (4):170–178.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Abalos E, Duley L, Steyn DW, Gialdini C. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2014;2: CD002252. doi:10.1002/14651858.CD002252.pub3</mixed-citation><mixed-citation xml:lang="en">Abalos E, Duley L, Steyn DW, Gialdini C. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2014;2: CD002252. doi:10.1002/14651858.CD002252.pub3</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Shekhar S, Gupta N, Kirubakaran R, Pareek P. Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis. BJOG. 2016;123(1):40–47. doi:10.1111/1471-0528.13463</mixed-citation><mixed-citation xml:lang="en">Shekhar S, Gupta N, Kirubakaran R, Pareek P. Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis. BJOG. 2016;123(1):40–47. doi:10.1111/1471-0528.13463</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Clark SM, Dunn HE, Hankins GD. A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy. Semin Perinatol. 2015;39(7):548–555. doi:10.1053/j.semperi.2015.08.011</mixed-citation><mixed-citation xml:lang="en">Clark SM, Dunn HE, Hankins GD. A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy. Semin Perinatol. 2015;39(7):548–555. doi:10.1053/j.semperi.2015.08.011</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J et al. Do women with pre-eclampsia, and their babies, beneft from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet. 2002;359(9321):1877–1890.</mixed-citation><mixed-citation xml:lang="en">Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J et al. Do women with pre-eclampsia, and their babies, beneft from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet. 2002;359(9321):1877–1890.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ et al; HYPITAT study group. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial. Lancet. 2009;374(9694):979–988. doi:10.1016/S0140-6736(09)60736-4</mixed-citation><mixed-citation xml:lang="en">Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ et al; HYPITAT study group. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial. Lancet. 2009;374(9694):979–988. doi:10.1016/S0140-6736(09)60736-4</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hilfker-Kleiner D, Haghikia A, Nonhoff J, Bauersachs J. Peripartum cardiomyopathy: current management and future perspectives. Eur Heart J. 2015;36(18):1090–1097. doi:10.1093/eurheartj/ehv009</mixed-citation><mixed-citation xml:lang="en">Hilfker-Kleiner D, Haghikia A, Nonhoff J, Bauersachs J. Peripartum cardiomyopathy: current management and future perspectives. Eur Heart J. 2015;36(18):1090–1097. doi:10.1093/eurheartj/ehv009</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Beardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregnancy. 2002;21(1):85–95. doi:10.1081/PRG-120002912</mixed-citation><mixed-citation xml:lang="en">Beardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregnancy. 2002;21(1):85–95. doi:10.1081/PRG-120002912</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet. 2005;366(9499):1797–1803. doi:10.1016/S0140-6736(05)67726–4</mixed-citation><mixed-citation xml:lang="en">Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet. 2005;366(9499):1797–1803. doi:10.1016/S0140-6736(05)67726–4</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Black MH, Zhou H, Sacks DA, Dublin S, Lawrence JM, Harrison TN et al. Hypertensive disorders first identified in pregnancy increase risk for incident prehypertension and hypertension in the year after delivery. J Hypertens. 2016;34 (4):728–735. doi:10.1097/HJH.0000000000000855</mixed-citation><mixed-citation xml:lang="en">Black MH, Zhou H, Sacks DA, Dublin S, Lawrence JM, Harrison TN et al. Hypertensive disorders first identified in pregnancy increase risk for incident prehypertension and hypertension in the year after delivery. J Hypertens. 2016;34 (4):728–735. doi:10.1097/HJH.0000000000000855</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sibai BM, Mabie WC, Shamsa F, Villar MA, Anderson GD. A comparison of no medication versus methyldopa or labetalol in chronic hypertension during pregnancy. Am J Obstet Gynecol. 1990;162(4):960–966; discussion 966.</mixed-citation><mixed-citation xml:lang="en">Sibai BM, Mabie WC, Shamsa F, Villar MA, Anderson GD. A comparison of no medication versus methyldopa or labetalol in chronic hypertension during pregnancy. Am J Obstet Gynecol. 1990;162(4):960–966; discussion 966.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Weitz C, Khouzami V, Maxwell K, Johnson JW. Treatment of hypertension in pregnancy with methyldopa: a randomized double blind study. Int J Gynaecol Obstet. 1987;25(1):35–40.</mixed-citation><mixed-citation xml:lang="en">Weitz C, Khouzami V, Maxwell K, Johnson JW. Treatment of hypertension in pregnancy with methyldopa: a randomized double blind study. Int J Gynaecol Obstet. 1987;25(1):35–40.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Briggs GG, Freeman RK. Drugs in Pregnancy and Lactation. Philadelphia: Lippincott Williams &amp; Wilkins; 2014, 231 р.</mixed-citation><mixed-citation xml:lang="en">Briggs GG, Freeman RK. Drugs in Pregnancy and Lactation. Philadelphia: Lippincott Williams &amp; Wilkins; 2014, 231 р.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">de Jonge L, Zetstra-van der Woude PA, Bos HJ, de Jongvan den Berg LT, Bakker MK. Identifying associations between maternal medication use and birth defects using a case-population approach: an exploratorystudy on signal detection. Drug Saf. 2013;36(11):1069–1078. doi:10.1007/s40264-013-0082-2</mixed-citation><mixed-citation xml:lang="en">de Jonge L, Zetstra-van der Woude PA, Bos HJ, de Jongvan den Berg LT, Bakker MK. Identifying associations between maternal medication use and birth defects using a case-population approach: an exploratorystudy on signal detection. Drug Saf. 2013;36(11):1069–1078. doi:10.1007/s40264-013-0082-2</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeltzenbein M, Beck E, Fietz AK, Wernicke J, Zinke S, Kayser A et al. Pregnancy outcome after frst trimester use of methyldopa a prospective cohort study. Hypertension. 2017;70 (1):201–208. doi:10.1161/HYPERTENSIONAHA.117.09110</mixed-citation><mixed-citation xml:lang="en">Hoeltzenbein M, Beck E, Fietz AK, Wernicke J, Zinke S, Kayser A et al. Pregnancy outcome after frst trimester use of methyldopa a prospective cohort study. Hypertension. 2017;70 (1):201–208. doi:10.1161/HYPERTENSIONAHA.117.09110</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
