arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2019-25-3-225-231arthyper-1813Research ArticleСтатьиArticlesРоль инсулинорезистентности и артериальной гипертензии в процессах репликативного клеточного старенияReplicative cell ageing: the role of insulin resistance in patients with arterial hypertensionhttps://orcid.org/0000-0001-7891-6850ДудинскаяЕ. Н.DudinskayaE. N.

Дудинская Екатерина Наильевна — кандидат медицинских наук, заведующая лабораторией возрастных метаболических эндокринных нарушений.

1-ая Леонова ул., д. 16, Москва, 129226

Ekaterina N. Dudinskaya - MD, PhD, Head, Laboratory of the Age-related Metabolic and Endocrine Disorders.

16, 1st Leonov street, Moscow, 129226

katharina.gin@gmail.comhttps://orcid.org/0000-0002-4193-688XТкачеваО. Н.TkachevaO. N.

Ткачева Ольга Николаевна — доктор медицинских наук, профессор, директор.

Москва

Olga N. Tkacheva - MD, PhD, DSc, Professor, Director.

ontkacheva@gmail.comhttps://orcid.org/0000-0002-2028-3939МачехинаЛ. В.MatchekhinaL. V.

Мачехина Любовь Викторовна — кандидат медицинских наук, научный сотрудник лаборатории возрастных метаболических эндокринных нарушений.

Москва

Lyubov V. Matchekhina - MD, PhD, Researcher, Laboratory of the Age-related Metabolic and Endocrine Disorders.

Moscow

mlv66@list.ruhttps://orcid.org/0000-0002-1628-5093КотовскаяЮ. В.KotovskayaYu. V.

Котовская Юлия Викторовна—доктор медицинских наук, профессор, заместитель директора по научной работе.

Москва

Yulia V. Kotovskaya - MD, PhD, DSc, Professor, Deputy Director on Research.

Moscow

kotovskaya@bk.ruЛеонтьеваИ. В.LeontevaI. V.

Леонтьева Ирина Викторовна — доктор медицинских наук, профессор, главный научный сотрудник отдела детской кардиологии и аритмологии.

Irina V. Leontieva - MD, PhD, DSc, Professor, Leading Researcher, Department of Peadiatrics Cardiology and Arrhythmology.

Moscow

lirina2006@mail.ruhttps://orcid.org/0000-0001-8491-0228КовалевИ. А.KovalevI. A.

Ковалев Игорь Александрович — доктор медицинских наук, профессор, заведующий отделом детской кардиологии и аритмологии.

Igor A. Kovalev - MD, PhD, DSc, Professor, Head, Department of Peadiatrics Cardiology and Arrhythmology.

Moscow

kovalev@pedklin.ruhttps://orcid.org/0000-0001-7115-0186ШкольниковаМ. А.ShkolnikovaM. A.

Школьникова Мария Александровна — доктор медицинских наук, профессор, научный руководитель.

Москва

Maria A. Shkolnikova - MD, PhD, DSc, Professor, Research Leader.

Moscow

arrithmolog@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации, Обособленное структурное подразделение Российский геронтологический научноклинический центрРоссияPirogov Russian National Research Medical University of Ministry of Health of Russian federation Russian Gerontology Research and Clinical CentreRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России, Обособленное структурное подразделение Научно-исследовательский клинический институт педиатрии им. Ю.Е. ВельтищеваРоссияPirogov Russian National Research Medical University of Ministry of Health of Russian federation The Research and Clinical Institute for Pediatrics named after Academician Yuri VeltischevRussian Federation201931082019253225231Copyright © Дудинская Е.Н., Ткачева О.Н., Мачехина Л.В., Котовская Ю.В., Леонтьева И.В., Ковалев И.А., Школьникова М.А., 20192019Дудинская Е.Н., Ткачева О.Н., Мачехина Л.В., Котовская Ю.В., Леонтьева И.В., Ковалев И.А., Школьникова М.А.Dudinskaya E.N., Tkacheva O.N., Matchekhina L.V., Kotovskaya Y.V., Leonteva I.V., Kovalev I.A., Shkolnikova M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1813

В обзоре изложены основные сведения о процессах репликативного клеточного и сосудистого старения. Особое внимание уделяется проблеме артериальной гипертензии (АГ) и инсулинорезистентности (ИР). Обсуждаются механизмы возникновения ИР и АГ, их роль в развитии основных возраст-ассоциированных изменений сосудов, трансформации старения сосудов в болезнь, вклад в продолжительность жизни. Рассматриваются возможные пути воздействия на данные процессы.

The review presents basic information about the processes of replicative cellular and vascular aging. Special attention is paid to the problem of hypertension and insulin resistance. The mechanisms of the onset of insulin resistance and hypertension, their role in the development of major age-related vascular changes, the transformation of vascular aging into disease, and their contribution to life expectancy are discussed. Possible ways of influencing these processes are considered.

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The authors declare that there are no conflicts of interest present.