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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2020-26-4-371-382</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1874</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Гендерные особенности патогенеза, профилактики и лечения метаболического синдрома</article-title><trans-title-group xml:lang="en"><trans-title>Gender characteristics of the pathogenesis, prevention and treatment of metabolic syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0952-6856</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чулков</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chulkov</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чулков Василий Сергеевич — доктор медицинских наук, профессор кафедры факультетской терапии ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Vasiliy S. Chulkov MD, PhD, DSc, Professor, Department of Internal Diseases.</p><p>Chelyabinsk</p></bio><email xlink:type="simple">vschulkov@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8023-5309</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ленец</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lenets</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ленец Елизавета Анатольевна — лаборант кафедры фа-культетской терапии ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Elizaveta A. Lenets Laboratory assistant, Department of Internal Diseases.</p><p>Chelyabinsk</p></bio><email xlink:type="simple">liza.lenetz@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1948-8523</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чулков</surname><given-names>Вл. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chulkov</surname><given-names>Vl. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чулков Владислав Сергеевич — ассистент кафедры фа-культетской терапии ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Vladislav S. Chulkov MD, Assistant, Department of Internal Diseases.</p><p>Chelyabinsk</p></bio><email xlink:type="simple">vlad.chulkov.1989@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7137-6935</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаврилова Елена Сергеевна—кандидат медицинских наук, доцент кафедры поликлинической терапии и клинической фармакологии ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Elena S. Gavrilova MD, PhD, Associate Professor, Department of Outpatient Therapy and Clinical Pharmacology.</p><p>Chelyabinsk</p></bio><email xlink:type="simple">helengavrilova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1405-251X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минина</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Minina</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минина Елена Евгеньевна — старший лаборант кафедры факультетской педиатрии ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Elena E. Minina Senior Laboratory Assistant, Department of Pediatrics.</p></bio><email xlink:type="simple">eminina79@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3492-7395</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жданова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdanova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жданова Ольга Вячеславовна—студентка VI курса лечеб-ного факультета ФГБОУ ВО ЮУГМУ МЗ РФ.</p><p>Челябинск</p></bio><bio xml:lang="en"><p>Olga V Zhdanova 6th year student, Medical Faculty.</p></bio><email xlink:type="simple">zhdanova2103@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>22</day><month>08</month><year>2020</year></pub-date><volume>26</volume><issue>4</issue><fpage>371</fpage><lpage>382</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чулков В.С., Ленец Е.А., Чулков В.С., Гаврилова Е.С., Минина Е.Е., Жданова О.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Чулков В.С., Ленец Е.А., Чулков В.С., Гаврилова Е.С., Минина Е.Е., Жданова О.В.</copyright-holder><copyright-holder xml:lang="en">Chulkov V.S., Lenets E.A., Chulkov V.S., Gavrilova E.S., Minina E.E., Zhdanova O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1874">https://htn.almazovcentre.ru/jour/article/view/1874</self-uri><abstract><p>Научный и практический интерес к проблеме метаболического синдрома на сегодняшний день определяется его широким распространением. Формирование метаболического синдрома зависит от влияния различных факторов (возраст, раса, социально-экономический статус, уровень физической активности, культурное развитие, рацион питания, генетический фон и уровень образования). Целью данной статьи является рассмотрение гендерной специфики метаболического синдрома. Были изучены ключевые компоненты метаболического синдрома, такие как артериальная гипертензия, инсулинорезистентность, ожирение и дислипидемия. Каждый из компонентов был проанализирован с позиции гендерных различий таким образом, чтобы впоследствии проводить профилактику и выбирать адекватную терапию метаболического синдрома в зависимости от половой принадлежности.</p></abstract><trans-abstract xml:lang="en"><p>Metabolic syndrome (MS) is widespread which explains high relevance of the topic. The MS development depends on various factors (age, race, social and economic status, level of physical activity, cultural development, diet, genetic background and educational level). Traditionally, the MS assessment and cardiovascular risk stratification includes measurement of total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, as well as glucose and insulin levels. Some other factors are being investigated and might serve as the surrogate endpoints for the effectiveness of treatment and prevention strategies in addition to insulin resistance indices (HOMA-IR, Caro). These include some systemic biomarkers such as highly sensitive C-reactive protein, leptin and adiponectin, which mediate the link between inflammation and obesity, as well as potentially prognostic markers of cardiovascular diseases. The paper considers the gender specificity of the MS and main components of the MS, such as hypertension, insulin resistance, obesity, and dyslipidemia. We review different approaches of international guidelines and specific regional and national characteristics and analyze gender-related peculiarities of each component of the MS in order to justify an individualized choice of management approach.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>метаболический синдром</kwd><kwd>сердечно-сосудистый риск</kwd><kwd>артериальная гипертензия</kwd><kwd>инсулинорезистентность</kwd><kwd>ожирение</kwd><kwd>дислипидемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metabolic syndrome</kwd><kwd>cardiovascular risk</kwd><kwd>hypertension</kwd><kwd>insulin resistance</kwd><kwd>obesity</kwd><kwd>dyslipidemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Grundy SM, Hansen B, Smith SC, Cleeman JI, Kahn RA. 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