<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2020-26-2-133-145</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1945</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Сосудистое старение в концепциях EVA и SUPERNOVA: непрерывный поиск повреждающих и протективных факторов</article-title><trans-title-group xml:lang="en"><trans-title>EVA and SUPERNOVA concepts of vascular aging: ongoing research on damaging and protective risk factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5530-9772</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ротарь</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Rotar</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ротарь Оксана Петровна — доктор медицинских наук, главный научный сотрудник научно-исследовательской лаборатории эпидемиологии неинфекционных заболеваний Института сердца и сосудов.</p><p>Ул. Аккуратова, д. 2, Санкт-Петербург, 197341. Тел.: 8(812)702-37-56</p></bio><bio xml:lang="en"><p>Oxana Petrovna Rotar -MD, PhD, DSc, Head, Scientific Laboratory Epidemiology of Non-Communicable Diseases.</p><p>2 Akkuratov street, St Petersburg, 197341, Phone: 8(812)702-37-56</p></bio><email xlink:type="simple">rotari_oxana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2083-0947</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толкунова</surname><given-names>К. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolkunova</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Толкунова Кристина Михайловна—клинический ординатор Института сердца и сосудов.</p><p>Ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Kristina Mikhailovna Tolkunova - MD, Postgraduate Student.</p><p>2 Akkuratov street, St Petersburg, 197341</p></bio><email xlink:type="simple">Kristimix@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>05</day><month>05</month><year>2020</year></pub-date><volume>26</volume><issue>2</issue><fpage>133</fpage><lpage>145</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ротарь О.П., Толкунова К.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ротарь О.П., Толкунова К.М.</copyright-holder><copyright-holder xml:lang="en">Rotar O.P., Tolkunova K.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1945">https://htn.almazovcentre.ru/jour/article/view/1945</self-uri><abstract><p>В вопросах профилактики кардиометаболических заболеваний мы чаще всего опираемся на понятия риска и болезни, а не возможности сохранения здоровья. Концепция «сосудистого возраста» разработана для оценки биологического состояния артерий и выражения сердечно-сосудистого риска в годах для лучшего понимания врачом и пациентом. Преждевременное старение сосудов (на английском early vascular aging (EVA) синдром) изучается более 10 лет в рамках определения оптимальных критериев диагностики и терапевтических подходов лечения. В 2019 году ведущие эксперты в области изучения сосудистой жесткости предложили противоположную концепцию супернормального сосудистого старения (SUPERNOVA), при которой у пациентов наблюдаются чрезвычайно низкие показатели сосудистой жесткости для их возраста и пола. В настоящем обзоре обсуждаются новые данные о факторах, которые ускоряют или замедляют сосудистое старение.</p></abstract><trans-abstract xml:lang="en"><p>Regarding prevention of cardiometabolic diseases, we often rely on the concepts of risk and disease, rather than the possibility of prevention. The concept of “vascular age” is developed to assess the biological state of arteries and to present cardiovascular risk in years for better understanding by the doctor and patient. Early vascular aging (EVA) syndrome has been studied for more than 10 years to determine the optimal diagnostic criteria and treatment approaches. In 2019, leading experts in the area of vascular stiffness suggested the opposite concept of supernomal vascular aging (SUPERNOVA), in which patients have extremely low vascular stiffness rates for their age and gender. This review discusses new data about factors that accelerate or slow vascular aging.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сосудистая жесткость</kwd><kwd>раннее сосудистое старение</kwd><kwd>супернормальное сосудистое старение</kwd><kwd>артериальная гипертензия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial stiffness</kwd><kwd>SUPERNOVA</kwd><kwd>EVA</kwd><kwd>hypertension</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Koopman JJE, Kuipers RS. From arterial ageing to cardiovascular disease. Lancet. 2017;389(10080):1676-1678. doi:10.1016/S0140-6736(17)30763-8</mixed-citation><mixed-citation xml:lang="en">Koopman JJE, Kuipers RS. From arterial ageing to cardiovascular disease. Lancet. 2017;389(10080):1676-1678. doi:10.1016/S0140-6736(17)30763-8</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Groenewegen KA, den Ruijter HM, Pasterkamp G, Polak JF, Bots ML, Peters SA. Vascular age to determine cardiovascular disease risk: a systematic review of its concepts, definitions, and clinical applications. Eur J Prev Cardiol. 2016;23(3):264-274. doi:10.1177/2047487314566999</mixed-citation><mixed-citation xml:lang="en">Groenewegen KA, den Ruijter HM, Pasterkamp G, Polak JF, Bots ML, Peters SA. Vascular age to determine cardiovascular disease risk: a systematic review of its concepts, definitions, and clinical applications. Eur J Prev Cardiol. 2016;23(3):264-274. doi:10.1177/2047487314566999</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ротарь О. П., Алиева А. С., Бояринова М. А., Толкунова К. М., Конради А. О. Концепция сосудистого возраста: какой инструмент для оценки выбрать в клинической практике? Кардиология. 2019;59(2):45-53. doi:10.18087/cardio.2019.2.10229</mixed-citation><mixed-citation xml:lang="en">Rotar OP, AlievaAS, Boiarinova MA, Tolkunova KM, Konradi AO. Vascular age concept: which approach is preferable in clinical practice? Kardiologiia. 2019;59(2):45-53. doi:10.18087/cardio.2019.2.10229. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Солдатенкова Н. А., Орлов А. В., Ротарь О. П., Алиева А. С., Бояринова М. А., Могучая Е. В. и др. Раннее сосудистое старение: распространенность и предикторы в российской популяции. Биотехносфера. 2016;2(44):22-28.</mixed-citation><mixed-citation xml:lang="en">Soldatenkova NA, Orlov AV, Rotar OP, Alieva AS, Boyarinova MA, Moguchaya EV еt al. Early vascular aging: search of a method of an assessment. Biotekhnosfera. 2016;2(44):22-28. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнов А. Г., Ноздрин А. В., Шавгулидзе К. Б., Ток-мин Д. С., Осадчий И. В. Различия паспортного и биологического (фактического) возраста в популяции российских пациентов, страдающих артериальной гипертензией (анализ регистра «ГИПЕРИОН»). Терапевтический архив. 2018;90(4):21-28. doi:10.26442/terarkh201890421-28</mixed-citation><mixed-citation xml:lang="en">Arutyunov AG, Nozdrin AV, Shavgulidze KB, Tokmin DS, Osadchiy IV Differences between passport and biological (actual) age in the population of Russian patients suffering from arterial hypertension (analysis of the “Hyperion” register). Ter Arkh. 2018;90(4):21-28. doi:10.26442/terarkh201890421-28. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Laurent S, Boutouyrie P, Cunha PG, Lacolley P, Nilsson PM. Concept of extremes in vascular aging. From early vascular aging to supernormal vascular aging. Hypertension. 2019;74(2):218-228. doi:10.1161/HYPERTENSIONAHA.n9.12655</mixed-citation><mixed-citation xml:lang="en">Laurent S, Boutouyrie P, Cunha PG, Lacolley P, Nilsson PM. Concept of extremes in vascular aging. From early vascular aging to supernormal vascular aging. Hypertension. 2019;74(2):218-228. doi:10.1161/HYPERTENSIONAHA.n9.12655</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenberg DT. An evolutionary review of human telomere biology: the trifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Human Biol. 2011;23(2):149—167. doi:10.1002/ajhb.21127</mixed-citation><mixed-citation xml:lang="en">Eisenberg DT. An evolutionary review of human telomere biology: the trifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Human Biol. 2011;23(2):149—167. doi:10.1002/ajhb.21127</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson PM, Tufvesson H, Leosdottir M, Melander O. Telomeres and cardiovascular disease risk: an update 2013. Translat Res. 2013;162(6):371-380. doi:10.1016/j.trsl.2013.05.004</mixed-citation><mixed-citation xml:lang="en">Nilsson PM, Tufvesson H, Leosdottir M, Melander O. Telomeres and cardiovascular disease risk: an update 2013. Translat Res. 2013;162(6):371-380. doi:10.1016/j.trsl.2013.05.004</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Laganovic M, Bendix L, Rubelj I, Kirhmajer MV, Slade N, Lela IV at al. Reduced telomere length is not associated with early signs of vascular aging in young men born after intrauterine growth restriction: a paradox? J Hypertens. 2014;32(8):1613-1620. doi:10.1097/HJH.0000000000000217</mixed-citation><mixed-citation xml:lang="en">Laganovic M, Bendix L, Rubelj I, Kirhmajer MV, Slade N, Lela IV at al. Reduced telomere length is not associated with early signs of vascular aging in young men born after intrauterine growth restriction: a paradox? J Hypertens. 2014;32(8):1613-1620. doi:10.1097/HJH.0000000000000217</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Arnoult N, Van Beneden A, Decottignies A. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1a. Nat Struct Mol Biol. 2012;19(9):948-956. doi:10.1038/nsmb.2364</mixed-citation><mixed-citation xml:lang="en">Arnoult N, Van Beneden A, Decottignies A. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1a. Nat Struct Mol Biol. 2012;19(9):948-956. doi:10.1038/nsmb.2364</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fyhrquist F, Saijonmaa O. Telomere length and cardiovascular aging. Ann Med. 2012;44(1):138-142. doi:10.3109/07853890.2012.660497</mixed-citation><mixed-citation xml:lang="en">Fyhrquist F, Saijonmaa O. Telomere length and cardiovascular aging. Ann Med. 2012;44(1):138-142. doi:10.3109/07853890.2012.660497</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Masi S, D’Aiuto F, Martin-Ruiz C, Kahn T, Wong A, Ghosh AK et al. Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. Eur Heart J. 2014;35(46):3296-3303. doi:10.1093/eurheartj/ehu226</mixed-citation><mixed-citation xml:lang="en">Masi S, D’Aiuto F, Martin-Ruiz C, Kahn T, Wong A, Ghosh AK et al. Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. Eur Heart J. 2014;35(46):3296-3303. doi:10.1093/eurheartj/ehu226</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">McDonnell BJ, Maki-Petaja KM, Munnery M, Yasmin, Wilkinson IB, Cockcroft JR et al. Habitual exercise and blood pressure: age dependency and underlying mechanisms. Am J Hypertens. 2013;26(3):334-341. doi:10.1093/ajh/hps055</mixed-citation><mixed-citation xml:lang="en">McDonnell BJ, Maki-Petaja KM, Munnery M, Yasmin, Wilkinson IB, Cockcroft JR et al. Habitual exercise and blood pressure: age dependency and underlying mechanisms. Am J Hypertens. 2013;26(3):334-341. doi:10.1093/ajh/hps055</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mangino M, Cecelja M, Menni C, Tsai PC, Yuan W, Small K et al. Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity. J Hypertens. 2016;34(1):79-87. doi:10.1097/HJH.0000000000000732</mixed-citation><mixed-citation xml:lang="en">Mangino M, Cecelja M, Menni C, Tsai PC, Yuan W, Small K et al. Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity. J Hypertens. 2016;34(1):79-87. doi:10.1097/HJH.0000000000000732</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Herrera VL, Decano JL, Giordano N, Moran AM, Ruiz-Opazo N. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats. PLoS One. 2014;9(9):e107888. doi:10.1371/journal.pone.0107888</mixed-citation><mixed-citation xml:lang="en">Herrera VL, Decano JL, Giordano N, Moran AM, Ruiz-Opazo N. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats. PLoS One. 2014;9(9):e107888. doi:10.1371/journal.pone.0107888</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS et al. SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. Aging Cell. 2014;13(5):890-899. doi:10.1111/acel.12247</mixed-citation><mixed-citation xml:lang="en">Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS et al. SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. Aging Cell. 2014;13(5):890-899. doi:10.1111/acel.12247</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A et al. Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circ Res. 2017;120(2):296-311. doi:10.1161/CIRCRESAHA.116.309322</mixed-citation><mixed-citation xml:lang="en">Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A et al. Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circ Res. 2017;120(2):296-311. doi:10.1161/CIRCRESAHA.116.309322</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Koivistoinen T, Hutri-Kahonen N, Juonala M, Aatola H, Koobi T, Lehtimaki T et al. Metabolic syndrome inchildhood and increased arterial stiffness in adulthood: the Cardiovascular Risk In Young Finns Study. Ann Med. 2011;43(4):312-319. doi:10.3109/07853890.2010.549145</mixed-citation><mixed-citation xml:lang="en">Koivistoinen T, Hutri-Kahonen N, Juonala M, Aatola H, Koobi T, Lehtimaki T et al. Metabolic syndrome inchildhood and increased arterial stiffness in adulthood: the Cardiovascular Risk In Young Finns Study. Ann Med. 2011;43(4):312-319. doi:10.3109/07853890.2010.549145</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ et al. Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circ Res. 2010;107(1):117-125. doi:10.1161/CIRCRESAHA.109.215228</mixed-citation><mixed-citation xml:lang="en">Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ et al. Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circ Res. 2010;107(1):117-125. doi:10.1161/CIRCRESAHA.109.215228</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lees JS, Chapman FA, Witham MD, Jardine AG, Mark PB. Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart. 2019;105(12):938-945. doi:10.1136/heartjnl-2018-313955</mixed-citation><mixed-citation xml:lang="en">Lees JS, Chapman FA, Witham MD, Jardine AG, Mark PB. Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart. 2019;105(12):938-945. doi:10.1136/heartjnl-2018-313955</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chen HG, Sheng LT, ZhangYB, CaoAL, Lai YW, Kunutsor SK et al. Association of vitamin K with cardiovascular events and allcause mortality: a systematic review and meta-analysis. Eur J Nutr. 2019;58(6):2191-2205. doi: 10.1007/s00394-019-01998-3</mixed-citation><mixed-citation xml:lang="en">Chen HG, Sheng LT, ZhangYB, CaoAL, Lai YW, Kunutsor SK et al. Association of vitamin K with cardiovascular events and allcause mortality: a systematic review and meta-analysis. Eur J Nutr. 2019;58(6):2191-2205. doi: 10.1007/s00394-019-01998-3</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Caesar R, Fak F, Backhed F. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. J Intern Med. 2010;268(4):320-328. doi:10.1111/j.1365-2796.2010.02270.x</mixed-citation><mixed-citation xml:lang="en">Caesar R, Fak F, Backhed F. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. J Intern Med. 2010;268(4):320-328. doi:10.1111/j.1365-2796.2010.02270.x</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Menni C, Lin C, CeceljaM, Mangino M, Matey-Hemandez ML, Keehn L et al. Gut microbial diversity is associated with lower arterial stiffness in women. Eur Heart J. 2018;39(25):2390-2397. doi:10.1093/eurheartj/ehy226</mixed-citation><mixed-citation xml:lang="en">Menni C, Lin C, CeceljaM, Mangino M, Matey-Hemandez ML, Keehn L et al. Gut microbial diversity is associated with lower arterial stiffness in women. Eur Heart J. 2018;39(25):2390-2397. doi:10.1093/eurheartj/ehy226</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Boutagy NE, McMillan RP, Frisard MI, Hulver MW. Metabolic endotoxemia with obesity: is it real and is it relevant? Biochimie. 2016;124:11-20. doi:10.1016/j.biochi.2015.06.020</mixed-citation><mixed-citation xml:lang="en">Boutagy NE, McMillan RP, Frisard MI, Hulver MW. Metabolic endotoxemia with obesity: is it real and is it relevant? Biochimie. 2016;124:11-20. doi:10.1016/j.biochi.2015.06.020</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Caricilli AM, Saad MJ. Gut microbiota composition and its effects on obesity and insulin resistance. Curr Opin Clin Nutr Metab Care. 2014;17(4):312-318. doi:10.1097/MC0.0000000000000067</mixed-citation><mixed-citation xml:lang="en">Caricilli AM, Saad MJ. Gut microbiota composition and its effects on obesity and insulin resistance. Curr Opin Clin Nutr Metab Care. 2014;17(4):312-318. doi:10.1097/MC0.0000000000000067</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka H, Palta P, Folsom AR, Meyer ML, Matsushita K, Evenson KR et al. Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study. J Hypertens. 2018;36(9):1889-1894. doi:10.1097/HJH.0000000000001782</mixed-citation><mixed-citation xml:lang="en">Tanaka H, Palta P, Folsom AR, Meyer ML, Matsushita K, Evenson KR et al. Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study. J Hypertens. 2018;36(9):1889-1894. doi:10.1097/HJH.0000000000001782</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Wong A, Kwak YS, Scott SD, Pekas EJ, Son WM, Kim JS et al. The effects of swimming training on arterial function, muscular strength, and cardiorespiratory capacity in postmenopausal women with stage 2 hypertension. Menopause. 2018;26(6):653-658. doi: 10.1097/GME.0000000000001288</mixed-citation><mixed-citation xml:lang="en">Wong A, Kwak YS, Scott SD, Pekas EJ, Son WM, Kim JS et al. The effects of swimming training on arterial function, muscular strength, and cardiorespiratory capacity in postmenopausal women with stage 2 hypertension. Menopause. 2018;26(6):653-658. doi: 10.1097/GME.0000000000001288</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fleenor BS, Marshall KD, Durrant JR, Lesniewski LA, Seals DR. Arterial stiffening with ageing is associated with transforming growth factor-P1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol. 2010;588(20):3971-3982. doi:10.n13/jphysiol.2010.194753</mixed-citation><mixed-citation xml:lang="en">Fleenor BS, Marshall KD, Durrant JR, Lesniewski LA, Seals DR. Arterial stiffening with ageing is associated with transforming growth factor-P1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol. 2010;588(20):3971-3982. doi:10.n13/jphysiol.2010.194753</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shibata S, Fujimoto N, Hastings JL, Carrick-Ranson G, Bhella PS, Hearon CM et al. The effect of lifelong exercise frequency on arterial stiffness. J Physiol. 2018;596(14):2783-2795. doi:10.n13/JP275301</mixed-citation><mixed-citation xml:lang="en">Shibata S, Fujimoto N, Hastings JL, Carrick-Ranson G, Bhella PS, Hearon CM et al. The effect of lifelong exercise frequency on arterial stiffness. J Physiol. 2018;596(14):2783-2795. doi:10.n13/JP275301</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brozovich FV, Nicholson CJ, Degen CV, Gao YZ, Aggarwal M, Morgan KG. Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. Pharmacol Rev. 2016;68(2):476-532. doi:10.1124/pr.115.010652</mixed-citation><mixed-citation xml:lang="en">Brozovich FV, Nicholson CJ, Degen CV, Gao YZ, Aggarwal M, Morgan KG. Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders. Pharmacol Rev. 2016;68(2):476-532. doi:10.1124/pr.115.010652</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Okamoto T, Masuhara M, Ikuta K. Upper but not lower limb resistance training increases arterial stiffness in humans. Eur J Appl Physiol. 2009;107(2):127-134. doi:10.1007/s00421-009-1110-x</mixed-citation><mixed-citation xml:lang="en">Okamoto T, Masuhara M, Ikuta K. Upper but not lower limb resistance training increases arterial stiffness in humans. Eur J Appl Physiol. 2009;107(2):127-134. doi:10.1007/s00421-009-1110-x</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI et al. Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Am J Hypertens. 2016;29(4):494-500. doi:10.1093/ajh/hpv139</mixed-citation><mixed-citation xml:lang="en">Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI et al. Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Am J Hypertens. 2016;29(4):494-500. doi:10.1093/ajh/hpv139</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Figueroa A, Park SY, Seo DY, Sanchez-Gonzalez MA, Baek YH. Combined resistance and endurance exercise training improves arterial stiffness, blood pressure, and muscle strength in postmenopausal women. Menopause. 2011;18(9):980-984. doi:10.1097/gme.0b013e3182135442</mixed-citation><mixed-citation xml:lang="en">Figueroa A, Park SY, Seo DY, Sanchez-Gonzalez MA, Baek YH. Combined resistance and endurance exercise training improves arterial stiffness, blood pressure, and muscle strength in postmenopausal women. Menopause. 2011;18(9):980-984. doi:10.1097/gme.0b013e3182135442</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N et al. Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women. Am J Physiol Heart Circ Physiol. 2009;297(5): 1899-1903. doi:10.1152/ajpheart.00433.2009</mixed-citation><mixed-citation xml:lang="en">Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N et al. Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women. Am J Physiol Heart Circ Physiol. 2009;297(5): 1899-1903. doi:10.1152/ajpheart.00433.2009</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Park W, Miyachi M, Tanaka H. Does aerobic exercise mitigate the effects of cigarette smoking on arterial stiffness? J Clin Hypertens (Greenwich). 2014;16(9):640-4. doi: 10.1111/jch.12385</mixed-citation><mixed-citation xml:lang="en">Park W, Miyachi M, Tanaka H. Does aerobic exercise mitigate the effects of cigarette smoking on arterial stiffness? J Clin Hypertens (Greenwich). 2014;16(9):640-4. doi: 10.1111/jch.12385</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">George J, Hussain M, Vadiveloo T, Ireland S, Hopkinson P, Struthers AD et al. Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes. J Am Coll Cardiol. 2019;74(25):3112-3120. doi:10.1016/j.jacc.2019.09.067</mixed-citation><mixed-citation xml:lang="en">George J, Hussain M, Vadiveloo T, Ireland S, Hopkinson P, Struthers AD et al. Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes. J Am Coll Cardiol. 2019;74(25):3112-3120. doi:10.1016/j.jacc.2019.09.067</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Franzen KF, Willig J, Cayo Talavera S, Meusel M, Sayk F, Reppel M et al. E-cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: A randomized, double-blinded pilot study. Vasc Med. 2018;23(5):419-425. doi:10. 1177/1358863X18779694</mixed-citation><mixed-citation xml:lang="en">Franzen KF, Willig J, Cayo Talavera S, Meusel M, Sayk F, Reppel M et al. E-cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: A randomized, double-blinded pilot study. Vasc Med. 2018;23(5):419-425. doi:10. 1177/1358863X18779694</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Cossio R, Cerra ZA, Tanaka H. Vascular effects of a single bout of electronic cigarette use. Clin Exp Pharmacol Physiol. 2020;47(1):3-6. doi: 10.1111/1440-1681.13180</mixed-citation><mixed-citation xml:lang="en">Cossio R, Cerra ZA, Tanaka H. Vascular effects of a single bout of electronic cigarette use. Clin Exp Pharmacol Physiol. 2020;47(1):3-6. doi: 10.1111/1440-1681.13180</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Caporale A, Langham MC, Guo W, JohncolaA, Chatterjee S, Wehrli FW. Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI. Radiology. 2019;293(1):97-106. doi:10.1148/radiol.2019190562</mixed-citation><mixed-citation xml:lang="en">Caporale A, Langham MC, Guo W, JohncolaA, Chatterjee S, Wehrli FW. Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI. Radiology. 2019;293(1):97-106. doi:10.1148/radiol.2019190562</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Xue C, Chen QZ, Bian L, Yin ZF, Xu ZJ, Zhang AL et al. Effects of smoking cessation with nicotine replacement therapy on vascular endothelial function, arterial stiffness, and inflammation response in healthy smokers. Angiology. 2019;70(8):719-725. doi:10.1177/0003319719853458</mixed-citation><mixed-citation xml:lang="en">Xue C, Chen QZ, Bian L, Yin ZF, Xu ZJ, Zhang AL et al. Effects of smoking cessation with nicotine replacement therapy on vascular endothelial function, arterial stiffness, and inflammation response in healthy smokers. Angiology. 2019;70(8):719-725. doi:10.1177/0003319719853458</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Rezk-Hanna M, Doering L, Robbins W, Sarna L, ElashoffRM, Victor RG. Acute effect of hookah smoking on arterial stiffness and wave reflections in adults aged 18 to 34 years of age. Am J Cardiol. 2018;122(5):905-909. doi:10.1016/j.amjcard.2018.05.033</mixed-citation><mixed-citation xml:lang="en">Rezk-Hanna M, Doering L, Robbins W, Sarna L, ElashoffRM, Victor RG. Acute effect of hookah smoking on arterial stiffness and wave reflections in adults aged 18 to 34 years of age. Am J Cardiol. 2018;122(5):905-909. doi:10.1016/j.amjcard.2018.05.033</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Charakida M, Georgiopoulos G, Dangardt F, Chiesa ST, Hughes AD, Rapala A et al. Early vasculardamage from smoking and alcohol in teenage years: the ALSPAC study. Eur Heart J. 2019;21;40(4):345-353. doi:10.1093/eurheartj/ehy524</mixed-citation><mixed-citation xml:lang="en">Charakida M, Georgiopoulos G, Dangardt F, Chiesa ST, Hughes AD, Rapala A et al. Early vasculardamage from smoking and alcohol in teenage years: the ALSPAC study. Eur Heart J. 2019;21;40(4):345-353. doi:10.1093/eurheartj/ehy524</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Juonala M, Viikari JSA, Kahonen M, Laitinen T, Taittonen L, Loo B-M et al. Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study. Atherosclerosis 2009;204:e93-e98.</mixed-citation><mixed-citation xml:lang="en">Juonala M, Viikari JSA, Kahonen M, Laitinen T, Taittonen L, Loo B-M et al. Alcohol consumption is directly associated with carotid intima-media thickness in Finnish young adults: the Cardiovascular Risk in Young Finns Study. Atherosclerosis 2009;204:e93-e98.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang CL, Piano MR, Thur LA, Peters TA, da Silva ALG, Phillips SA. The effectsrepeated binge drinking on arterial stiffness and norepinephrine levels in young adults. J Hypertens. 2020; 38(1):111-117. doi:10.1097/HJH.0000000000002223</mixed-citation><mixed-citation xml:lang="en">Hwang CL, Piano MR, Thur LA, Peters TA, da Silva ALG, Phillips SA. The effectsrepeated binge drinking on arterial stiffness and norepinephrine levels in young adults. J Hypertens. 2020; 38(1):111-117. doi:10.1097/HJH.0000000000002223</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Agabiti-Rosei C, Favero G, De Ciuceis C, Rossini C, Porteri E, Rodella LF et al. Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice. Hypertens Res. 2017;40(1):41-50. doi:10.1038/hr.2016.103</mixed-citation><mixed-citation xml:lang="en">Agabiti-Rosei C, Favero G, De Ciuceis C, Rossini C, Porteri E, Rodella LF et al. Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice. Hypertens Res. 2017;40(1):41-50. doi:10.1038/hr.2016.103</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Lee FY, Sun CK, Sung PH, Chen KH, Chua S, Sheu JJ et al. Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice. J Pineal Res. 2018;65(2): e12489. doi:10.1111/jpi.12489</mixed-citation><mixed-citation xml:lang="en">Lee FY, Sun CK, Sung PH, Chen KH, Chua S, Sheu JJ et al. Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice. J Pineal Res. 2018;65(2): e12489. doi:10.1111/jpi.12489</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Грищенко О. О., Бродовская Т. О., Гришина И. Ф, Пере-толчина Т. Ф. Особенности ремоделирования сонных артерий у пациентов с синдромом обструктивного апноэ сна в контексте концепции раннего старения. Практическая медицина. 2019;2(17):84-88.</mixed-citation><mixed-citation xml:lang="en">Grishchenko OO, Brodovskaya TO, Grishina IF, Peretolchina TF. Features of carotid artery remodeling in patients with obstructive sleep apnea syndrome in the context of the concept of early aging. Practical Medicine 2019;2(17):84-88. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Qortuk M, Akyol S, Baykan AO, Kiraz K, Ufar H, Qayli M et al. Aortic stiffness increases in proportion to the severity of apnoea-hypopnea index in patients with obstructive sleep apnoea syndrome. Clin Respir J. 2016;10(4):455-61. doi:10.1111/crj.12244</mixed-citation><mixed-citation xml:lang="en">Qortuk M, Akyol S, Baykan AO, Kiraz K, Ufar H, Qayli M et al. Aortic stiffness increases in proportion to the severity of apnoea-hypopnea index in patients with obstructive sleep apnoea syndrome. Clin Respir J. 2016;10(4):455-61. doi:10.1111/crj.12244</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Air pollution [Electronic resource]. World Health Organization, 2015 [cited 2019 Oct 19]. Available from:who.int/airpollution/data/en</mixed-citation><mixed-citation xml:lang="en">WHO Air pollution [Electronic resource]. World Health Organization, 2015 [cited 2019 Oct 19]. Available from:who.int/airpollution/data/en</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lundback M, Mills NL, Lucking A, Barath S, Donaldson K, Newby DE et al. Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol. 2009;6:7. doi:10.1186/1743-8977-6-7</mixed-citation><mixed-citation xml:lang="en">Lundback M, Mills NL, Lucking A, Barath S, Donaldson K, Newby DE et al. Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol. 2009;6:7. doi:10.1186/1743-8977-6-7</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Wu CF, Shen FH, Li YR, Tsao TM, Tsai MJ, Chen CC et al. Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects. Sci Total Environ. 2016;569-570:300-305. doi:10.1016/j.scitotenv.2016.06.084</mixed-citation><mixed-citation xml:lang="en">Wu CF, Shen FH, Li YR, Tsao TM, Tsai MJ, Chen CC et al. Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects. Sci Total Environ. 2016;569-570:300-305. doi:10.1016/j.scitotenv.2016.06.084</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Tamagawa E, Bai N, Morimoto K, Gray C, Mui T, Yatera K et al. Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am J Physiol Lung Cell Mol Physiol. 2008;295(1):79-85. doi:10.1152/ajplung.00048.2007</mixed-citation><mixed-citation xml:lang="en">Tamagawa E, Bai N, Morimoto K, Gray C, Mui T, Yatera K et al. Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am J Physiol Lung Cell Mol Physiol. 2008;295(1):79-85. doi:10.1152/ajplung.00048.2007</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Thurston GD, Newman JD. Walking to a pathway for cardiovascular effects of air pollution. Lancet. 2018;391(10118):291-292. doi:10.1016/S 0140-6736(17)33078-7</mixed-citation><mixed-citation xml:lang="en">Thurston GD, Newman JD. Walking to a pathway for cardiovascular effects of air pollution. Lancet. 2018;391(10118):291-292. doi:10.1016/S 0140-6736(17)33078-7</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Burden of disease from environmental noise [Internet]. World Health Organization; 2011 [cited 2019 Oct 19] Available from: http://www.euro.who.int/__data/assets/pdf_file/0008/136466/e94888.pdf</mixed-citation><mixed-citation xml:lang="en">WHO Burden of disease from environmental noise [Internet]. World Health Organization; 2011 [cited 2019 Oct 19] Available from: http://www.euro.who.int/__data/assets/pdf_file/0008/136466/e94888.pdf</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Basner M, Muller U, Elmenhorst EM. Single and combined effects of air, road, and rail traffic noise on sleep and recuperation. Sleep. 2011;34:11-23</mixed-citation><mixed-citation xml:lang="en">Basner M, Muller U, Elmenhorst EM. Single and combined effects of air, road, and rail traffic noise on sleep and recuperation. Sleep. 2011;34:11-23</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt FP, Basner M, Kroger G, Weck S, Schnorbus B, Muttray A et al. Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults. Eur Heart J. 2013;34(45):3508-14a. doi:10.1093/eurheartj/eht269</mixed-citation><mixed-citation xml:lang="en">Schmidt FP, Basner M, Kroger G, Weck S, Schnorbus B, Muttray A et al. Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults. Eur Heart J. 2013;34(45):3508-14a. doi:10.1093/eurheartj/eht269</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Rojek M, Rajzer MW, Wojciechowska W, Drozdz T, Skalski P, Pizon T et al. Relationship among long-term aircraftnoiseexposure, bloodpressureprofile, and arterialstiffness. J Hypertens. 2019;37(7):1350-1358. doi: 10.1097/HJH.0000000000002060</mixed-citation><mixed-citation xml:lang="en">Rojek M, Rajzer MW, Wojciechowska W, Drozdz T, Skalski P, Pizon T et al. Relationship among long-term aircraftnoiseexposure, bloodpressureprofile, and arterialstiffness. J Hypertens. 2019;37(7):1350-1358. doi: 10.1097/HJH.0000000000002060</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Liberale L, Montecucco F, Tardif JC, Libby P, Camici GG. Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 2020;1-14. doi:10.1093/eurheartj/ehz961</mixed-citation><mixed-citation xml:lang="en">Liberale L, Montecucco F, Tardif JC, Libby P, Camici GG. Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 2020;1-14. doi:10.1093/eurheartj/ehz961</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Marchesi C, Ebrahimian T, Angulo O, Paradis P, Schiffrin EL. Endothelial NO synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension. 2009;54(6):1384-1392. doi: 10.1161/HYPERTENSIONAHA.109.138305</mixed-citation><mixed-citation xml:lang="en">Marchesi C, Ebrahimian T, Angulo O, Paradis P, Schiffrin EL. Endothelial NO synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension. 2009;54(6):1384-1392. doi: 10.1161/HYPERTENSIONAHA.109.138305</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Schiffrin EL. T Lynphocytes: a role in hypertension? Curr Opin Nephrol Hypertens. 2010;19(2):181-186. doi:10.1097/MNH.0b013e3283360a2e</mixed-citation><mixed-citation xml:lang="en">Schiffrin EL. T Lynphocytes: a role in hypertension? Curr Opin Nephrol Hypertens. 2010;19(2):181-186. doi:10.1097/MNH.0b013e3283360a2e</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Harbord M, Annese V, Vavricka SR, Allez M, Barreiro-de Acosta M, Boberg KM et al. The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease. J Crohns Colitis. 2016;10(3):239-254. doi:10.1093/ecco-jcc/jjv213</mixed-citation><mixed-citation xml:lang="en">Harbord M, Annese V, Vavricka SR, Allez M, Barreiro-de Acosta M, Boberg KM et al. The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease. J Crohns Colitis. 2016;10(3):239-254. doi:10.1093/ecco-jcc/jjv213</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Zanoli L, Inserra G, Castellino P. Increased cardiovascular risk in subjects with a low prevalence of classic cardiovascular risk factors: the inflammatory bowel disease paradox. Trends Cardiovasc Med. 2015;25(8):705-706. doi:10.1016/j.tcm.2015.04.001</mixed-citation><mixed-citation xml:lang="en">Zanoli L, Inserra G, Castellino P. Increased cardiovascular risk in subjects with a low prevalence of classic cardiovascular risk factors: the inflammatory bowel disease paradox. Trends Cardiovasc Med. 2015;25(8):705-706. doi:10.1016/j.tcm.2015.04.001</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Zanoli L, Boutouyrie P, Fatuzzo P, Granata A, Lentini P, Ozturk K et al. Inflammation and aortic stiffness: an individual participant data meta-analysis in patients with inflammatory bowel disease. J Am Heart Assoc. 2017;6(10): e007003. doi: 10.1161/JAHA.117.007003</mixed-citation><mixed-citation xml:lang="en">Zanoli L, Boutouyrie P, Fatuzzo P, Granata A, Lentini P, Ozturk K et al. Inflammation and aortic stiffness: an individual participant data meta-analysis in patients with inflammatory bowel disease. J Am Heart Assoc. 2017;6(10): e007003. doi: 10.1161/JAHA.117.007003</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Ben-Shlomo Y, Spears M, Boustred C, May M,Anderson SG, Benjamin EJ et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17635 subjects. J Am Coll Cardiol. 2014;63(7):636-646. doi:10.1016/j.jacc.2013.09.063</mixed-citation><mixed-citation xml:lang="en">Ben-Shlomo Y, Spears M, Boustred C, May M,Anderson SG, Benjamin EJ et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17635 subjects. J Am Coll Cardiol. 2014;63(7):636-646. doi:10.1016/j.jacc.2013.09.063</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Ikonomidis I, Makavos G, Papadavid E, Varoudi M, Andreadou I, Gravanis K et al. Similarities in coronary function and myocardial deformation between psoriasis and coronary artery disease: the role of oxidative stress and inflammation. Can J Cardiol. 2015;31(3):287-295. doi:10.1016/j.cjca.2014.11.002</mixed-citation><mixed-citation xml:lang="en">Ikonomidis I, Makavos G, Papadavid E, Varoudi M, Andreadou I, Gravanis K et al. Similarities in coronary function and myocardial deformation between psoriasis and coronary artery disease: the role of oxidative stress and inflammation. Can J Cardiol. 2015;31(3):287-295. doi:10.1016/j.cjca.2014.11.002</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Ikonomidis I, Papadavid E, Makavos G, Andreadou I, Varoudi M, Gravanis K et al. Lowering interleukin-12 activity improves myocardial and vascular function compared with tumor necrosis factor-a antagonism or cyclosporine in psoriasis. Circ Cardiovasc Imaging. 2017;10(9):e006283. doi: 10.1161/CIRCIMAGING.117.006283</mixed-citation><mixed-citation xml:lang="en">Ikonomidis I, Papadavid E, Makavos G, Andreadou I, Varoudi M, Gravanis K et al. Lowering interleukin-12 activity improves myocardial and vascular function compared with tumor necrosis factor-a antagonism or cyclosporine in psoriasis. Circ Cardiovasc Imaging. 2017;10(9):e006283. doi: 10.1161/CIRCIMAGING.117.006283</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Roifman I, Beck PL, Anderson TJ, Eisenberg MJ, Genest J. Chronic inflammatory diseases and cardiovascular risk: a systematic review. Can J Cardiol. 2011;27(2):174-182. doi:10.1016/j.cjca.2010.12.040</mixed-citation><mixed-citation xml:lang="en">Roifman I, Beck PL, Anderson TJ, Eisenberg MJ, Genest J. Chronic inflammatory diseases and cardiovascular risk: a systematic review. Can J Cardiol. 2011;27(2):174-182. doi:10.1016/j.cjca.2010.12.040</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Маслянский А. Л., Пенин И. Н., Чешуина М. Д., Триши-на И. Н., Новикова А. Н., Колесова Е. П. и др. Общие закономерности продукции цитокинов и хемокинов у больных диффузными заболеваниями соединительной ткани, воспалительными артропатиями и атеросклерозом. Цитокины и воспаление. 2014;13(3):9-21.</mixed-citation><mixed-citation xml:lang="en">Maslyanskiy AL, Penin IN, Cheshuina MD, Trichina IN, Novikova AN, Kolesova EP et al. Common consistent patterns of the cytokine and chemokine production in patients with diffuse connective tissue diseases, inflammatory arthropathies and atherosclerosis. Cytokines and Inflammation. 2014;13(3):9-21. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Chen XM, Hu CP, Li YJ, Jiang JL. Cardiovascular risk in autoimmune disorders: role of asymmetric dimethylarginine. Eur J Pharmacol. 2012;696(1-3):5-11. doi:10.1016/j.ejphar.2012.09.019</mixed-citation><mixed-citation xml:lang="en">Chen XM, Hu CP, Li YJ, Jiang JL. Cardiovascular risk in autoimmune disorders: role of asymmetric dimethylarginine. Eur J Pharmacol. 2012;696(1-3):5-11. doi:10.1016/j.ejphar.2012.09.019</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Riccioni G, Bucciarelli V, Scotti L, Aceto A, D Orazio N, Di Ilio E et al. Relationship between asymmetric dimethylarginine and asymptomatic carotid atherosclerosis. J Biol Regul Homeost Agents. 2010;24(3):351-358.</mixed-citation><mixed-citation xml:lang="en">Riccioni G, Bucciarelli V, Scotti L, Aceto A, D Orazio N, Di Ilio E et al. Relationship between asymmetric dimethylarginine and asymptomatic carotid atherosclerosis. J Biol Regul Homeost Agents. 2010;24(3):351-358.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Zewinger S, Schumann T, Fliser D, Speer T. Innate immunity in CKD-associated vascular diseases. Nephrol Dial Transplant. 2016;31:1813-1821. doi:10.1093/ndt/gfv358</mixed-citation><mixed-citation xml:lang="en">Zewinger S, Schumann T, Fliser D, Speer T. Innate immunity in CKD-associated vascular diseases. Nephrol Dial Transplant. 2016;31:1813-1821. doi:10.1093/ndt/gfv358</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG et al. Inflammation and premature aging in advanced chronic kidney disease. Am J Physiol Renal Physiol. 2017;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017</mixed-citation><mixed-citation xml:lang="en">Kooman JP, Dekker MJ, Usvyat LA, Kotanko P, van der Sande FM, Schalkwijk CG et al. Inflammation and premature aging in advanced chronic kidney disease. Am J Physiol Renal Physiol. 2017;313(4):F938-F950. doi: 10.1152/ajprenal.00256.2017</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada S, Tokumoto M, Tsuruya K, Tatsumoto N, Noguchi H, Kitazono T et al. Fetuin-A decrease induced by a low-protein diet enhances vascular calcification in uremic rats with hyperphosphatemia. Am J Physiol Renal Physiol. 2015;309:744-754. doi:10.1152/ajprenal.00017.2015</mixed-citation><mixed-citation xml:lang="en">Yamada S, Tokumoto M, Tsuruya K, Tatsumoto N, Noguchi H, Kitazono T et al. Fetuin-A decrease induced by a low-protein diet enhances vascular calcification in uremic rats with hyperphosphatemia. Am J Physiol Renal Physiol. 2015;309:744-754. doi:10.1152/ajprenal.00017.2015</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Smith ER, Hanssen E, McMahon LP, Holt SG. Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage. PLoS One 2013;8(4): e60904. doi:10.1371/journal.pone.0060904</mixed-citation><mixed-citation xml:lang="en">Smith ER, Hanssen E, McMahon LP, Holt SG. Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage. PLoS One 2013;8(4): e60904. doi:10.1371/journal.pone.0060904</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
