<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2020-26-3-263-269</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-1951</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Изменения процесса оказания помощи пациентам с инсультом в условиях эпидемии COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Healthcare for stroke patients in COVID-19 pandemic</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6484-286X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янишевский</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yanishevskiy</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Янишевский Станислав Николаевич — доктор медицинских наук, доцент, заведующий научно-исследовательской лабораторией неврологии и нейрореабилитации</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Stanislav N. Yanishevskiy, MD, PhD, DSc, Associate Professor, Head, Research Laboratory for Neurology and Neurorehabilitation</p><p>2 Akkuratov street, St Petersburg, 197341</p></bio><email xlink:type="simple">yanishevskiy_sn@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>10</day><month>05</month><year>2020</year></pub-date><volume>26</volume><issue>3</issue><fpage>263</fpage><lpage>269</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Янишевский С.Н., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Янишевский С.Н.</copyright-holder><copyright-holder xml:lang="en">Yanishevskiy S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/1951">https://htn.almazovcentre.ru/jour/article/view/1951</self-uri><abstract><p>Эпидемия новой коронавирусной инфекции (COVID-19) внесла существенные изменения в ритм работы сосудистых отделений. Важной проблемой является сочетание инфекционного процесса и остро возникшей очаговой неврологической симптоматики. С одной стороны, изменения могут наблюдаться при развитии инсульта у пациента с респираторной вирусной инфекцией, с другой стороны, такая симптоматика может быть характерна для прямого поражения головного мозга при вирусной инфекции. Поражения центральной нервной системы при коронавирусе включают развитие энцефалита, инфекционно-токсической энцефалопатии с многообразными проявлениями — от головной боли до нарушений сознания при тяжелом течении инфекции. Это требует дополнительных подходов для правильной постановки диагноза и изменения протоколов ведения пациентов с неврологической симптоматикой. В статье рассматриваются основные вопросы и сложности, связанные с оказанием медицинской помощи пациентам с признаками поражения центральной нервной системы в условиях коронавирусной пандемии.</p></abstract><trans-abstract xml:lang="en"><p>COVID-19 pandemic changed the setup of vascular centers. The co-existence of coronaviral infection and neurological symptoms is an important issue. On the one hand, neurological manifestations can result from acute stroke in a patient afflicted with SARS-CoV-2. On the other hand, they can be caused by the direct brain viral damage. Coronavirus damage of central neural system includes encephalitis and infection-related toxic encephalopathy. The latter can present with various manifestations (from headache to conscious disorders in severe cases). Therefore, additional diagnostic approaches and new treatment protocols are required. The paper covers important issues related to healthcare delivery for patients with neurologic symptoms in COVID-19 pandemic.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инсульт</kwd><kwd>неврологические осложнения</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>маршрутизация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke</kwd><kwd>neurological complications</kwd><kwd>novel coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>patient routing</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Desforges M, le Coupanec A, Stodola JK, Meessen-Pinard M, Talbot PJ. Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis. Virus Res. 2014;194:145–158. doi:10.1016/j.virusres.2014.09.011</mixed-citation><mixed-citation xml:lang="en">Desforges M, le Coupanec A, Stodola JK, Meessen-Pinard M, Talbot PJ. Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis. Virus Res. 2014;194:145–158. doi:10.1016/j.virusres.2014.09.011</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386. doi:10.3389/fncel.2018.00386</mixed-citation><mixed-citation xml:lang="en">Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386. doi:10.3389/fncel.2018.00386</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways, J Pathol. 2004;203(2):622–630.</mixed-citation><mixed-citation xml:lang="en">Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways, J Pathol. 2004;203(2):622–630.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92(6):552-555. doi:10.1002/jmv.25728</mixed-citation><mixed-citation xml:lang="en">Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92(6):552-555. doi:10.1002/jmv.25728</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020. [Ahead of print, published online 30 March 2020]. doi.org/10.1016/j.bbi.2020.03.031</mixed-citation><mixed-citation xml:lang="en">Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020. [Ahead of print, published online 30 March 2020]. doi.org/10.1016/j.bbi.2020.03.031</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Moriguchi Т, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Intern J Infectious Dis. 2020;94:55–58. doi.org/10.1016/j.ijid.2020.03.062</mixed-citation><mixed-citation xml:lang="en">Moriguchi Т, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Intern J Infectious Dis. 2020;94:55–58. doi.org/10.1016/j.ijid.2020.03.062</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI Features. Radiology. 2020;201187. doi:10.1148/radiol.2020201187</mixed-citation><mixed-citation xml:lang="en">Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI Features. Radiology. 2020;201187. doi:10.1148/radiol.2020201187</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mao L, Wang M, Chen S, He Q, Chang J, Hong C et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. 2020. [Ahead of print, published online 25 February 2020]. doi.org/10.1101/2020.02.22.20026500</mixed-citation><mixed-citation xml:lang="en">Mao L, Wang M, Chen S, He Q, Chang J, Hong C et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. 2020. [Ahead of print, published online 25 February 2020]. doi.org/10.1101/2020.02.22.20026500</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;92:568–576. doi.org/10.1002/jmv.25748</mixed-citation><mixed-citation xml:lang="en">Wang Y, Wang Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;92:568–576. doi.org/10.1002/jmv.25748</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Guo T, Fan Y, Chen M, Wu X, Zhang L, He T et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). J Am Med Assoc Cardiology. 2020;e201017. doi:10.1001/jamacardio.2020.1017</mixed-citation><mixed-citation xml:lang="en">Guo T, Fan Y, Chen M, Wu X, Zhang L, He T et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). J Am Med Assoc Cardiology. 2020;e201017. doi:10.1001/jamacardio.2020.1017</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. [Electronic resource]. URL: https://www.semanticscholar.org/paper/Acute-CerebrovascularDisease-Following-COVID-19%3A-A-Li-Wang/e75aef41f614870f692ccd087bc216d8bf8e8d71#paper-header. doi:10.2139/ssrn.3550025</mixed-citation><mixed-citation xml:lang="en">Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. [Electronic resource]. URL: https://www.semanticscholar.org/paper/Acute-CerebrovascularDisease-Following-COVID-19%3A-A-Li-Wang/e75aef41f614870f692ccd087bc216d8bf8e8d71#paper-header. doi:10.2139/ssrn.3550025</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hackenberg KA, Rajabzadeh-Oghaz H, Dreier R, Buchholz BA, Navid A, Rocke DM et al. Collagen turnover in relation to risk factors and hemodynamics in human intracranial aneurysms. Stroke. 2020;51(5):1624–1628. doi.org/10.1161/STROKEAHA.120.029335</mixed-citation><mixed-citation xml:lang="en">Hackenberg KA, Rajabzadeh-Oghaz H, Dreier R, Buchholz BA, Navid A, Rocke DM et al. Collagen turnover in relation to risk factors and hemodynamics in human intracranial aneurysms. Stroke. 2020;51(5):1624–1628. doi.org/10.1161/STROKEAHA.120.029335</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Muhammad S, Petridis A, Cornelius J-F, Hänggi D. Letter to editor: severe brain haemorrhage and concomitant COVID-19 Infection: A neurovascular complication of COVID-19. Brain Behav Immun. 2020. [Ahead of print, published online 5 May 2020]. doi.org/10.1016/j.bbi.2020.05.015</mixed-citation><mixed-citation xml:lang="en">Muhammad S, Petridis A, Cornelius J-F, Hänggi D. Letter to editor: severe brain haemorrhage and concomitant COVID-19 Infection: A neurovascular complication of COVID-19. Brain Behav Immun. 2020. [Ahead of print, published online 5 May 2020]. doi.org/10.1016/j.bbi.2020.05.015</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Temporary emergency guidance to US stroke centers during the COVID-19 pandemic on behalf of the AHA/ASA stroke council leadership. Stroke. 2020;51(6):1910–1912. doi.org/10.1161/STROKEAHA.120.030023</mixed-citation><mixed-citation xml:lang="en">Temporary emergency guidance to US stroke centers during the COVID-19 pandemic on behalf of the AHA/ASA stroke council leadership. Stroke. 2020;51(6):1910–1912. doi.org/10.1161/STROKEAHA.120.030023</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao J, Rudd A, Liu R. Challenges and potential solutions of stroke care during the coronavirus disease 2019 (COVID-19) outbreak. Stroke. 2020;51(5):1356–1357. doi.org/10.1161/STROKEAHA.120.029701</mixed-citation><mixed-citation xml:lang="en">Zhao J, Rudd A, Liu R. Challenges and potential solutions of stroke care during the coronavirus disease 2019 (COVID-19) outbreak. Stroke. 2020;51(5):1356–1357. doi.org/10.1161/STROKEAHA.120.029701</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Public Health Ontario. Updated IPAC recommendations for use of personal protective equipment for care of individuals with suspect or confirmed COVID-19. 2020. [Electronic resource]. URL: https://www.publichealthontario.ca/-/media/documents/ncov/updated-ipac-measures-covid-19.pdf</mixed-citation><mixed-citation xml:lang="en">Public Health Ontario. Updated IPAC recommendations for use of personal protective equipment for care of individuals with suspect or confirmed COVID-19. 2020. [Electronic resource]. URL: https://www.publichealthontario.ca/-/media/documents/ncov/updated-ipac-measures-covid-19.pdf</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy S, Gomersall CD, Fowler RA. Care for critically ill patients with COVID-19. J Am Med Assoc. 2020. [Ahead of print, published online 11 March 2020]. doi: 10.1001/jama.2020.3633</mixed-citation><mixed-citation xml:lang="en">Murthy S, Gomersall CD, Fowler RA. Care for critically ill patients with COVID-19. J Am Med Assoc. 2020. [Ahead of print, published online 11 March 2020]. doi: 10.1001/jama.2020.3633</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-ncov) patients. Can J Anaesth. 2020;67(5):568–576. doi:10.1007/s12630-020-01591-x</mixed-citation><mixed-citation xml:lang="en">Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-ncov) patients. Can J Anaesth. 2020;67(5):568–576. doi:10.1007/s12630-020-01591-x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tang N, Li D, Wang X. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847. doi:10.1111/jth.14768</mixed-citation><mixed-citation xml:lang="en">Tang N, Li D, Wang X. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847. doi:10.1111/jth.14768</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Beyrouti R, Adams Me, Benjamin L, Cohen H, Farmer SF, Goh YY et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020. [Аhead of print, published online April 30 2020]. doi:10.1136/jnnp-2020–323586</mixed-citation><mixed-citation xml:lang="en">Beyrouti R, Adams Me, Benjamin L, Cohen H, Farmer SF, Goh YY et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020. [Аhead of print, published online April 30 2020]. doi:10.1136/jnnp-2020–323586</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Khosravani H, Rajendram P, Notario L, Chapman MG, Menon BK. Protected code stroke during the COVID-19. Pandemic Stroke. 2020. [Аhead of print, published online 1 April 2020]. doi:10.1161/STROKEAHA.120.029838</mixed-citation><mixed-citation xml:lang="en">Khosravani H, Rajendram P, Notario L, Chapman MG, Menon BK. Protected code stroke during the COVID-19. Pandemic Stroke. 2020. [Аhead of print, published online 1 April 2020]. doi:10.1161/STROKEAHA.120.029838</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ran Li, Chen X, Wang Y, Wu W, Zhang L, Tan X. Risk factors of healthcare workers with corona virus disease 2019: a retrospective cohort study in a designated hospital of Wuhan in China. Clin Infect Dis. 2020;ciaa287. doi:10.1093/cid/ciaa287</mixed-citation><mixed-citation xml:lang="en">Ran Li, Chen X, Wang Y, Wu W, Zhang L, Tan X. Risk factors of healthcare workers with corona virus disease 2019: a retrospective cohort study in a designated hospital of Wuhan in China. Clin Infect Dis. 2020;ciaa287. doi:10.1093/cid/ciaa287</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
