arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2020-26-3-295-303arthyper-1958Research ArticleОБЗОРREVIEWВитамин D как фактор повышения иммунитета и снижения риска развития острых респираторных вирусных инфекций и COVID-19Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID-19https://orcid.org/0000-0002-1547-0123КароноваТ. Л.KaronovaT. L.

Каронова Татьяна Леонидовна — доктор медицинских наук, главный научный сотрудник, руководитель НИЛ клинической эндокринологии, профессор кафедры внутренних болезней

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Tatiana L. Karonova, MD, PhD, DSc, Head, Clinical Endocrinology Laboratory, Professor, Department of Internal Diseases

2 Akkuratov street, St Petersburg, 197341

karonova@mail.ruВашуковаМ. А.VashukovaM. A.

Вашукова Мария Александровна — кандидат медицинских наук, заместитель главного врача по развитию медицинской помощи

Санкт-Петербург

Maria A. Vashukova, MD, PhD, Assistant Chief for Health Care Development

St Petersburg

mavashukova@yahoo.comhttps://orcid.org/0000-0001-9202-3231ГусевД. А.GusevD. A.

Гусев Денис Александрович — доктор медицинских наук, профессор, заведующий кафедрой инфекционных болезней и микробиологии ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России, главный врач СПб ГБУЗ «Клиническая инфекционная больница им. С. П. Боткина»

Санкт-Петербург

Denis A. Gusev, MD, PhD, DSc, Professor, Head, Department for Infectious Deaseses and Microbiology, Almazov National Medical Research Center, Chief, Botkin's Hospital

St Petersburg

gusev_da@almazovcentre.ruГоловатюкК. А.GolovatukK. A.

Головатюк Ксения Андреевна — клинический ординатор по специальности эндокринология

Санкт-Петербург

Ksenia A. Golovatyuk, MD, Post-graduate Student

St Petersburg

ksy2411@mail.ruhttps://orcid.org/0000-0003-0042-7680ГриневаЕ. Н.GrinevaE. N.

Гринева Елена Николаевна — доктор медицинских наук, профессор, директор Института эндокринологии

Санкт-Петербург

Elena N. Grineva, MD, PhD, DSc, Professor, Director, Endocrinology Institute

St Petersburg

grineva_e@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationСанкт-Петербургское государственное бюджетное учреждение здравоохранения «Клиническая инфекционная больница имени С. П. Боткина»РоссияBotkin’s HospitalRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Санкт-Петербургское государственное бюджетное учреждение здравоохранения «Клиническая инфекционная больница имени С. П. Боткина»РоссияAlmazov National Medical Research Centre; Botkin’s HospitalRussian Federation202004062020263295303Copyright © Каронова Т.Л., Вашукова М.А., Гусев Д.А., Головатюк К.А., Гринева Е.Н., 20202020Каронова Т.Л., Вашукова М.А., Гусев Д.А., Головатюк К.А., Гринева Е.Н.Karonova T.L., Vashukova M.A., Gusev D.A., Golovatuk K.A., Grineva E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/1958

В период пандемии COVID-19 усилия исследователей во всем мире направлены на поиск профилактических и лечебных средств для борьбы с SARS-CoV-2. В последние несколько лет установлено, что дефицит витамина D может рассматриваться как один из возможных факторов риска развития и течения респираторной вирусной инфекции. Использование препаратов витамина D может быть оправдано с целью профилактики и лечения при комплексном подходе к терапии таких больных. В представленном обзоре обобщен материал по иммуномодулирующим свойствам витамина D, его роли в профилактике вирусных инфекций, включая новую коронавирусную инфекцию, а также механизмам снижения риска инфекции при помощи терапии витамином D. Надеемся, что данный обзор будет интересен не только эндокринологам, но и врачам смежных специальностей.

During the COVID-19 pandemic, the efforts of many researchers around the world are aimed at finding preventive and prophylactic measures as well as therapeutic agents against SARS-CoV-2. Recent studies have showed that vitamin D deficiency could be one of many factors associated with the development and severity of acute respiratory infections, and vitamin D could be used for prevention and treatment of these patients. This review summarizes data about the role of vitamin D in the pathogenesis and prevention of respiratory viral infections, including new coronavirus infection as well as mechanisms for reducing the risk of infection with vitamin D therapy. Probably, this review will be of interest for endocrinologists and other specialists.

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The authors declare that there are no conflicts of interest present.