arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2020-26-5-490-500arthyper-2036Research ArticleРЕДАКЦИОННАЯ СТАТЬЯEDITORIALСовременные представления о генетике артериальной гипертензии – мозаичная теория, гены-кандидаты, моногенные формы и широкогеномные исследованияCurrent knowledge in hypertension genetics: mosaic theory, candidate genes and genome-wide association studieshttps://orcid.org/0000-0001-8169-7812КонрадиА. О.KonradiA. O.

Конради Александра Олеговна — доктор медицинских наук, профессор, руководитель НИО АГ, заместитель генерального директора по научной работе ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России, руководитель Института трансляционной медицины Университета ИТМО

ул. Аккуратова, д. 2, Санкт-Петербург, 197341Тел.: 8(812)702–37–33 

Aleksandra O. Konradi, MD, PhD, DSc, Professor, Head, Research Department for Arterial Hypertension, Deputy General Director on Research, Almazov National Medical Research Centre; Head; Institute of Translational Medicine, ITMO University

2 Akkuratov street, St Petersburg, 197341Phone: 8(812)702–37–33 

konradi_ao@almazovcentre.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Университет ИТМОРоссияAlmazov National Medical Research Centre; ITMO UniversityRussian Federation202014122020265490500Copyright © Конради А.О., 20202020Конради А.О.Konradi A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2036

В обзоре представлены литературные данные об известных моногенных заболеваниях, сопровождающихся повышением артериального давления (АД), данные о наследовании артериальной гипертензии (АГ) и генах-кандидатах, а также обзор результатов широкогеномных исследований в области АГ. Современное представление о роли генетики в становлении и прогрессировании АГ существенно зависит от совершенствования методов изучения генетических ассоциаций. Высокая производительность новых методов позволила накопить знания о маркерах, ассоциированных с АГ. В настоящее время основная задача исследователей — определить сложные молекулярно-биологические пути регуляции уровня АД, что позволит от популяционного уровня ассоциаций перейти к индивидуальному уровню понимания патогенеза и подходов к лечению.

The article reviews monogenic forms of hypertension, data on the role of heredity of essential hypertension and candidate genes, as well as genome-wide association studies. Modern approach for the role of genetics is driven by implementation of new technologies and their productivity. High performance speed of new technologies like genome-wide association studies provide data for better knowledge of genetic markers of hypertension. The major goal nowadays for research is to reveal molecular pathways of blood pressure regulation, which can help to move from populational to individual level of understanding of pathogenesis and treatment targets.

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The authors declare that there are no conflicts of interest present.