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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2020-26-5-518-525</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-2039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Роль ген-генных и генно-средовых взаимодействий полиморфных локусов ММР в формировании артериальной гипертензии у женщин</article-title><trans-title-group xml:lang="en"><trans-title>The role of gene-gene and gene-environment interactions of polymorphic locuses of MMPs in the formation of hypertension in women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0769-4095</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Москаленко</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Moskalenko</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москаленко Мария Ивановна — кандидат биологических наук, старший преподаватель кафедры медико-биологических дисциплин Медицинского института</p><p>ул. Победы, д. 85, Белгород, 308015Тел.: 8(4722) 30–13–83 </p></bio><bio xml:lang="en"><p>Mariya I. Moskalenko, PhD in Biology, Senior Lecturer, Department of Medical and Biological Disciplines</p><p>85 Pobedy street, Belgorod, 308015Phone: 8(4722)30–13–83 </p></bio><email xlink:type="simple">mariam31011989@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5652-0166</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пономаренко Ирина Васильевна — кандидат медицинских наук, доцент кафедры медико-биологических дисциплин Медицинского института</p><p>Белгород</p></bio><bio xml:lang="en"><p>Irina V. Ponomarenko, MD, PhD, Associate Professor, Department of Medical and Biological Disciplines</p><p>Belgorod</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Верзилина</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Verzilina</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Верзилина Ирина Николаевна — доктор медицинских наук, доцент кафедры медико-биологических дисциплин Медицинского института</p><p>Белгород</p></bio><bio xml:lang="en"><p>Irina N. Verzilina, MD, PhD, DSc, Associate Professor, Department of Medical and Biological Disciplines</p><p>Belgorod</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6395-1626</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремова Ольга Алексеевна — доктор медицинских наук, заведующая кафедрой внутренних болезней № 2 Медицинского института</p><p>Белгород</p></bio><bio xml:lang="en"><p>Olga A. Efremova, MD, PhD, DSc, Head, Department of Internal Diseases #2</p><p>Belgorod</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6280-247X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полоников</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polonikov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полоников Алексей Валерьевич — доктор медицинских наук, профессор, профессор кафедры биологии, медицинской генетики и экологии; директор Научно-исследовательского института генетической и молекулярной эпидемиологии</p><p>Курск</p></bio><bio xml:lang="en"><p>Aleksey V. Polonikov, MD, PhD, DSc, Professor, Department of Biology and Medical Genetics and Ecology; Director, Research Institute of Genetic and Molecular Epidemiology</p><p>Kursk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Belgorod State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Курский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>12</month><year>2020</year></pub-date><volume>26</volume><issue>5</issue><fpage>518</fpage><lpage>525</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Москаленко М.И., Пономаренко И.В., Верзилина И.Н., Ефремова О.А., Полоников А.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Москаленко М.И., Пономаренко И.В., Верзилина И.Н., Ефремова О.А., Полоников А.В.</copyright-holder><copyright-holder xml:lang="en">Moskalenko M.I., Ponomarenko I.V., Verzilina I.N., Efremova O.A., Polonikov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/2039">https://htn.almazovcentre.ru/jour/article/view/2039</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>матриксные металлопротеиназы</kwd><kwd>однонуклеотидный полиморфизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>matrix metalloproteinases</kwd><kwd>single nucleotide polymorphism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M et al. 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