arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2015-21-2-121-129arthyper-204Research ArticleОБЗОРREVIEWРассеянный склероз и уровень обеспеченности витамином DMultiple sclerosis and vitamin D statusКароноваТ. Л.KaronovaT. L.

доктор медицинских наук, заведующая научно-исследовательской лабораторией клинической эндокринологии Института эндокринологии ФГБУ «СЗФМИЦ» Минздрава России, доцент кафедры терапии факультетской с курсом эндокринологии, кардиологии и функциональной диагностики с кли- никой имени Г. Ф. Ланга ГБОУ ВПО ПСПбГМУ им. И. П. Павлова Минздрава России; 

MD, PhD, DMSc, Head, Scientific Research Laboratory of Clinical Endocrinology of Endocrinology Institute, Federal North-West Medical Research Centre; Assistant Professor, Department of Internal Diseases No 2 with the Course of Endocrinology, Cardiology and Functional Diagnostics with Clinic No 1, Pavlov First State Medical University of St. Petersburg; 

ШмонинаИ. А.ShmoninaI. A.

аспирант кафедры терапии факультетской с курсом эндокринологии, кардиологии и функциональ- ной диагностики с клиникой им. Г. Ф. Ланга ГБОУ ВПО ПСПбГМУ им. И. П. Павлова Минздрава России; 

MD, PhD student, Department of Internal Diseases No 2 with the Course of Endocrinology, Cardiology and Functional Diagnostics with Clinic No 1, Pavlov First State Medical University of St. Petersburg; 

liramed@gmail.comТотолянН. А.TotolyanN. A.

доктор медицинских наук, про- фессор кафедры неврологии и нейрохирургии с клиникой ГБОУ ВПО ПСПбГМУ им. И. П. Павлова Минздрава России. 

MD, PhD, DMSc, Professor, Department of Neurology and Neurosurgery with Clinic, Pavlov First State Medical University of St. Petersburg. 

Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр» Министерства здравоохранения Российской Федерации, Санкт-Петербург, Россия Государственное бюджетное образовательное учреждение высшего профессионального образования «Первый Санкт- Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации, Санкт-Петербург, РоссияРоссияFederal North-West Medical Research Centre, St Petersburg, Russia Pavlov First State Medical University of St. Petersburg, St Petersburg, RussiaRussian FederationГосударственное бюджетное образовательное учреждение высшего профессионального образования «Первый Санкт- Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации, Санкт-Петербург, РоссияРоссияPavlov First State Medical University of St. Petersburg, St Petersburg, RussiaRussian Federation201516072015212121129Copyright © Каронова Т.Л., Шмонина И.А., Тотолян Н.А., 20152015Каронова Т.Л., Шмонина И.А., Тотолян Н.А.Karonova T.L., Shmonina I.A., Totolyan N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/204

Хорошо известно, что рассеянный склероз (РС) является хроническим иммуноопосредованным заболеванием центральной нервной системы, характеризующимся поражением преимущественно белого вещества головного и спинного мозга, проявляющимся хроническим прогрессирующим течением и приводящим к необратимой инвалидизации людей молодого возраста, что определяет его высокую социальную и экономическую значимость. Результаты проведенных исследований свидетельствуют о мультифакторной природе этого заболевания. Полагают, что одним из факторов риска развития РС может быть низкий уровень обеспеченности витамином D. Исследование «неклассических» эффектов витамина D, в том числе его влияния на иммунную систему, получило широкое развитие в последние годы. Обзор посвящен анализу клинических и экспериментальных данных об ассоциации дефицита витамина D и рассеянного склероза, обсуждению патогенетических аспектов влияния витамина D на течение этого заболевания, а также анализу необходимости и способов коррекции дефицита витамина D при РС. В публикации представлены данные о перспективах проведения дальнейших исследований в этой области с целью установления оптимальных доз, режима и продолжительности лечения препаратами витамина D при РС. 

Multiple sclerosis (MS) is known to be a chronic immune-mediated disease of the central nervous system characterized by lesions predominantly in white matter of the brain and spinal cord and by a chronic progression. It affects mainly young people and leads to their irreversible disability. This fact determines high social and economic significance of MS. A multifactorial nature of MS is suggested by the results of investigation, and vitamin D deficiency is presumed to be a possible risk factor. “Non-classical” effects of vitamin D, including its effect on the immune response, are widely studied in the recent years. This review is devoted to the analysis of clinical and experimental data about the association between vitamin D deficiency and MS. It also discusses the pathogenetic effect of vitamin D and analyzed the need and ways for correction of vitamin D deficiency in MS. In this publication we discuss the possible direction of further research in order to establish the optimal dosage and duration of vitamin D treatment in MS. 

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The authors declare that there are no conflicts of interest present.