<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2020-26-5-573-580</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-2044</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Роль АТФ и транспортеров ионов Cl–  в регуляции сократительной активности гладких мышц легочной артерии в гипоосмотической среде</article-title><trans-title-group xml:lang="en"><trans-title>Role of ATP and Cl– transporters in regulation of contractile activity of pulmonary artery smooth muscles in hyposmotic conditions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смаглий</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smaglii</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смаглий Людмила Вячеславовна — кандидат медицинских наук, доцент кафедры биофизики и функциональной диагностики</p><p>ул. Московский тракт, д. 2, Томск, 634050</p></bio><bio xml:lang="en"><p>Lyudmila V. Smaglii, MD, PhD, Associate Professor, Biophysics and Functional Diagnostics Department</p><p>2 Moskovskii trakt, Tomsk, 634050</p></bio><email xlink:type="simple">lud.smagly@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусакова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusakova</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусакова Виктория Сергеевна — ассистент кафедры биофизики и функциональной диагностики</p><p>Томск</p></bio><bio xml:lang="en"><p>Viktoriya S. Gusakova, MD, Assistant Professor, Biophysics and Functional Diagnostics Department</p><p>Tomsk</p></bio><email xlink:type="simple">ryd4enkoviktoriya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горянова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorianova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горянова Анна Михайловна — аспирант кафедры биофизики и функциональной диагностики</p><p>Томск</p></bio><bio xml:lang="en"><p>Anna M. Gorianova, Postgraduate Student, Biophysics and Functional Diagnostics Department</p><p>Tomsk</p></bio><email xlink:type="simple">asulita@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голованов</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovanov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голованов Егор Александрович — аспирант кафедры биофизики и функциональной диагностики</p><p>Томск</p></bio><bio xml:lang="en"><p>Egor A. Golovanov, Postgraduate Student, Biophysics and Functional Diagnostics Department</p><p>Tomsk</p></bio><email xlink:type="simple">golovanovbf@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чибисов</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chibisov</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чибисов Егор Евгеньевич — ординатор</p><p>Томск</p></bio><bio xml:lang="en"><p>Еgor Е. Chibisov, Resident</p><p>Tomsk</p></bio><email xlink:type="simple">einmatik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бирулина</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Birulina</surname><given-names>J. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бирулина Юлия Георгиевна — кандидат медицинских наук, доцент кафедры биофизики и функциональной диагностики</p><p>Томск</p></bio><bio xml:lang="en"><p>Juliya G. Birulina, MD, PhD, Associate Professor, Biophysics and Functional Diagnostics Department</p><p>Tomsk</p></bio><email xlink:type="simple">birulina20@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусакова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusakova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусакова Светлана Валерьевна — доктор медицинских наук, заведующая кафедрой биофизики и функциональной диагностики</p><p>Томск</p></bio><bio xml:lang="en"><p>Svetlana V. Gusakova, MD, PhD, DSc, Head, Biophysics and Functional Diagnostics Department</p><p>Tomsk</p></bio><email xlink:type="simple">gusakova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>12</month><year>2020</year></pub-date><volume>26</volume><issue>5</issue><fpage>573</fpage><lpage>580</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смаглий Л.В., Гусакова В.С., Горянова А.М., Голованов Е.А., Чибисов Е.Е., Бирулина Ю.Г., Гусакова С.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Смаглий Л.В., Гусакова В.С., Горянова А.М., Голованов Е.А., Чибисов Е.Е., Бирулина Ю.Г., Гусакова С.В.</copyright-holder><copyright-holder xml:lang="en">Smaglii L.V., Gusakova V.S., Gorianova A.M., Golovanov E.A., Chibisov E.E., Birulina J.G., Gusakova S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/2044">https://htn.almazovcentre.ru/jour/article/view/2044</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>легочная артерия</kwd><kwd>гладкомышечные клетки</kwd><kwd>Na+</kwd><kwd>K+</kwd><kwd>2Cl–-котранспорт</kwd><kwd>Cl–-каналы</kwd><kwd>АТФ</kwd><kwd>гипоосмотическое сокращение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pulmonary artery</kwd><kwd>smooth muscle cells</kwd><kwd>Na+</kwd><kwd>K+</kwd><kwd>2Cl– cotransport</kwd><kwd>Cl–-channels</kwd><kwd>ATP</kwd><kwd>hypoosmotic contraction</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке РФФИ (18–44–703008, 18–44–700009, 18–315–00296) и администрации Томской области (договор № 19–27).</funding-statement><funding-statement xml:lang="en">The research work is supported by the grant of the Russian Foundation of Fundamental Studies (18–44–703008, 18–44–700009, 18–315–00296) and the administrations of Tomsk region (agreement № 19–27).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pak O, Aldashev A, Welsh D, Peacock A. The effects of hypoxia on the cells of the pulmonary vasculature. Eur Respir J. 2007;30(2):364–372. doi:10.1183/09031936.00128706</mixed-citation><mixed-citation xml:lang="en">Pak O, Aldashev A, Welsh D, Peacock A. The effects of hypoxia on the cells of the pulmonary vasculature. Eur Respir J. 2007;30(2):364–372. doi:10.1183/09031936.00128706</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K et al. The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol. 2012;97(6):796–806. doi:10.1113/expphysiol.2012.065474</mixed-citation><mixed-citation xml:lang="en">Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K et al. The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol. 2012;97(6):796–806. doi:10.1113/expphysiol.2012.065474</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sweeney M, Jason XJY. Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels. Respir Res. 2000;1(1):40–48. doi:10.1186/rr11</mixed-citation><mixed-citation xml:lang="en">Sweeney M, Jason XJY. Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels. Respir Res. 2000;1(1):40–48. doi:10.1186/rr11</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sun H, Xia Y, Paudel O, Yang XR, Sham JS. Chronic hypoxia-induced upregulation of Ca2+-activated Cl-channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol. 2012;590(15):3507–3521. doi:10.1113/jphysiol.2012.232520</mixed-citation><mixed-citation xml:lang="en">Sun H, Xia Y, Paudel O, Yang XR, Sham JS. Chronic hypoxia-induced upregulation of Ca2+-activated Cl-channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol. 2012;590(15):3507–3521. doi:10.1113/jphysiol.2012.232520</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wang K, Chen C, Ma J, Lao J, Pang Y. Contribution of calcium-activated chloride channel to elevated pulmonary artery pressure in pulmonary arterial hypertension induced by high pulmonary blood flow. Int J Clin Exp Pathol. 2015;8(1):146–154.</mixed-citation><mixed-citation xml:lang="en">Wang K, Chen C, Ma J, Lao J, Pang Y. Contribution of calcium-activated chloride channel to elevated pulmonary artery pressure in pulmonary arterial hypertension induced by high pulmonary blood flow. Int J Clin Exp Pathol. 2015;8(1):146–154.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Forrest AS, Joyce TC, Huebner ML, Ayon RJ, Wiwchar M, Joyce J et al. Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012;303(12):C 1229–C 1243. doi:10.1152/ajpcell.00044.2012</mixed-citation><mixed-citation xml:lang="en">Forrest AS, Joyce TC, Huebner ML, Ayon RJ, Wiwchar M, Joyce J et al. Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012;303(12):C 1229–C 1243. doi:10.1152/ajpcell.00044.2012</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wang K, Ma J, Pang Y, Lao J, Pan X, Tang Q et al. Niflumic acid attenuated pulmonary artery tone and vascular structural remodeling of pulmonary arterial hypertension induced by high pulmonary blood flow in vivo. J Cardiovasc Pharmacol. 2015;66(4):383–391. doi:10.1097/FJC.0000000000000291</mixed-citation><mixed-citation xml:lang="en">Wang K, Ma J, Pang Y, Lao J, Pan X, Tang Q et al. Niflumic acid attenuated pulmonary artery tone and vascular structural remodeling of pulmonary arterial hypertension induced by high pulmonary blood flow in vivo. J Cardiovasc Pharmacol. 2015;66(4):383–391. doi:10.1097/FJC.0000000000000291</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Orlov SN, Koltsova SV, Kapilevich LV, Gusakova SV, Dulin NO. NKCC 1 and NKCC 2: the pathogenetic role of cationchloride cotransporters in hypertension. Genes Dis. 2015;2(2):186–196. doi:10.1016/j.gendis.2015.02.007</mixed-citation><mixed-citation xml:lang="en">Orlov SN, Koltsova SV, Kapilevich LV, Gusakova SV, Dulin NO. NKCC 1 and NKCC 2: the pathogenetic role of cationchloride cotransporters in hypertension. Genes Dis. 2015;2(2):186–196. doi:10.1016/j.gendis.2015.02.007</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Burnstock G, Ralevic V. Purinergic signaling and blood vessels in health and disease. Pharmacol Rev. 2014;66(1):102–192. doi:10.1124/pr.113.008029</mixed-citation><mixed-citation xml:lang="en">Burnstock G, Ralevic V. Purinergic signaling and blood vessels in health and disease. Pharmacol Rev. 2014;66(1):102–192. doi:10.1124/pr.113.008029</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dietrich HH, Ellsworth ML, Sprague RS, Dacey RG. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol Heart Circ Physiol. 2000;278(4): H1294–H1298. doi:10.1152/ajpheart.2000.278.4.H1294</mixed-citation><mixed-citation xml:lang="en">Dietrich HH, Ellsworth ML, Sprague RS, Dacey RG. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol Heart Circ Physiol. 2000;278(4): H1294–H1298. doi:10.1152/ajpheart.2000.278.4.H1294</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, Sprague RS. Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology. 2008;24:107–116. doi:10.1152/physiol.00038.2008</mixed-citation><mixed-citation xml:lang="en">Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, Sprague RS. Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology. 2008;24:107–116. doi:10.1152/physiol.00038.2008</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Locovei S, Wang J, Dahl G. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett. 2006;580(1):239–244. doi:10.1016/j.febslet.2005.12.004</mixed-citation><mixed-citation xml:lang="en">Locovei S, Wang J, Dahl G. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett. 2006;580(1):239–244. doi:10.1016/j.febslet.2005.12.004</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sprague RS, Ellsworth ML. Erythrocyte derived ATP and perfusion distribution: role of intracellular and intracellular communication. Microcirculation. 2012;19(5):430–439. doi:10.1111/j.1549-8719.2011.00158.x</mixed-citation><mixed-citation xml:lang="en">Sprague RS, Ellsworth ML. Erythrocyte derived ATP and perfusion distribution: role of intracellular and intracellular communication. Microcirculation. 2012;19(5):430–439. doi:10.1111/j.1549-8719.2011.00158.x</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sprague RS, Ellsworth ML, Stephenson AH, Lonigro AJ. Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release. Am J Physiol Cell Physiol. 2001;281(4): C1158–C1164. doi:10.1152/ajpcell.2001.281.4.C1158</mixed-citation><mixed-citation xml:lang="en">Sprague RS, Ellsworth ML, Stephenson AH, Lonigro AJ. Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release. Am J Physiol Cell Physiol. 2001;281(4): C1158–C1164. doi:10.1152/ajpcell.2001.281.4.C1158</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Inglis SK, Olver RE, Wilson SM. Differential effects of UTP and ATP on ion transport in porcine tracheal epithelium. Br J Pharmacol. 2000;130(2):367–374. doi:10.1038/sj.bjp.0703324</mixed-citation><mixed-citation xml:lang="en">Inglis SK, Olver RE, Wilson SM. Differential effects of UTP and ATP on ion transport in porcine tracheal epithelium. Br J Pharmacol. 2000;130(2):367–374. doi:10.1038/sj.bjp.0703324</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Paradiso AM, Ribeiro CM, Boucher RC. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia. J Gen Physiol. 2001;117(1):53–67. doi:10.1085/jgp.117.1.53</mixed-citation><mixed-citation xml:lang="en">Paradiso AM, Ribeiro CM, Boucher RC. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia. J Gen Physiol. 2001;117(1):53–67. doi:10.1085/jgp.117.1.53</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kunzelmann K, Schreiber R, Cook D. Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. Pflugers Arch. 2002;444(1–2):220–226. doi:10.1007/s00424-002-0796-y</mixed-citation><mixed-citation xml:lang="en">Kunzelmann K, Schreiber R, Cook D. Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. Pflugers Arch. 2002;444(1–2):220–226. doi:10.1007/s00424-002-0796-y</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wong CH, Ko WH. Stimulation of Cl — secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia. J Biol Chem. 2002;277(11):9016–9021. doi:10.1074/jbc.M111917200</mixed-citation><mixed-citation xml:lang="en">Wong CH, Ko WH. Stimulation of Cl — secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia. J Biol Chem. 2002;277(11):9016–9021. doi:10.1074/jbc.M111917200</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mongin AA, Kimelberg HK. ATP regulates anion channelmediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms. Am J Physiol Cell Physiol. 2005;288(1):C 204–C 213. doi:10.1152/ajpcell.00330.2004</mixed-citation><mixed-citation xml:lang="en">Mongin AA, Kimelberg HK. ATP regulates anion channelmediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms. Am J Physiol Cell Physiol. 2005;288(1):C 204–C 213. doi:10.1152/ajpcell.00330.2004</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Roman R, Lidofsky SD, Fitz JG. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Natl Acad Sci USA. 1996;93(21):1202012025. doi:10.1073/pnas.93.21.12020</mixed-citation><mixed-citation xml:lang="en">Wang Y, Roman R, Lidofsky SD, Fitz JG. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Natl Acad Sci USA. 1996;93(21):1202012025. doi:10.1073/pnas.93.21.12020</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Akimova OA, Grygorzcyk A, Bundey RA, Bourcier N, Gekle M, Insel PA et al. Transient activation and delayed inhibition of Na+, K+, Cl– cotransport in ATP-treated C 11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem. 2006;281(42):31317–31325. doi:10.1074/jbc.m602117200</mixed-citation><mixed-citation xml:lang="en">Akimova OA, Grygorzcyk A, Bundey RA, Bourcier N, Gekle M, Insel PA et al. Transient activation and delayed inhibition of Na+, K+, Cl– cotransport in ATP-treated C 11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem. 2006;281(42):31317–31325. doi:10.1074/jbc.m602117200</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev. 2007;87(2):659–797. doi:10.1152/physrev.00043.2006</mixed-citation><mixed-citation xml:lang="en">Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev. 2007;87(2):659–797. doi:10.1152/physrev.00043.2006</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher SK, Cheema TA, Foster DJ, Heacock AM. Volumedependent osmolyte efflux from neuronal tissues: regulation by G-protein-coupled receptors. J Neurochem. 2008;106(5):19982014. doi:10.1111/j.1471-4159.2008.05510.x</mixed-citation><mixed-citation xml:lang="en">Fisher SK, Cheema TA, Foster DJ, Heacock AM. Volumedependent osmolyte efflux from neuronal tissues: regulation by G-protein-coupled receptors. J Neurochem. 2008;106(5):19982014. doi:10.1111/j.1471-4159.2008.05510.x</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Franco R, Panayiotidis MI, de La Paz LD. Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors. J Cell Physiol. 2008;216(1):14–28. doi:10.1002/jcp.21406</mixed-citation><mixed-citation xml:lang="en">Franco R, Panayiotidis MI, de La Paz LD. Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors. J Cell Physiol. 2008;216(1):14–28. doi:10.1002/jcp.21406</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vazquez-Juarez E, Ramos-Mandujano G, HernandezBenitez R, Pasantes-Morales H. On the role of G-protein-coupled receptors in cell volume regulation. Cell Physiol Biochem. 2008;21(1–3):1–14. doi:10.1159/000113742</mixed-citation><mixed-citation xml:lang="en">Vazquez-Juarez E, Ramos-Mandujano G, HernandezBenitez R, Pasantes-Morales H. On the role of G-protein-coupled receptors in cell volume regulation. Cell Physiol Biochem. 2008;21(1–3):1–14. doi:10.1159/000113742</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sun XZ, Tian XY, Wang DW, Li J. Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. Eur Rev Med Pharmacol Sci. 2014;18(7):959–964.</mixed-citation><mixed-citation xml:lang="en">Sun XZ, Tian XY, Wang DW, Li J. Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. Eur Rev Med Pharmacol Sci. 2014;18(7):959–964.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Roman RM, Feranchak AP, Salter KD, Wang Y, Fitz JG. Endogenous ATP release regulates Cl- secretion in cultured human and rat biliary epithelial cells. Am J Physiol. 1999;276(6):G1391G1400. doi:10.1152/ajpgi.1999.276.6.G1391</mixed-citation><mixed-citation xml:lang="en">Roman RM, Feranchak AP, Salter KD, Wang Y, Fitz JG. Endogenous ATP release regulates Cl- secretion in cultured human and rat biliary epithelial cells. Am J Physiol. 1999;276(6):G1391G1400. doi:10.1152/ajpgi.1999.276.6.G1391</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Feranchak AP, Fitz JG, Roman RM. Volume-sensitive purinergic signaling in human hepatocytes. J Hepatol. 2000;33(2):174–182. doi:10.1016/s0168-8278(00)80357-8</mixed-citation><mixed-citation xml:lang="en">Feranchak AP, Fitz JG, Roman RM. Volume-sensitive purinergic signaling in human hepatocytes. J Hepatol. 2000;33(2):174–182. doi:10.1016/s0168-8278(00)80357-8</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sabirov RS, Okada Y. ATP release via anion channels. Purinergic Signaling. 2005;1(4):311–328. doi:10.1007/s11302005-1557-0</mixed-citation><mixed-citation xml:lang="en">Sabirov RS, Okada Y. ATP release via anion channels. Purinergic Signaling. 2005;1(4):311–328. doi:10.1007/s11302005-1557-0</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gradilone SA, Masyuk AI, Splinter PL, Banales JM, Huang BQ, Tietz PS et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci USA. 2007;104(48):19138–19143. doi:10.1073/pnas.0705964104</mixed-citation><mixed-citation xml:lang="en">Gradilone SA, Masyuk AI, Splinter PL, Banales JM, Huang BQ, Tietz PS et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci USA. 2007;104(48):19138–19143. doi:10.1073/pnas.0705964104</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev. 2009;89(1):193–277. doi:10.1152/physrev.00037.2007</mixed-citation><mixed-citation xml:lang="en">Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev. 2009;89(1):193–277. doi:10.1152/physrev.00037.2007</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bang L, Boesgaard S, Nielsen-Kudsk JE, Vejlstrup NG, Aldershvile J. Nitroglycerin-mediated vasorelaxation is modulated by endothelial calcium-activated potassium channels. Cardiovasc Res. 1999;43(3):772–778.</mixed-citation><mixed-citation xml:lang="en">Bang L, Boesgaard S, Nielsen-Kudsk JE, Vejlstrup NG, Aldershvile J. Nitroglycerin-mediated vasorelaxation is modulated by endothelial calcium-activated potassium channels. Cardiovasc Res. 1999;43(3):772–778.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gao YJ, Lee RMKW. Hydrogen peroxide is an endotheliumdependent contracting factor in rat renal artery. Br J Pharmacol. 2005;146(8):1061–1068. doi:10.1038/sj.bjp.0706423</mixed-citation><mixed-citation xml:lang="en">Gao YJ, Lee RMKW. Hydrogen peroxide is an endotheliumdependent contracting factor in rat renal artery. Br J Pharmacol. 2005;146(8):1061–1068. doi:10.1038/sj.bjp.0706423</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Li JR, Zhao YS, Chang Y, Yang SC, Guo YJ, Ji ES. Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway. PLoS ONE. 2018;13(4): e019560. doi:10.1371/journal.pone.0195604</mixed-citation><mixed-citation xml:lang="en">Li JR, Zhao YS, Chang Y, Yang SC, Guo YJ, Ji ES. Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway. PLoS ONE. 2018;13(4): e019560. doi:10.1371/journal.pone.0195604</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Anfinogenova YJ, Baskakov MB, Kovalev IV, Kilin AA, Dulin NO, Orlov SN. Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl – cotransport, intracellular Cl – and L-type Ca2+ channels. Pflügers Arch. 2004;449(1):42–55.</mixed-citation><mixed-citation xml:lang="en">Anfinogenova YJ, Baskakov MB, Kovalev IV, Kilin AA, Dulin NO, Orlov SN. Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl – cotransport, intracellular Cl – and L-type Ca2+ channels. Pflügers Arch. 2004;449(1):42–55.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Koltsova SV, Gusakova SV, Anfinogenova YJ, Baskakov MB, Orlov SN. Vascular smooth muscle contraction evoked by cell volume modulation: role of the cytoskeleton network. Cell Physiol Biochem. 2008;21(1–3):29–36.</mixed-citation><mixed-citation xml:lang="en">Koltsova SV, Gusakova SV, Anfinogenova YJ, Baskakov MB, Orlov SN. Vascular smooth muscle contraction evoked by cell volume modulation: role of the cytoskeleton network. Cell Physiol Biochem. 2008;21(1–3):29–36.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Orlov SN, Resink TJ, Bernhardt J, Buhler FR. Volumedependent regulation of sodium and potassium fluxes in cultured vascular smooth muscle cells: dependence on medium osmolality and regulation by signalling systems. J Membrane Biol. 1992;129(2): 199–210.</mixed-citation><mixed-citation xml:lang="en">Orlov SN, Resink TJ, Bernhardt J, Buhler FR. Volumedependent regulation of sodium and potassium fluxes in cultured vascular smooth muscle cells: dependence on medium osmolality and regulation by signalling systems. J Membrane Biol. 1992;129(2): 199–210.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Burnstock G. Purinergic mechanisms. Ann N Y Acad Sci. 1990;603:1–17. doi:10.1111/j.1749-6632.1990.tb37657.x</mixed-citation><mixed-citation xml:lang="en">Burnstock G. Purinergic mechanisms. Ann N Y Acad Sci. 1990;603:1–17. doi:10.1111/j.1749-6632.1990.tb37657.x</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue T, Kannan MS. Nonadrenergic and noncholinergic excitatory neurotransmission in rat intrapulmonary artery. Am J Physiol. 1988;254(6Pt2):H1142–H114. doi:10.1152/ajpheart.1988.254.6.H1142</mixed-citation><mixed-citation xml:lang="en">Inoue T, Kannan MS. Nonadrenergic and noncholinergic excitatory neurotransmission in rat intrapulmonary artery. Am J Physiol. 1988;254(6Pt2):H1142–H114. doi:10.1152/ajpheart.1988.254.6.H1142</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Katsuragi T, Tokunaga T, Ogawa S, Soejima O, Sato C, Furukawa T. Existence of ATP-evoked ATP release system in smooth muscles. J Pharmacol Exp Ther. 1991;259(2):513–518.</mixed-citation><mixed-citation xml:lang="en">Katsuragi T, Tokunaga T, Ogawa S, Soejima O, Sato C, Furukawa T. Existence of ATP-evoked ATP release system in smooth muscles. J Pharmacol Exp Ther. 1991;259(2):513–518.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Pearson JD, Gordon JL. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature. 1979;281(5730):384–386.</mixed-citation><mixed-citation xml:lang="en">Pearson JD, Gordon JL. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature. 1979;281(5730):384–386.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Grygorczyk R, Orlov SN. Effects of hypoxia on erythrocyte membrane properties — implications for intravascular hemolysis and purinergic control of blood flow. Front Physiol. 2017;8:1110.</mixed-citation><mixed-citation xml:lang="en">Grygorczyk R, Orlov SN. Effects of hypoxia on erythrocyte membrane properties — implications for intravascular hemolysis and purinergic control of blood flow. Front Physiol. 2017;8:1110.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Hakim TS, Ferrario L, Freedman JC, Carlin RE, Camporesi EM. Segmental pulmonary vascular responses to ATP in rat lungs: role of nitric oxide. J Appl Physiol. 1997;82(3):852–858.</mixed-citation><mixed-citation xml:lang="en">Hakim TS, Ferrario L, Freedman JC, Carlin RE, Camporesi EM. Segmental pulmonary vascular responses to ATP in rat lungs: role of nitric oxide. J Appl Physiol. 1997;82(3):852–858.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Boarder MR, Weisman GA, Turner JT, Wilkinson GF. G-protein-coupled P2purinoceptors: from molecular biology to functional responses. Trends Pharmacol Sci. 1995;16(4):133–139. doi:10.1016/S0165-6147(00)89001-X</mixed-citation><mixed-citation xml:lang="en">Boarder MR, Weisman GA, Turner JT, Wilkinson GF. G-protein-coupled P2purinoceptors: from molecular biology to functional responses. Trends Pharmacol Sci. 1995;16(4):133–139. doi:10.1016/S0165-6147(00)89001-X</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Liu SF, McCormack DG, Evans TW, Barnes PJ. Characterization and distribution of P2-purinoceptor subtypes in rat pulmonary vessels. J Pharmacol Exp Ther. 1989;251(3):12041210.</mixed-citation><mixed-citation xml:lang="en">Liu SF, McCormack DG, Evans TW, Barnes PJ. Characterization and distribution of P2-purinoceptor subtypes in rat pulmonary vessels. J Pharmacol Exp Ther. 1989;251(3):12041210.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Liu SF, McCormack DG, Evans TW, Barnes PJ. Evidence for two P2-purinoceptor subtypes in human small pulmonary arteries. Br J Pharmacol. 1989;98(3):1014–1020.</mixed-citation><mixed-citation xml:lang="en">Liu SF, McCormack DG, Evans TW, Barnes PJ. Evidence for two P2-purinoceptor subtypes in human small pulmonary arteries. Br J Pharmacol. 1989;98(3):1014–1020.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Neely CF, Haile DM, Cahill BE, Kadowitz PJ. Adenosine and ATP produce vasoconstriction in the feline pulmonary vascular bed by different mechanisms. J Pharmacol Exp Ther. 1991;258(3):753–761.</mixed-citation><mixed-citation xml:lang="en">Neely CF, Haile DM, Cahill BE, Kadowitz PJ. Adenosine and ATP produce vasoconstriction in the feline pulmonary vascular bed by different mechanisms. J Pharmacol Exp Ther. 1991;258(3):753–761.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Neely CF, Kadowitz PJ, Lippton H, Neiman M, Hyman AL. Adenosine does not mediate the pulmonary vasodilator response of adenosine 5’-triphosphate in the feline pulmonary vascular bed. J Pharmacol Exp Ther. 1989;250:170–176.</mixed-citation><mixed-citation xml:lang="en">Neely CF, Kadowitz PJ, Lippton H, Neiman M, Hyman AL. Adenosine does not mediate the pulmonary vasodilator response of adenosine 5’-triphosphate in the feline pulmonary vascular bed. J Pharmacol Exp Ther. 1989;250:170–176.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Souza R, Amato MBP, Demarzo SE, Deheinzelin D, Barbas CSV, Schettino GPP et al. Pulmonary capillary pressure in pulmonary hypertension. Crit Care. 2005;9(2):R 132–R 138.</mixed-citation><mixed-citation xml:lang="en">Souza R, Amato MBP, Demarzo SE, Deheinzelin D, Barbas CSV, Schettino GPP et al. Pulmonary capillary pressure in pulmonary hypertension. Crit Care. 2005;9(2):R 132–R 138.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Rackow EC, Alan Fein I, Leppo J. Colloid osmotic pressure as a prognostic indicator of pulmonary edema and mortality in the critically ill. Chest. 1977;72:709–713. doi:10.1378/chest.72.6.709</mixed-citation><mixed-citation xml:lang="en">Rackow EC, Alan Fein I, Leppo J. Colloid osmotic pressure as a prognostic indicator of pulmonary edema and mortality in the critically ill. Chest. 1977;72:709–713. doi:10.1378/chest.72.6.709</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Perry PB, O’Neill WC. Swelling-activated K fluxes in vascular endothelial cells: volume regulation via K-Cl cotransport and K channels. Am J Physiol. 1993;265(3Pt1): C 763–C 769. doi:10.1152/ajpcell.1993.265.3.C763</mixed-citation><mixed-citation xml:lang="en">Perry PB, O’Neill WC. Swelling-activated K fluxes in vascular endothelial cells: volume regulation via K-Cl cotransport and K channels. Am J Physiol. 1993;265(3Pt1): C 763–C 769. doi:10.1152/ajpcell.1993.265.3.C763</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
