arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2022-28-1-6-16arthyper-2061Research ArticleОБЗОРREVIEWАртериальная гипертензия у пациентов с псориазом и псориатическим артритомHypertension in patients with psoriasis and psoriatic arthritishttps://orcid.org/0000-0001-5111-2131ШишкинА. Н.ShishkinA. N.

Шишкин Александр Николаевич — доктор медицинских наук, профессор, заведующий кафедрой факультетской терапии медицинского факультета

21-я линия В.О., д. 8а, СанктПетербург, 199106

Alexander N. Shishkin, MD, PhD, DSc, Professor, Head, Department of Faculty Therapy, Medical Faculty

8a 27 line V.O., St Petersburg, 199106

alexshishkin@bk.ruhttps://orcid.org/0000-0002-6625-9010НиколаеваА. А.NikolaevaA. A.

Николаева Алина Александровна—аспирант кафедры факультетской терапии медицинского факультета

21-я линия В.О., д. 8а, СанктПетербург, 199106

Alina A. Nikolaeva, MD, Postgraduate Student, Department of Faculty Therapy, Medical Faculty

8a 27 line V.O., St Petersburg, 199106

alina327k@rambler.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»РоссияSt. Petersburg State UniversityRussian Federation202215092021281616Copyright © Шишкин А.Н., Николаева А.А., 20222022Шишкин А.Н., Николаева А.А.Shishkin A.N., Nikolaeva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2061

В статье приводятся данные об особенностях артериальной гипертензии (АГ) и факторах риска ее развития у пациентов с псориазом (ПсО) и псориатическим артритом (ПсА). Известно, что ПсО и ПсА часто сопровождаются сердечно-сосудистыми заболеваниями. Возникновение кардиоваскулярной патологии в данном случае связано как с хроническим системным Th1-Th17-опосредованным воспалением, так и с метаболическими изменениями, наблюдающимся в этой группе больных значительно чаще, чем в общей популяции. В настоящее время имеются данные, свидетельствующие о повышенной частоте АГ у лиц с ПсО, однако патофизиологическая связь этих нозологий до конца не определена. На развитие АГ при ПсО и ПсА оказывает влияние множество аспектов. Во-первых, при данных заболеваниях отмечаются выраженные нарушения всех видов обмена веществ: белкового (гиперурикемия), углеводного (гипергликемия) и жирового (дислипидемия). Более того, наличие ПсО и ПсА часто вызывает стресс и депрессию и, как следствие, предрасполагает к курению, употреблению алкоголя, гиподинамии, являющимися модифицируемыми факторами кардиоваскулярного риска. Также повышение уровня артериального давления могут вызывать препараты для лечения кожных поражений и воспаления в суставах. Анализируя результаты различных исследований, можно сделать вывод о том, что у пациентов с ПсО и ПсА нет оснований избегать применения определенных антигипертензивных препаратов. Кардиоваскулярная патология оказывает серьезное влияние на качество жизни, социальную адаптацию, терапевтические возможности больных с ПсО и ПсА, что подчеркивает актуальность изучаемой проблемы.

The article presents data on the features of hypertension (HTN) and the risk factors for its development in patients with psoriasis (PsO) and psoriatic arthritis (PsA). PsO and PsA are often accompanied by cardiovascular diseases which are associated with both chronic systemic Th1-Th17-mediated inflammation and metabolic changes in this group of patients. Currently, data show high rates of HTN in PsO, however, the pathophysiological relationship of these pathologies has not been fully determined. HTN development in PsO and PsA is mediated by many factors. Firstly, metabolism disorders including hyperuricemia, hyperglycemia, dyslipidemia can play a role. Moreover, PsO and PsA often cause stress and depression predisposing to smoking, alcohol consumption, hypodynamia, which are modifiable cardiovascular risk factors. Also, the medications for skin lesions and joint inflammation can lead to high blood pressure. In conclusion, there is no reason to avoid the use of certain antihypertensive drugs in PsO and PsA. Cardiovascular pathology significantly affects the quality of life, social adaptation, and the treatment opportunities of PsO and PsA.

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The authors declare that there are no conflicts of interest present.