arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2021-27-4-390-401arthyper-2070Research ArticleОБЗОРREVIEWСердечные тропонины при артериальной гипертензии: механизмы повышения и диагностическая ценностьCardiac troponins in hypertension: mechanisms of increase and diagnostic valuehttps://orcid.org/0000-0002-2712-0227ЧаулинА. М.ChaulinA. M.

Чаулин Алексей Михайлович—аспирант, ассистент кафедры гистологии и эмбриологии, Самарский государственный медицинский университет, врач, Самарский областной клинический кардиологический диспансер, лаборант-исследователь, НИИ кардиологии СамГМУ.

Ул. Чапаевская, д. 89, Самара, 443099

Aleksey Michailovich Chaulin - Post-graduate Student, Assistant Department of Histology and Embryology, Samara SMU; Samara Regional Clinical Cardiology Dispensary, Assistant-researcher, Research Institute of Cardiology of SamSMU.

89 Chapaevskaya str., Samara, 443099

alekseymichailovich22976@gmail.comhttps://orcid.org/0000-0002-6453-2976ДупляковД. В.DuplyakovD. V.

Дупляков Дмитрий Викторович — доктор медицинских наук, профессор кафедры кардиологии и сердечно-сосудистой хирургии, СамГМУ, заместитель главного врача по медицинской части, Самарский областной клинический кардиологический диспансер, директор, НИИ кардиологии СамГМУ.

Ул. Чапаевская, д. 89, Самара, 443099

Dmitriy Viktorovich Duplyakov - MD, PhD, DSc, Professor, Department of Cardiology and Cardiovascular Surgery, Samara SMU, deputy chief medical officer, Samara Regional Clinical Cardiology Dispensary, Director, Research Institute of Cardiology of SamSMU.

89 Chapaevskaya str., Samara, 443099

alekseymichailovich22976@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования Самарский государственный медицинский университет Министерства здравоохранения Российской Федерации; Государственное бюджетное учреждение здравоохранения Самарский областной клинический кардиологический диспансерРоссияSamara State Medical University; Samara Regional Clinical Cardiology DispensaryRussian Federation202119102021274390401Copyright © Чаулин А.М., Дупляков Д.В., 20212021Чаулин А.М., Дупляков Д.В.Chaulin A.M., Duplyakov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2070

Представления о диагностической и прогностической ценности многих биомаркеров сердечно-сосудистых заболеваний (ССЗ), включая сердечные тропонины (cTnT и cTnI), значительно меняются с развитием методов их определения. Новые высокочувствительные иммуноанализы могут детектировать минимальные концентрации белковых молекул сердечных тропонинов в биологических жидкостях (несколько нг/л и менее), позволяя выявлять cTnT и cTnI у всех здоровых индивидуумов. Наряду с этим появляются возможности использования cTnT и cTnI как для оценки риска развития ССЗ у здоровых людей, так и для выявления и мониторинга многих ранних патологических состояний, представляющих опасность для сердечно-сосудистой системы и жизни пациентов. К числу таковых патологических состояний относится артериальная гипертензия (АГ), которая является непосредственной причиной развития ишемической болезни сердца, острого инфаркта миокарда, инсульта и ряда других ССЗ. В ряде недавних исследований сообщается о возможности использования высокочувствительных cTnT и cTnI при ведении пациентов с АГ. В данной статье мы подробно рассматриваем диагностическое и прогностическое значение сердечных тропонинов при АГ, а также обсуждаем основные возможные механизмы, лежащие в основе повышения cTnT и cTnI при АГ в биологических жидкостях человека.

The understanding of the diagnostic and prognostic value of many biomarkers of cardiovascular diseases (CVD), including cardiac troponins (cTnT and cTnI), is changing significantly with the development of methods for their determination. New highly sensitive immunoassays can detect minimal concentrations of cardiac troponin protein molecules in biological fluids (several ng/L or less), allowing the detection of cTnT and cTnI in all healthy individuals. Along with this, there are opportunities to use cTnT and cTnI both to assess the risk of developing CVD in healthy people, and to identify and monitor many early pathological conditions that pose a risk to the cardiovascular system and the life of patients. These pathological conditions include hypertension (HTN), which is the direct cause leading to coronary heart disease, acute myocardial infarction, stroke, and other CVD. A number of recent studies reported the possibility of using highly sensitive cTnT and cTnI in the management of HTN patients. In this article, we consider in detail the diagnostic and prognostic value of cardiac troponins in HTN, we also discuss the main possible mechanisms underlying the increase in cTnT and cTnI in human body fluids.

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The authors declare that there are no conflicts of interest present.