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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2022-28-3-243-252</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-2174</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Жесткость сосудистой стенки и центральное аортальное давление у пациентов с артериальной гипертензией и аневризмой брюшной аорты</article-title><trans-title-group xml:lang="en"><trans-title>Arterial stiffness and central aortic blood pressure in patients with hypertension and abdominal aortic aneurysm</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1489-3618</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуревич Александра Павловна — младший научный сотрудник научно-исследовательской лаборатории патогенеза и терапии артериальной гипертензии научно-исследовательского отдела артериальной гипертензии</p><p>ул. Аккуратова, д.2, Санкт-Петербург, 197341</p><p> </p></bio><bio xml:lang="en"><p>Aleksandra P. Gurevich, MD, Junior Researcher, Department for Arterial Hypertension</p><p>2 Akkuratov street, St Petersburg, 197341</p></bio><email xlink:type="simple">gurevich_ap@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3176-0606</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelyanov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Емельянов Игорь Витальевич — кандидат медицинских наук, старший научный сотрудник научно-исследовательской лаборатории патогенеза и терапии артериальной гипертензии научно-исследовательского отдела артериальной гипертензии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Igor V. Emelyanov, MD, PhD, Senior Researcher, Department for Arterial Hypertension, Department for Arterial Hypertension</p><p>St Petersburg</p></bio><email xlink:type="simple">emelyanov_iv@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5601-0668</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бояринова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Boyarinova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бояринова Мария Анатольевна — научный сотрудник научно-исследовательской лаборатории популяционной генетики научно-исследовательского отдела генетических рисков и персонифицированной профилактики Научного центра мирового уровня «Центр персонифицированной медицины»</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Maria A. Boyarinova, MD, Researcher, Research Laboratory of Population Genetics, Research Department of Genetic Risks and Personalized Prevention, a World-Class Research Centre for Personalized Medicine</p><p>St Petersburg</p><p> </p></bio><email xlink:type="simple">boyarinova_ma@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0838-5390</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Могучая</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Moguchaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Могучая Екатерина Викторовна — младший научный сотрудник научно-исследовательской лаборатории эпидемиологии неинфекционных заболеваний Института сердца и сосудов</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Ekaterina V. Moguchaya, MD, Junior Researcher, Scientific Research Laboratory of Epidemiology of Noncommunicable Diseases</p><p>St Petersburg</p><p> </p></bio><email xlink:type="simple">moguchaya_ev@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5530-9772</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ротарь</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Rotar</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ротарь Оксана Петровна — доктор медицинских наук, главный научный сотрудник научно-исследовательской лаборатории эпидемиологии неинфекционных заболеваний Института сердца и сосудов</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Oxana P. Rotar, MD, PhD, DSc, Chief Researcher, Scientific Research Laboratory of Epidemiology of Noncommunicable Diseases</p><p>St Petersburg</p></bio><email xlink:type="simple">rotar_op@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2111-0765</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудаев</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudaev</surname><given-names>Y. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кудаев Юрий Анатольевич — врач-кардиолог отделения сердечно-сосудистой хирургии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Yuriy A. Kudaev, MD, Cardiologist, Vascular Surgery Department</p><p>St Petersburg</p></bio><email xlink:type="simple">kudaev51@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1214-0150</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернявский</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyavskiy</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернявский Михаил Александрович — доктор медицинских наук, главный научный сотрудник, руководитель научноисследовательского отдела сосудистой и интервенционной хирургии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Mikhail A. Chernyavskiy, MD, PhD, DSc, Head, Department for Vascular and Interventional Surgery</p><p>St Petersburg</p><p> </p></bio><email xlink:type="simple">chernyavskiy_ma@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8169-7812</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Конради Александра Олеговна—доктор медицинских наук, профессор, член-корреспондент РАН, заведующая кафедрой организации, управления и экономики здравоохранения Института медицинского образования, заместитель генерального директора по научной работе</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Aleksandra O. Konradi, MD, PhD, DSc, Professor, Corresponding Member of the RAS, Head, Department of Organization, Management and Economics of Healthcare, Institute of Medical Education, Deputy General Director on Research</p><p>St Petersburg</p><p> </p></bio><email xlink:type="simple">konradi_ao@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2022</year></pub-date><volume>28</volume><issue>3</issue><fpage>243</fpage><lpage>252</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гуревич А.П., Емельянов И.В., Бояринова М.А., Могучая Е.В., Ротарь О.П., Кудаев Ю.А., Чернявский М.А., Конради А.О., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Гуревич А.П., Емельянов И.В., Бояринова М.А., Могучая Е.В., Ротарь О.П., Кудаев Ю.А., Чернявский М.А., Конради А.О.</copyright-holder><copyright-holder xml:lang="en">Gurevich A.P., Emelyanov I.V., Boyarinova M.A., Moguchaya E.V., Rotar O.P., Kudaev Y.A., Chernyavskiy M.A., Konradi A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/2174">https://htn.almazovcentre.ru/jour/article/view/2174</self-uri><abstract><p>Цель исследования — оценить показатели сосудистой жесткости, периферического и центрального артериального давления (АД) и их взаимосвязь с показателями, характеризующими структуру пораженной аорты, у пациентов с артериальной гипертензией (АГ) в сочетании с аневризмой брюшной аорты (АБА).</p><sec><title>Материалы и методы</title><p>Материалы и методы. Обследованы 75 пациентов с АГ в сочетании с АБА. Контрольную группу составили 75 пациентов с АГ без АБА. Группы были сопоставимы по возрасту и полу. Всем пациентам измеряли периферическое АД (OMRON M3 EXPERT, Япония) и проводили неинвазивное определение центрального АД, индекса аугментации (ИА), давления аугментации (ДА), каротидно-феморальной скорости распространения пульсовой волны (кфСРПВ) (SphygmoCor, AtCorMedical, Австралия).</p></sec><sec><title>Результаты</title><p>Результаты. При оценке кфСРПВ у всех пациентов с АБА и группы контроля различий не найдено (10,3 (2,2) против 9,7 (2,1) м/с; р = 0,102). Возраст, периферическое систолическое АД (САД) и диаметр АБА являются значимыми независимыми предикторами кфСРПВ у пациентов с АБА (β = 0,271, р = 0,029; β = 0,272, р = 0,030 и β = –0,361, р = 0,004 соответственно). В подгруппе пациентов с диаметром АБА более 60 мм кфСРПВ была ниже по сравнению с группой контроля (8,8 (1,5) против 9,7 (2,1) м/с; р &lt; 0,05), а у пациентов с диаметром АБА менее 60 мм, напротив, выявлено повышение кфСРПВ по сравнению с контрольной группой (11,8 (1,7) против 9,7 (2,1) м/с; р &lt; 0,001). Периферическое САД и периферическое пульсовое давление (ПД) между группами АБА и контроля существенно не отличались (138,6 (16,4) против 138,1 (13,6) мм рт. ст.; р = 0,831 и 58,6 (11,8) против 59,6 (10,2) мм рт. ст.; р = 0,569 соответственно). Анализ центральной пульсовой волны показал повышение ИА и ДА у пациентов с АБА по сравнению с контролем (27,6 (8,2) против 21,3 (7,9)%; p &lt; 0,001 и 17,3 (6,8) против 13,9 (5,4) мм рт. ст.; p = 0,001 соответственно). Центральное САД и центральное ПД было выше в группе пациентов с АБА по сравнению с контрольной группой (130,0 (16,4) против 124,9 (13,9) мм рт. ст.; р = 0,046 и 49,5 (11,7) против 45,7 (9,9) мм рт. ст.; р = 0,031 соответственно).</p></sec><sec><title>Выводы</title><p>Выводы. При АБА кфСРПВ была тем ниже, чем больше был диаметр аорты в зоне аневризмы. У пациентов с АГ, сочетающейся с АБА, кфСРПВ не может являться адекватной мерой оценки сосудистой жесткости вследствие возможного искажающего влияния аневризмы на биомеханические свойства аорты. Для определения сосудистой жесткости у таких пациентов необходимы методы локальной оценки, основанные на изучении эластических характеристик стенки аорты в различных ее сегментах, такие как компьютерно-томографическая ангиография и магнитно-резонансная томография. Увеличение параметров, характеризующих отраженную пульсовую волну, в частности ДА и его индекса, при АГ в сочетании с АБА может являться дополнительным гемодинамическим фактором повышения давления в аорте и более выраженного поражения органов-мишеней.</p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To assess the arterial stiffness, peripheral and central aortic blood pressure (PBP and CBP), and to determinate their relationships with indicators of structural changes of the affected aorta in patients with hypertension (HTN) and abdominal aortic aneurysms (AAA).</p></sec><sec><title>Design and methods</title><p>Design and methods. We examined 75 patients with HTN and AAA and 75 controls with HTN without AAA. Groups matched by age and gender. A PBP was measured by OMRON (Japan). Noninvasive measurements of CBP, augmentation index (AIx), augmentation pressure (AP), carotid-femoral pulse wave velocity (cfPWV) were assessed by SphygmoCor (AtCorMedical, Australia).</p></sec><sec><title>Results</title><p>Results. There was no difference in cfPWV between patients with AAA and control group (10,3 (2,2) vs 9,7 (2,1) m/s; р = 0,102). Age, systolic PBP, and aortic diameter were independent predictors of cfPVV in patients with AAA (β = 0,271, р = 0,029; β = 0,272, р = 0,030 и β = –0,361, р = 0,004, respectively). Patients with large aortic diameter of AAA (&gt; 60 mm) had decreased cfPWV compared with control group (8,8 (1,5) vs 9,7 (2,1) m/s; р &lt; 0,05), patients with AAA diameter less than 60 mm, on the contrary, had increased cfPVV compared with the controls (11,8 (1,7) vs 9,7 (2,1) m/s; р &lt; 0,001). Patients with AAA and patients of control group did not differ in systolic and pulse PBP (138,6 (16,4) vs 138,1 (13,6) mm Hg; р = 0,831 and 58,6 (11,8) vs 59,6 (10,2) mm Hg; р = 0,569, respectively). AIx and AP were higher in patients with AAA versus patients without AAA (27,6 (8,2) vs 21,3 (7,9)%; р &lt; 0,001 and 17,3 (6,8) vs 13,9 (5,4) mm Hg; р = 0,001, respectively). Systolic and pulse CBP were higher in patients with AAA than in patients of control group (130,0 (16,4) vs 124,9 (13,9) mm Hg; р = 0,046 and 49,5 (11,7) vs 45,7 (9,9) mm Hg; р = 0,031, respectively).</p></sec><sec><title>Conclusions</title><p>Conclusions. In patients with AAA cfPWV decreased with the expansion of the maximum aortic diameter. CfPWV is not suitable for accurate arterial stiffness assessment in patients with HTN and AAA due to the apparent confounding effect of aneurysm on the biomechanical properties of the aorta. Local assessment of the elastic properties of the aorta such as computed tomography angiography and magnetic resonance imaging is required for arterial stiffness evaluation in patients with AAA. Parameters of the reflected pulse wave such as AP and AIx are increased in patients with AAA. This might contribute to the increase in central aortic BP and target organ damage in patients with HTN combined with AAA.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аневризма брюшной аорты</kwd><kwd>артериальная жесткость</kwd><kwd>каротидно-феморальная скорость распространения пульсовой волны</kwd><kwd>центральное аортальное давление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>abdominal aortic aneurysms</kwd><kwd>arterial stiffness</kwd><kwd>carotid-femoral pulse wave velocity</kwd><kwd>central aortic blood pressure</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Министерства науки и высшего образования Российской Федерации (Соглашение № 075–15– 2020–901 от 13.11.2020)</funding-statement><funding-statement xml:lang="en">This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075–15–2020– 901 dated 13.11.2020)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kuivaniemi H, Ryer EJ, Elmore JR, Tromp G. Understanding the pathogenesis of abdominal aortic aneurysms. Expert Rev Cardiovasc Ther. 2015;13(9):975–987. doi: 10.1586/14779072.2015.1074861</mixed-citation><mixed-citation xml:lang="en">Kuivaniemi H, Ryer EJ, Elmore JR, Tromp G. Understanding the pathogenesis of abdominal aortic aneurysms. Expert Rev Cardiovasc Ther. 2015;13(9):975–987. doi: 10.1586/14779072.2015.1074861</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Takagi H, Goto SN, Matsui M, Manabe H, Umemoto T. A further meta-analysis of population-based screening for abdominal aortic aneurysm. J Vasc Surg. 2010;52(4):1103–1108. doi:10.1016/j.jvs.2010.02.283</mixed-citation><mixed-citation xml:lang="en">Takagi H, Goto SN, Matsui M, Manabe H, Umemoto T. A further meta-analysis of population-based screening for abdominal aortic aneurysm. J Vasc Surg. 2010;52(4):1103–1108. doi:10.1016/j.jvs.2010.02.283</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Benson RA, Poole R, Murray S, Moxey P, Loftus IM. Screening results from a large United Kingdom abdominal aortic aneurysm screening center in the context of optimizing United Kingdom National Abdominal Aortic Aneurysm Screening Programme protocols. J Vasc Surg. 2016;63(2):301–304. doi:10.1016/j.jvs.2015.08.091</mixed-citation><mixed-citation xml:lang="en">Benson RA, Poole R, Murray S, Moxey P, Loftus IM. Screening results from a large United Kingdom abdominal aortic aneurysm screening center in the context of optimizing United Kingdom National Abdominal Aortic Aneurysm Screening Programme protocols. J Vasc Surg. 2016;63(2):301–304. doi:10.1016/j.jvs.2015.08.091</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hager J, Lanne T, Carlsson P, Lundgren F. No benefit of screening for abdominal aortic aneurysm among 70-instead of 65-year-old men. Int Angiol. 2014;33(5):474–479.</mixed-citation><mixed-citation xml:lang="en">Hager J, Lanne T, Carlsson P, Lundgren F. No benefit of screening for abdominal aortic aneurysm among 70-instead of 65-year-old men. Int Angiol. 2014;33(5):474–479.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wanhainen A, Hultgren R, Linné A, Holst J, Gottsäter A, Langenskiöld M et al.; Swedish Aneurysm Screening Study Group (SASS). Outcome of the Swedish nationwide abdominal aortic aneurysm Screening program. Circulation. 2016;134(16):1141– 1148. doi:10.1161/CIRCULATIONAHA.116.022305</mixed-citation><mixed-citation xml:lang="en">Wanhainen A, Hultgren R, Linné A, Holst J, Gottsäter A, Langenskiöld M et al.; Swedish Aneurysm Screening Study Group (SASS). Outcome of the Swedish nationwide abdominal aortic aneurysm Screening program. Circulation. 2016;134(16):1141– 1148. doi:10.1161/CIRCULATIONAHA.116.022305</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Затевахин И.И., Матюшкин А.В. Осложненные аневризмы абдоминальной аорты. М.: Изд-во Литтерра, 2010. С. 39–58.</mixed-citation><mixed-citation xml:lang="en">Zatevakhin II, Matyushkin AV. Complicated abdominal aortic aneurysms. Moscow: Publishing House Litterra, 2010. P. 39–58. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bath MF, Gokani VJ, Sidloff DA, Jones LR, Choke E, Sayers RD et al. Systematic review of cardiovascular disease and cardiovascular death in patients with a small abdominal aortic aneurysm. Br J Surg. 2015;102(8):866–872. doi:10.1002/bjs.9837</mixed-citation><mixed-citation xml:lang="en">Bath MF, Gokani VJ, Sidloff DA, Jones LR, Choke E, Sayers RD et al. Systematic review of cardiovascular disease and cardiovascular death in patients with a small abdominal aortic aneurysm. Br J Surg. 2015;102(8):866–872. doi:10.1002/bjs.9837</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chambers D, Epstein D, Walker S, Fayter D, Paton F, Wright K et al. Endovascular stents for abdominal aortic aneurysms: a systematic review and economic model. Health Technol Assess. 2009;13(48):1–189,215–318, iii. doi:10.3310/hta13480</mixed-citation><mixed-citation xml:lang="en">Chambers D, Epstein D, Walker S, Fayter D, Paton F, Wright K et al. Endovascular stents for abdominal aortic aneurysms: a systematic review and economic model. Health Technol Assess. 2009;13(48):1–189,215–318, iii. doi:10.3310/hta13480</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Brown LC, Thompson SG, Greenhalgh RM, Powell JT; Endovascular Aneurysm Repair trial participants. Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1. Br J Surg. 2011;98(7):935–942. doi:10.1002/bjs.7485</mixed-citation><mixed-citation xml:lang="en">Brown LC, Thompson SG, Greenhalgh RM, Powell JT; Endovascular Aneurysm Repair trial participants. Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1. Br J Surg. 2011;98(7):935–942. doi:10.1002/bjs.7485</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Karthikesalingam A, Bahia SS, Patterson BO, Peach G, Vidal-Diez A, Ray KK et al. The shortfall in long-term survival of patients with repaired thoracic or abdominal aortic aneurysms: retrospective case-control analysis of hospital episode statistics. Eur J Vasc Endovasc Surg. 2013;46(5):533–541. doi:10.1016/j.ejvs.2013.09.008</mixed-citation><mixed-citation xml:lang="en">Karthikesalingam A, Bahia SS, Patterson BO, Peach G, Vidal-Diez A, Ray KK et al. The shortfall in long-term survival of patients with repaired thoracic or abdominal aortic aneurysms: retrospective case-control analysis of hospital episode statistics. Eur J Vasc Endovasc Surg. 2013;46(5):533–541. doi:10.1016/j.ejvs.2013.09.008</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kuivaniemi H, Ryer EJ, Elmore JR, Tromp G. Understanding the pathogenesis of abdominal aortic aneurysms. Expert Rev Cardiovasc Ther. 2015;13(9):975–987. doi:10.1586/14779072.2015.1074861</mixed-citation><mixed-citation xml:lang="en">Kuivaniemi H, Ryer EJ, Elmore JR, Tromp G. Understanding the pathogenesis of abdominal aortic aneurysms. Expert Rev Cardiovasc Ther. 2015;13(9):975–987. doi:10.1586/14779072.2 015.1074861</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Golledge J, Muller J, Daugherty A, Norman P. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006;26(12):2605–2613. doi:10.1161/01.ATV.0000245819.32762.cb</mixed-citation><mixed-citation xml:lang="en">Golledge J, Muller J, Daugherty A, Norman P. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006;26(12):2605–2613. doi:10.1161/01.ATV.0000245819.32762.cb</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant metaanalysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63(7):636–646. doi:10.1016/j.jacc.2013.09.063</mixed-citation><mixed-citation xml:lang="en">Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant metaanalysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63(7):636–646. doi:10.1016/j.jacc.2013.09.063</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lee CW, Sung SH, Chen CK, Chen IM, Cheng HM, Yu WC et al. Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm. J Hypertens. 2013;31(9):1853–1860. doi:10.1097/HJH.0b013e328362360a</mixed-citation><mixed-citation xml:lang="en">Lee CW, Sung SH, Chen CK, Chen IM, Cheng HM, Yu WC et al. Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm. J Hypertens. 2013;31(9):1853–1860. doi:10.1097/HJH.0b013e328362360a</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Durmus I, Kazaz Z, Altun G, Cansu A. Augmentation index and aortic pulse wave velocity in patients with abdominal aortic aneurysms. Int J Clin Exp Med. 2014;7(2):421–425.</mixed-citation><mixed-citation xml:lang="en">Durmus I, Kazaz Z, Altun G, Cansu A. Augmentation index and aortic pulse wave velocity in patients with abdominal aortic aneurysms. Int J Clin Exp Med. 2014;7(2):421–425.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey MA, Davies JM, Griffin KJ, Bridge KI, Johnson AB, Sohrabi S et al. Carotid-femoral pulse wave velocity is negatively correlated with aortic diameter. Hypertens Res. 2014;37(10):926– 932. doi:10.1038/hr.2014.101</mixed-citation><mixed-citation xml:lang="en">Bailey MA, Davies JM, Griffin KJ, Bridge KI, Johnson AB, Sohrabi S et al. Carotid-femoral pulse wave velocity is negatively correlated with aortic diameter. Hypertens Res. 2014;37(10):926– 932. doi:10.1038/hr.2014.101</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Åström Malm I, De Basso R, Blomstrand P, Bjarnegård N. Increased arterial stiffness in males with abdominal aortic aneurysm. Clin Physiol Funct Imaging. 2021;41(1):68–75. doi:10.1111/cpf.12667</mixed-citation><mixed-citation xml:lang="en">Åström Malm I, De Basso R, Blomstrand P, Bjarnegård N. Increased arterial stiffness in males with abdominal aortic aneurysm. Clin Physiol Funct Imaging. 2021;41(1):68–75. doi:10.1111/cpf.12667</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D et al.; European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588–2605. doi:10.1093/eurheartj/ehl254</mixed-citation><mixed-citation xml:lang="en">Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D et al.; European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588–2605. doi:10.1093/eurheartj/ehl254</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Koullias G, Modak RK, Korkolis D, Barash P, Elefteriades JA. Mechanical and elastic properties of the normal and aneurysmal ascending aorta by intraoparative epiaortic echocardiography. J Am Coll Cardiol. 2003;41(6SupplII):513a. doi:10.1016/S0735-1097(03)82775-4</mixed-citation><mixed-citation xml:lang="en">Koullias G, Modak RK, Korkolis D, Barash P, Elefteriades JA. Mechanical and elastic properties of the normal and aneurysmal ascending aorta by intraoparative epiaortic echocardiography. J Am Coll Cardiol. 2003;41(6SupplII):513a. doi:10.1016/S0735-1097(03)82775-4</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mikael LR, Paiva AMG, Gomes MM, Sousa ALL, Jardim PCBV, Vitorino PVO et al. Vascular aging and arterial stiffness. Arq Bras Cardiol. 2017;109(3):253–258. doi:10.5935/abc.20170091</mixed-citation><mixed-citation xml:lang="en">Mikael LR, Paiva AMG, Gomes MM, Sousa ALL, Jardim PCBV, Vitorino PVO et al. Vascular aging and arterial stiffness. Arq Bras Cardiol. 2017;109(3):253–258. doi:10.5935/abc.20170091</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Vlachopoulos C, Aznaouridis K, O’Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J. 2010;31(15):1865–1871. doi:10.1093/eurheartj/ehq024</mixed-citation><mixed-citation xml:lang="en">Vlachopoulos C, Aznaouridis K, O’Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J. 2010;31(15):1865–1871. doi:10.1093/eurheartj/ehq024</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vande Geest JP, Sacks MS, Vorp DA. The effects of aneurysm on the biaxial mechanical behavior of human abdominal aorta. J Biomech. 2006;39(7):1324–1334. doi:10.1016/j.jbiomech.2005.03.003</mixed-citation><mixed-citation xml:lang="en">Vande Geest JP, Sacks MS, Vorp DA. The effects of aneurysm on the biaxial mechanical behavior of human abdominal aorta. J Biomech. 2006;39(7):1324–1334. doi:10.1016/j.jbiomech.2005.03.003</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Raaz U, Zöllner AM, Schellinger IN, Toh R, Nakagami F, Brandt M et al. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development. Circulation. 2015;131(20):1783–1795. doi:10.1161/CIRCULATIONAHA.114.012377</mixed-citation><mixed-citation xml:lang="en">Raaz U, Zöllner AM, Schellinger IN, Toh R, Nakagami F, Brandt M et al. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development. Circulation. 2015;131(20):1783–1795. doi:10.1161/CIRCULATIONAHA.114.012377</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И.Е., Жернакова Ю.В. от имени экспертов. Клинические рекомендации. Диагностика и лечение артериальной гипертонии. Системные гипертензии. 2019;16(1):6–31. doi:10.26442/2075082X.2019.1.190179</mixed-citation><mixed-citation xml:lang="en">Chazova IE, Zhernakova YuV on behalf of the experts. Clinical guidelines. Diagnosis and treatment of arterial hypertension. Syst Hypertens. 2019;16(1):6–31. doi:10.26442/2075082X.2019.1.190179. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gallagher D, Adji A, O’Rourke MF. Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform. Am J Hypertens. 2004;17(11Pt1):1059–1067. doi:10.1016/j.amjhyper.2004.05.027</mixed-citation><mixed-citation xml:lang="en">Gallagher D, Adji A, O’Rourke MF. Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform. Am J Hypertens. 2004;17(11Pt1):1059–1067. doi:10.1016/j.amjhyper.2004.05.027</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson IB, Mohammad NH, Tyrrell S, Hall IR, Webb DJ, Paul VE et al. Heart rate dependency of pulse pressure amplification and arterial stiffness. Am J Hypertens. 2002;15(1Pt1):24–30. doi:10.1016/s0895-7061(01)02252-x</mixed-citation><mixed-citation xml:lang="en">Wilkinson IB, Mohammad NH, Tyrrell S, Hall IR, Webb DJ, Paul VE et al. Heart rate dependency of pulse pressure amplification and arterial stiffness. Am J Hypertens. 2002;15(1Pt1):24–30. doi:10.1016/s0895-7061(01)02252-x</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T et al. Artery Society; European Society of Hypertension Working Group on Vascular Structure and Function; European Network for Noninvasive Investigation of Large Arteries. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30(3):445–448. doi:10.1097/HJH.0b013e32834fa8b0</mixed-citation><mixed-citation xml:lang="en">Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T et al. Artery Society; European Society of Hypertension Working Group on Vascular Structure and Function; European Network for Noninvasive Investigation of Large Arteries. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30(3):445–448. doi:10.1097/HJH.0b013e32834fa8b0</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Иванова С.В., Школьник Е.Л., Котовская Ю.В., Милягин В.А., Олейников В.Э. и др. Согласованное мнение российских экспертов по оценке артериальной жесткости в клинической практике. Кардиоваскулярная терапия и профилактика. 2016;15(2):4–19. doi:10.15829/1728-8800-2016-2-4-19</mixed-citation><mixed-citation xml:lang="en">Vasyuk YA, Ivanova SV, Shkolnik EL, Kotovskaya YV, Milyagin VA, Oleynikov VE et al. Consensus of Russian experts on the evaluation of arterial stiffness in clinical practice. Cardiovasc Ther Prev. 2016;15(2):4–19. doi:10.15829/1728-8800-2016-2-4-19. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kim HL, Kim SH. Pulse wave velocity in atherosclerosis. Front Cardiovasc Med. 2019;6:41. doi:10.3389/fcvm.2019.00041</mixed-citation><mixed-citation xml:lang="en">Kim HL, Kim SH. Pulse wave velocity in atherosclerosis. Front Cardiovasc Med. 2019;6:41. doi:10.3389/fcvm.2019.00041</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Millasseau SC, Stewart AD, Patel SJ, Redwood SR, Chowienczyk PJ. Evaluation of carotid-femoral pulse wave velocity: influence of timing algorithm and heart rate. Hypertension. 2005;45(2):222–226. doi:10.1161/01.HYP.0000154229.97341.d2</mixed-citation><mixed-citation xml:lang="en">Millasseau SC, Stewart AD, Patel SJ, Redwood SR, Chowienczyk PJ. Evaluation of carotid-femoral pulse wave velocity: influence of timing algorithm and heart rate. Hypertension. 2005;45(2):222–226. doi:10.1161/01.HYP.0000154229.97341.d2</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nichols WW, O’Rouke MF, Vlackopoulos C. McDonald’s blood flow in arteries: theoretical, experimental and clinical principles. London: Hodder Arnold. 2011. P. 369–387.</mixed-citation><mixed-citation xml:lang="en">Nichols WW, O’Rouke MF, Vlackopoulos C. McDonald’s blood flow in arteries: theoretical, experimental and clinical principles. London: Hodder Arnold. 2011. P. 369–387.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
