arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2022-28-1-17-26arthyper-2196Research ArticleОБЗОРREVIEWПрименение фиксированных комбинаций лекарственных средств как способ комплексной оптимизации антигипертензивной терапии: фокус на сочетание амлодипина, индапамида, периндоприлаFixed drug combinations as a way of complex antihypertensive therapy optimization: focus on the combination of amlodipine, indapamide, perindoprilhttps://orcid.org/0000-0002-1302-9326ПоветкинС. В.PovetkinS. V.

Поветкин Сергей Владимирович — доктор медицинских наук, профессор, заведующий кафедрой клинической фармакологии

Курск

Sergey V. Povetkin, MD, PhD, DSc, Professor, Head, Department of Clinical Pharmacology

Kursk

povetkinsv@kursksmu.nethttps://orcid.org/0000-0002-0197-9826КорниловА. А.KornilovA. A.

Корнилов Арсен Александрович—кандидат медицинских наук, доцент кафедры клинической фармакологии

ул. К. Маркса, д.3, г. Курск, Россия, 305041

Arsen A. Kornilov, MD, PhD, Associate Professor, Department of Clinical Pharmacology

3 K. Marksa str., Kursk, 305041

drarsmen@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Курский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKursk State Medical UniversityRussian Federation2022180320222811726Copyright © Поветкин С.В., Корнилов А.А., 20222022Поветкин С.В., Корнилов А.А.Povetkin S.V., Kornilov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2196

Настоящая статья представляет собой анализ современных данных об артериальной гипертензии (АГ) как ведущем факторе риска преждевременной смерти. Приводятся сведения, указывающие на недостижение целевых уровней артериального давления у значимого числа лиц в человеческой популяции. В статье описаны возможности фармакологической коррекции АГ основными классами антигипертензивных лекарственных средств в свете действующих клинических рекомендаций. Представлены преимущества применения фиксированных комбинаций (ФК) антигипертензивных препаратов как приоритетного подхода в лечении большинства больных гипертонической болезнью. Рассматриваются возможности комплексной оптимизации лечения пациентов с АГ за счет применения тройной ФК антигипертензивных средств, содержащей амлодипин, индапамид и периндоприл.

This article is an analysis of current data on arterial hypertension (HTN) as a leading risk factor for premature death. We discuss the reasons of the failure to achieve target levels of blood pressure, and the available approaches to HTN pharmacological treatment by the main classes of antihypertensive drugs in accordance with current clinical guidelines. We show the advantages of fixed combinations (FC) of antihypertensive drugs and the ways to optimize antihypertensive treatment by administration of a triple FC, containing amlodipine, indapamide and perindopril.

 

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The authors declare that there are no conflicts of interest present.