arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2023-29-1-6-13arthyper-2215Research ArticleОбзоры и лекцииReviewСолечувствительная артериальная гипертензия: современные патогенетические механизмы и перспективыSalt-sensitive hypertension: modern pathogenetic mechanisms and prospectshttps://orcid.org/0000-0002-6233-7202АнтроповаО. Н.AntropovaO. N.

Антропова Оксана Николаевна — доктор медицинских наук, профессор кафедры факультетской терапии и профессиональных болезней

Oxana N. Antropova, MD, PhD, DSc, Professor, Department of Therapy and Occupational Diseases

antropovaon@mail.ruhttps://orcid.org/0000-0001-5283-4996ОбразцоваЛ. А.ObraztsovaL. A.

Образцова Лолита Андреевна — студентка

Lolita A. Obraztsova, Student

mob1977@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Алтайский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияAltay State Medical UniversityRussian Federation202302122022291613Copyright © Антропова О.Н., Образцова Л.А., 20232023Антропова О.Н., Образцова Л.А.Antropova O.N., Obraztsova L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2215

В статье представлены результаты современных исследований, демонстрирующих новые патогенетические звенья и потенциальные мишени терапии солечувствительной артериальной гипертензии (АГ). Выделение солечувствительного фенотипа и нечувствительных к соли лиц может рассматриваться в качестве одного из подходов персонализированной медицины. В обзоре отдельное внимание уделено состоянию кишечной микробиоты как этиологического фактора солечувствительной АГ, который, наряду с дисбалансом нейрогуморальных систем и последующим дисрегуляторным гемодинамическим ответом на солевую нагрузку, играет ведущую роль в развитии солечувствительности. Рассмотрены преимущества и ограничения использования методов количественной оценки потребляемого натрия, указаны пути их оптимизации, что необходимо для более точного определения оптимального порога потребляемой соли.

The article presents the recent data on the pathogenic links and potential targets for the treatment of salt-sensitive hypertension (HTN). Distinguishing salt-sensitive and salt-resistant phenotypes is one approach to personalized medicine. In the review, special attention is paid to the intestinal microbiota as an etiological factor in salt-sensitive HTN, which, along with the imbalance of neurohumoral systems and the subsequent dysregulatory hemodynamic response to salt load, plays a leading role in the development of salt sensitivity. The advantages and limitations of methods for quantitative assessment of sodium intake are discussed, ways of their optimization are indicated, which is necessary for a more accurate determination of the optimal threshold for salt intake.

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The authors declare that there are no conflicts of interest present.